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© Springer Nature Switzerland AG 2021
K. Dhusia et al. (eds.), Fungal Siderophores, Fungal Biology,
https://doi.org/10.1007/978-3-030-53077-8_11
Chapter 11
Siderophores in Antifungal Drug
Discovery: A Computational Approach
Anusuya Shanmugam, Vanathi Chithiravel, Arthi Gunasekar,
and Anbazhagan Venkattappan
Contents
11.1 Introduction
174
11.1.1 Siderophores
175
11.2 Iron Acquisition Mechanism
175
11.2.1 Reductive Iron Acquisition
176
11.2.2 Siderophore Biosynthesis
176
11.2.3 Utilization of Siderophores by Non-producers
177
11.2.4 Host Molecule-Specific Iron Acquisition
178
11.2.5 Acidification and Mobilization
179
11.3 Siderophore-Mediated Iron Transport
179
11.3.1 Shuttle Mechanism
179
11.3.2 Taxicab Mechanism
179
11.3.3 Hydrolytic Mechanism
179
11.3.4 Reductive Mechanism
180
11.4 Siderophore-Mediated Iron Storage
180
11.5 Drug Discovery Strategies
180
11.5.1 Siderophore–Drug Conjugates
181
11.5.2 Siderophore Mimics
181
11.5.3 Siderophore Biosynthesis Inhibitors
182
11.5.4 Siderophore Transport Inhibitors
182
11.5.5 Computational Approaches
182
11.6 Conclusion
182
References
183
Authors Anusuya Shanmugam and Vanathi Chithiravel have contributed equally to this chapter.
A. Shanmugam (*) · V. Chithiravel · A. Gunasekar
Vinayaka Mission’s Kirupananda Variyar Engineering College, Vinayaka Mission’s Research
Foundation (Deemed to be University), Salem, Tamil Nadu, India
A. Venkattappan
Vinayaka Mission’s Kirupananda Variyar Arts & Science College, Vinayaka Mission’s
Research Foundation (Deemed to be University), Salem, Tamil Nadu, India