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Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, ... , Cruz-Morales P
(2015) Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11:625
Mohimani H, Liu WT, Kersten RD, Moore BS, Dorrestein PC, Pevzner PA (2014) NRPquest:
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Prod 77:1902–1909
Mohimani H, Gurevich A, Mikheenko A, Garg N, Nothias LF, Ninomiya A et al (2017)
Dereplication of peptidic natural products through database search of mass spectra. Nat Chem
Biol 13:30
Molinski TF (2010) Microscale methodology for structure elucidation of natural products. Curr
Opin Biotechnol 21:819–826
Mootz HD, Schwarzer D, Marahiel MA (2002) Ways of assembling complex natural products on
modular nonribosomal peptide synthetases. Chembiochem 3:490–504
Munawar A, Marshall JW, Cox RJ, Bailey AM, Lazarus CM (2013) Isolation and characterisation
of a ferrirhodin synthetase gene from the sugarcane pathogen Fusarium sacchari. Chembiochem
14:388–394
Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X et al (2013) MS/MS networking
guided analysis of molecule and gene cluster families. Proc Natl Acad Sci 110:E2611–E2620
Nielsen JC, Nielsen J (2017) Development of fungal cell factories for the production of secondary
metabolites: linking genomics and metabolism. Synth Syst Biotechnol 2:5–12
Nielsen MT, Nielsen JB, Anyaogu DC, Holm DK, Nielsen KF, Larsen TO, Mortensen UH (2013)
Heterologous reconstitution of the intact geodin gene cluster in Aspergillus nidulans through a
simple and versatile PCR based approach. PLoS One 8:e72871
Nielsen JC, Grijseels S, Prigent S, Ji B, Dainat J, Nielsen KF et al (2017) Global analysis of biosynthetic gene clusters reveals vast potential of secondary metabolite production in Penicillium
species. Nat Microbiol 2:17044
Posey JE, Gherardini FC (2000) Lack of a role for iron in the Lyme disease pathogen. Science
288:1651–1653
Price ND, Papin JA, Schilling CH, Palsson BO (2003) Genome-scale microbial in silico models:
the constraints-based approach. Trends Biotechnol 21:162–169
Prieto C, García-Estrada C, Lorenzana D, Martín JF (2011) NRPSsp: non-ribosomal peptide synthase substrate predictor. Bioinformatics 28:426–427
Quatrini R, Valdés J, Jedlicki E, Holmes DS (2007) The use of bioinformatics and genome biology
to advance our understanding of bioleaching microorganisms. In: Donati ER, Sand W (eds)
Microbial processing of metal sulfides. Springer, Dordrecht, pp 221–239
Ren H, Wang B, Zhao H (2017) Breaking the silence: new strategies for discovering novel natural
products. Curr Opin Biotechnol 48:21–27
Renshaw JC, Robson GD, TrinciAP WMG, Livens FR, Collison D, Taylor RJ (2002) Fungal siderophores: structures, functions and applications. Mycol Res 106:1123–1142
Ribeiro LF, Chelius CL, Harris SD, Marten MR (2017) Insights regarding fungal phosphoproteomic analysis. Fungal Genet Biol 104:38–44
Rondon MR, Ballering KS, Thomas MG (2004) Identification and analysis of a siderophore biosynthetic gene cluster from Agrobacterium tumefaciens C58. Microbiology 150:3857–3866
Röttig M, Medema MH, Blin K, Weber T, Rausch C, Kohlbacher O (2011) NRPSpredictor2—a web
server for predicting NRPS adenylation domain specificity. Nucleic Acids Res 39:W362–W367
Rutledge PJ, Challis GL (2015) Discovery of microbial natural products by activation of silent
biosynthetic gene clusters. Nat Rev Microbiol 13:509
Schaible UE, Kaufmann SH (2004) Iron and microbial infection. Nat Rev Microbiol 2:946–953
Schueffler A, Anke T (2014) Fungal natural products in research and development. Nat Prod Rep
31:1425–1448
Schwecke T, Göttling K, Durek P, Dueñas I, Käufer NF, Zock-Emmenthal S et al (2006)
Nonribosomal peptide synthesis in Schizosaccharomyces pombe and the architectures of
