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conformational free energy changes in human
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dynamics and structure networks. Proteins 78
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29. Sistla RK, Brinda KV, Vishveshwara S (2005)
Identification of domains and domain interface
residues in multidomain proteins from graph
spectral method. Proteins 59(3):616–626
30. Kannan N et al (2001) Stabilizing interactions
in the dimer interface of alpha-subunit in
Escherichia coli RNA polymerase: a graph spectral and point mutation study. Protein Sci 10
(1):46–54
31. Brinda KV, Surolia A, Vishveshwara S (2005)
Insights into the quaternary association of proteins through structure graphs: a case study of
lectins. Biochem J 391(Pt 1):1–15
32. Reichmann D et al (2005) The modular architecture of protein-protein binding interfaces.
Proc Natl Acad Sci U S A 102(1):57–62
33. Trzaskowski B et al (2012) Action of molecular
switches in GPCRs—theoretical and experimental studies. Curr Med Chem 19
(8):1090–1109
34. Wettschureck N, Offermanns S (2005) Mammalian G proteins and their cell type specific
functions. Physiol Rev 85(4):1159–1204
35. Hazell GG et al (2012) G protein-coupled
receptors in the hypothalamic paraventricular
and supraoptic nuclei—serpentine gateways to
neuroendocrine homeostasis. Front Neuroendocrinol 33(1):45–66
36. Sharma N, Akhade AS, Qadri A (2013) Sphingosine-1-phosphate suppresses TLR-induced
CXCL8 secretion from human T cells. J Leukoc Biol 93(4):521–528
37. Overington JP, Al-Lazikani B, Hopkins AL
(2006) How many drug targets are there? Nat
Rev Drug Discov 5(12):993–996
38. Rasmussen SG et al (2011) Crystal structure of
the beta2 adrenergic receptor-Gs protein complex. Nature 477(7366):549–555
39. Wacker D et al (2010) Conserved binding
mode of human beta2 adrenergic receptor
inverse agonists and antagonist revealed by
X-ray crystallography. J Am Chem Soc 132
(33):11443–11445
40. Dixon RA et al (1986) Cloning of the gene and
cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature 321
(6065):75–79
41. Rasmussen SG et al (2007) Crystal structure of
the human beta2 adrenergic G-protein-coupled receptor. Nature 450(7168):383–387
42. Ballesteros JA, Weinstein H (1995) Integrated
methods for the construction of threedimensional models and computational probing of structure-function relations in G
protein-coupled receptors. In: Stuart CS
(ed) Methods in neurosciences. Academic,
New York, pp 366–428
43. Wallace AC, Laskowski RA, Thornton JM
(1995) LIGPLOT: a program to generate
schematic diagrams of protein-ligand interactions. Protein Eng 8(2):127–134
44. Needleman SB, Wunsch CD (1970) A general
method applicable to the search for similarities
in the amino acid sequence of two proteins. J
Mol Biol 48(3):443–453
112
Vasundhara Gadiyaram et al.
investigation of dynamically equilibrated structures of methionyl tRNA synthetase complexes. Biochemistry 47(44):11398–11407
28. Bhattacharyya M et al (2010) Allostery and
conformational free energy changes in human
tryptophanyl-tRNA synthetase from essential
dynamics and structure networks. Proteins 78
(3):506–517
29. Sistla RK, Brinda KV, Vishveshwara S (2005)
Identification of domains and domain interface
residues in multidomain proteins from graph
spectral method. Proteins 59(3):616–626
30. Kannan N et al (2001) Stabilizing interactions
in the dimer interface of alpha-subunit in
Escherichia coli RNA polymerase: a graph spectral and point mutation study. Protein Sci 10
(1):46–54
31. Brinda KV, Surolia A, Vishveshwara S (2005)
Insights into the quaternary association of proteins through structure graphs: a case study of
lectins. Biochem J 391(Pt 1):1–15
32. Reichmann D et al (2005) The modular architecture of protein-protein binding interfaces.
Proc Natl Acad Sci U S A 102(1):57–62
33. Trzaskowski B et al (2012) Action of molecular
switches in GPCRs—theoretical and experimental studies. Curr Med Chem 19
(8):1090–1109
34. Wettschureck N, Offermanns S (2005) Mammalian G proteins and their cell type specific
functions. Physiol Rev 85(4):1159–1204
35. Hazell GG et al (2012) G protein-coupled
receptors in the hypothalamic paraventricular
and supraoptic nuclei—serpentine gateways to
neuroendocrine homeostasis. Front Neuroendocrinol 33(1):45–66
36. Sharma N, Akhade AS, Qadri A (2013) Sphingosine-1-phosphate suppresses TLR-induced
CXCL8 secretion from human T cells. J Leukoc Biol 93(4):521–528
37. Overington JP, Al-Lazikani B, Hopkins AL
(2006) How many drug targets are there? Nat
Rev Drug Discov 5(12):993–996
38. Rasmussen SG et al (2011) Crystal structure of
the beta2 adrenergic receptor-Gs protein complex. Nature 477(7366):549–555
39. Wacker D et al (2010) Conserved binding
mode of human beta2 adrenergic receptor
inverse agonists and antagonist revealed by
X-ray crystallography. J Am Chem Soc 132
(33):11443–11445
40. Dixon RA et al (1986) Cloning of the gene and
cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature 321
(6065):75–79
41. Rasmussen SG et al (2007) Crystal structure of
the human beta2 adrenergic G-protein-coupled receptor. Nature 450(7168):383–387
42. Ballesteros JA, Weinstein H (1995) Integrated
methods for the construction of threedimensional models and computational probing of structure-function relations in G
protein-coupled receptors. In: Stuart CS
(ed) Methods in neurosciences. Academic,
New York, pp 366–428
43. Wallace AC, Laskowski RA, Thornton JM
(1995) LIGPLOT: a program to generate
schematic diagrams of protein-ligand interactions. Protein Eng 8(2):127–134
44. Needleman SB, Wunsch CD (1970) A general
method applicable to the search for similarities
in the amino acid sequence of two proteins. J
Mol Biol 48(3):443–453
112
Vasundhara Gadiyaram et al.