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219
(2003) Effect of mutation on enzyme motion
in dihydrofolate reductase. J Am Chem Soc
125:3745–3750
100. Hammes-Schiffer S, Benkovic SJ (2006)
Relating protein motion to catalysis. Annu
Rev Biochem 75:519–541
101. Wong KF, Selzer T, Benkovic SJ, HammesSchiffer S (2005) Impact of distal mutations
on the network of coupled motions correlated
to hydride transfer in dihydrofolate reductase.
Proc Natl Acad Sci U S A 102
(19):6807–6812
102. Mauldin RV, Carroll MJ, Lee AL (2009)
Dynamic dysfunction in dihydrofolate reductase results from antifolate drug binding:
modulation of dynamics within a structural
state. Structure 17(3):386–394
Distal Regions Regulate Dihydrofolate Reductase-Ligand Interactions
219