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febs.12586
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(ed) Computer applications in pharmaceutical
research and development. Wiley, New York,
pp 277–300
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vintage
yet
attractive?
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pro.660
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doi.org/10.1007/BF00276625
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applications. PLoS Comput Biol. https://doi.
org/10.1371/journal.pcbi.1004966
34. Monod J (1977) Chance and necessity: essay
on the natural philosophy of modern biology.
Penguin Group, London
35. Fenton AW (2008) Allostery: an illustrated
definition for the ‘second secret of life’. Trends
Biochem Sci 33:420–425. https://doi.org/10.
1016/j.tibs.2008.05.009
6
Alessandro Finazzi Agro ` and Giampiero Mei
acs.chemrev.6b00283
23. Monod J, Wyman J, Changeux JP (1965) On
the nature of allosteric transitions: a plausible
model. J Mol Biol 12:88–118. https://doi.
org/10.1016/S0022-2836(65)80285-6
24. Perutz MF (1970) Stereochemistry of cooperative effects in haemoglobin. Nature
228:726–734.
https://doi.org/10.1038/
228726a0
25. Buc H (2013) The design of an enzyme: a
chronology on the controversy. J Mol Biol
425:1407–1409. https://doi.org/10.1016/j.
jmb.2013.03.015
26. Crick FHC, Wyman J (2013) A footnote on
allostery. J Mol Biol 425:1500–1508. https://
doi.org/10.1016/j.jmb.2013.03.012
27. Koshland DE, Ne ´methy G, Filmer D (1966)
Comparison of experimental binding data and
theoretical models in proteins containing subunits
* . Biochemistry 5:365–385. https://doi.
org/10.1021/bi00865a047
28. Brunori M (2014) Variations on the theme:
allosteric control in hemoglobin. FEBS J
281:633–643.
https://doi.org/10.1111/
febs.12586
29. Fermi G, Perutz MF, Shaanan B, Fourme R
(1984) The crystal structure of human
deoxyhaemoglobin at 1.74 A ˚ resolution. J
Mol Biol 175:159–174. https://doi.org/10.
1016/0022-2836(84)90472-8
30. Edwards D, Hubbard R (2006) Computer and
protein
crystallography. In: Ekins
S
(ed) Computer applications in pharmaceutical
research and development. Wiley, New York,
pp 277–300
31. Brunori M (2011) Allostery turns 50: is the
vintage
yet
attractive?
Protein
Sci
20:1097–1099.
https://doi.org/10.1002/
pro.660
32. Cooper A, Dryden DTF (1984) Allostery without conformational change—a plausible
model. Eur Biophys J 11:103–109. https://
doi.org/10.1007/BF00276625
33. Liu J, Nussinov R (2016) Allostery: an overview of its history, concepts, methods, and
applications. PLoS Comput Biol. https://doi.
org/10.1371/journal.pcbi.1004966
34. Monod J (1977) Chance and necessity: essay
on the natural philosophy of modern biology.
Penguin Group, London
35. Fenton AW (2008) Allostery: an illustrated
definition for the ‘second secret of life’. Trends
Biochem Sci 33:420–425. https://doi.org/10.
1016/j.tibs.2008.05.009
6
Alessandro Finazzi Agro ` and Giampiero Mei