ferrichrome- type siderophore synthetases in fungi. Chembiochem 7:612–622
D. Subramanian et al.
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, ... , Cruz-Morales P
(2015) Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11:625
Mohimani H, Liu WT, Kersten RD, Moore BS, Dorrestein PC, Pevzner PA (2014) NRPquest:
coupling mass spectrometry and genome mining for nonribosomal peptide discovery. J Nat
Prod 77:1902–1909
Mohimani H, Gurevich A, Mikheenko A, Garg N, Nothias LF, Ninomiya A et al (2017)
Dereplication of peptidic natural products through database search of mass spectra. Nat Chem
Biol 13:30
Molinski TF (2010) Microscale methodology for structure elucidation of natural products. Curr
Opin Biotechnol 21:819–826
Mootz HD, Schwarzer D, Marahiel MA (2002) Ways of assembling complex natural products on
modular nonribosomal peptide synthetases. Chembiochem 3:490–504
Munawar A, Marshall JW, Cox RJ, Bailey AM, Lazarus CM (2013) Isolation and characterisation
of a ferrirhodin synthetase gene from the sugarcane pathogen Fusarium sacchari. Chembiochem
14:388–394
Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X et al (2013) MS/MS networking
guided analysis of molecule and gene cluster families. Proc Natl Acad Sci 110:E2611–E2620
Nielsen JC, Nielsen J (2017) Development of fungal cell factories for the production of secondary
metabolites: linking genomics and metabolism. Synth Syst Biotechnol 2:5–12
Nielsen MT, Nielsen JB, Anyaogu DC, Holm DK, Nielsen KF, Larsen TO, Mortensen UH (2013)
Heterologous reconstitution of the intact geodin gene cluster in Aspergillus nidulans through a
simple and versatile PCR based approach. PLoS One 8:e72871
Nielsen JC, Grijseels S, Prigent S, Ji B, Dainat J, Nielsen KF et al (2017) Global analysis of biosynthetic gene clusters reveals vast potential of secondary metabolite production in Penicillium
species. Nat Microbiol 2:17044
Posey JE, Gherardini FC (2000) Lack of a role for iron in the Lyme disease pathogen. Science
288:1651–1653
Price ND, Papin JA, Schilling CH, Palsson BO (2003) Genome-scale microbial in silico models:
the constraints-based approach. Trends Biotechnol 21:162–169
Prieto C, García-Estrada C, Lorenzana D, Martín JF (2011) NRPSsp: non-ribosomal peptide synthase substrate predictor. Bioinformatics 28:426–427
Quatrini R, Valdés J, Jedlicki E, Holmes DS (2007) The use of bioinformatics and genome biology
to advance our understanding of bioleaching microorganisms. In: Donati ER, Sand W (eds)
Microbial processing of metal sulfides. Springer, Dordrecht, pp 221–239
Ren H, Wang B, Zhao H (2017) Breaking the silence: new strategies for discovering novel natural
products. Curr Opin Biotechnol 48:21–27
Renshaw JC, Robson GD, TrinciAP WMG, Livens FR, Collison D, Taylor RJ (2002) Fungal siderophores: structures, functions and applications. Mycol Res 106:1123–1142
Ribeiro LF, Chelius CL, Harris SD, Marten MR (2017) Insights regarding fungal phosphoproteomic analysis. Fungal Genet Biol 104:38–44
Rondon MR, Ballering KS, Thomas MG (2004) Identification and analysis of a siderophore biosynthetic gene cluster from Agrobacterium tumefaciens C58. Microbiology 150:3857–3866
Röttig M, Medema MH, Blin K, Weber T, Rausch C, Kohlbacher O (2011) NRPSpredictor2—a web
server for predicting NRPS adenylation domain specificity. Nucleic Acids Res 39:W362–W367
Rutledge PJ, Challis GL (2015) Discovery of microbial natural products by activation of silent
biosynthetic gene clusters. Nat Rev Microbiol 13:509
Schaible UE, Kaufmann SH (2004) Iron and microbial infection. Nat Rev Microbiol 2:946–953
Schueffler A, Anke T (2014) Fungal natural products in research and development. Nat Prod Rep
31:1425–1448
Schwecke T, Göttling K, Durek P, Dueñas I, Käufer NF, Zock-Emmenthal S et al (2006)
Nonribosomal peptide synthesis in Schizosaccharomyces pombe and the architectures of
ferrichrome- type siderophore synthetases in fungi. Chembiochem 7:612–622
D. Subramanian et al.