13
© Springer Nature Switzerland AG 2021
K. Dhusia et al. (eds.), Fungal Siderophores, Fungal Biology,
https://doi.org/10.1007/978-3-030-53077-8_2
Chapter 2
Inhibition of Siderophores in Blocking
Fungal Infection
Sonam Bhatia and Shaminder Singh
Contents
2.1 Introduction
13
2.2 Nature of Siderophores and Their Production
16
2.3 Screening of Compounds as Inhibitors of Siderophore Biosynthesis
18
2.3.1 Screening Through Biomonitor Organism
19
2.3.2 Screening of Compounds by Using Structural Similarity Approach
19
2.4 Blocking Siderophore as an Alternative Approach Toward Antifungal Therapy
20
2.4.1 Enzymatic Inhibitors Blocking the Production of Siderophore
20
2.4.2 Statins
22
2.4.3 Peptide-Based Inhibitors
23
2.4.4 Trojan Horse Approach
24
2.5 Conclusion
28
References
28
2.1 Introduction
A perilous increase in the number of microbial infections has led to develop throngs
of antibiotics for increasing the quality and expectancy of life. However, the gains
are just transient as the pathogens resist the antibiotic attack and generate the resistant forms called “persisters” which become drug tolerant. These pathogens are
found to utilize a number of ways to evade antibiotic attack and thus acquire MDR
(multidrug resistance) forms which are resistant to multiple antimicrobials event in
combined therapeutic regimes (Sunenshine et al. 2007; Beck-Sagué et al. 1992).
Thus, the chance of developing resistance increases among pathogens that can
withstand antibiotic stroke and thereby spread of the infection. The resistance can
be acquired either by plasmid/chromosome encoded or can be efflux pump mediS. Bhatia (*)
Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences
(SIHAS), FHS, SHUATS, Allahabad, Uttar Pradesh, India
e-mail: sonam.bhatia@shiats.edu.in
S. Singh
Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India
© Springer Nature Switzerland AG 2021
K. Dhusia et al. (eds.), Fungal Siderophores, Fungal Biology,
https://doi.org/10.1007/978-3-030-53077-8_2
Chapter 2
Inhibition of Siderophores in Blocking
Fungal Infection
Sonam Bhatia and Shaminder Singh
Contents
2.1 Introduction
13
2.2 Nature of Siderophores and Their Production
16
2.3 Screening of Compounds as Inhibitors of Siderophore Biosynthesis
18
2.3.1 Screening Through Biomonitor Organism
19
2.3.2 Screening of Compounds by Using Structural Similarity Approach
19
2.4 Blocking Siderophore as an Alternative Approach Toward Antifungal Therapy
20
2.4.1 Enzymatic Inhibitors Blocking the Production of Siderophore
20
2.4.2 Statins
22
2.4.3 Peptide-Based Inhibitors
23
2.4.4 Trojan Horse Approach
24
2.5 Conclusion
28
References
28
2.1 Introduction
A perilous increase in the number of microbial infections has led to develop throngs
of antibiotics for increasing the quality and expectancy of life. However, the gains
are just transient as the pathogens resist the antibiotic attack and generate the resistant forms called “persisters” which become drug tolerant. These pathogens are
found to utilize a number of ways to evade antibiotic attack and thus acquire MDR
(multidrug resistance) forms which are resistant to multiple antimicrobials event in
combined therapeutic regimes (Sunenshine et al. 2007; Beck-Sagué et al. 1992).
Thus, the chance of developing resistance increases among pathogens that can
withstand antibiotic stroke and thereby spread of the infection. The resistance can
be acquired either by plasmid/chromosome encoded or can be efflux pump mediS. Bhatia (*)
Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences
(SIHAS), FHS, SHUATS, Allahabad, Uttar Pradesh, India
e-mail: sonam.bhatia@shiats.edu.in
S. Singh
Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India