139
Nudelman R, Ardon O, Hadar Y et al (1998) Modular fluorescent-labeled siderophore analogues.
J Med Chem 41:1671–1678. https://doi.org/10.1021/jm970581b
Origa R, Bina P, Agus A et al (2005) Combined therapy with deferiprone and desferrioxamine in
thalassemia major. Haematologica 90(10):1309–1314.
Ouchetto H, Dias M, Mornet R et al (2005) A new route to trihydroxamate-containing artificial
siderophores and synthesis of a new fluorescent probe. Bioorganic Med Chem 13:1799–1803.
https://doi.org/10.1016/j.bmc.2004.11.053
Palanché T, Marmolle F, Abdallah MA et al (1999) Fluorescent siderophore-based chemosensors:
Iron(III) quantitative determinations. J Biol Inorg Chem 4:188–198. https://doi.org/10.1007/
s007750050304
Petrik M, Haas H, Dobrozemsky G et al (2010) 68Ga-siderophores for PET imaging of invasive
pulmonary aspergillosis: proof of principle. J Nucl Med. 51:639–645 https://doi.org/10.2967/
jnumed.109.072462
Petrik M, Haas H, Schrettl M et al (2012) In vitro and in vivo evaluation of selected
68Ga-siderophores for infection imaging. Nucl Med Biol 39:361–369. https://doi.org/10.1016/j.
nucmedbio.2011.09.012
Petrik M, Haas H, Laverman P et al (2014) 68Ga-triacetylfusarinine C and 68Ga-ferrioxamine e
for aspergillus infection imaging: uptake specificity in various microorganisms. Mol Imaging
Biol 16:102–108. https://doi.org/10.1007/s11307-013-0654-7
Petrik M, Zhai C, Haas H, Decristoforo C (2017) Siderophores for molecular imaging applications. Clin Transl Imaging 5(1):15–27
Philpott CC, Protchenko O (2008) Response to iron deprivation in Saccharomyces cerevisiae.
Eukaryot Cell 7(1):20–27
Pidacks C, Whitehill AR, Pruess LM et al (1953) Coprogen, the isolation of a new growth factor
required by Pilobolus species. J Am Chem Soc 75:6064–6065
Renshaw JC, Robson GD, Trinci APJ et al (2002) Fungal siderophores: structures, functions and
applications. Mycol Res 106:1123–1142
Scarrow RC, Raymond KN (1985) Ferric ion sequencing agents. 14. 1-Hydroxy-2(1H)-pyridinone
complex: properties and structure of a novel Fe-Fe dimer. J Am Chem Soc 107:6540–6546
Schalk IJ (2018) A Trojan-horse strategy including a bacterial suicide action for the efficient use
of a specific gram-positive antibiotic on gram-negative bacteria. J Med Chem 61:3842–3844
Smith SN, Eaton KA, Sumner CA et al (2016) Siderophore vaccine conjugates protect against
uropathogenic Escherichia coli urinary tract infection. Proc Natl Acad Sci 113:13468–13473.
https://doi.org/10.1073/pnas.1606324113
Szebesczyk A, Olshvang E, Shanzer A et al (2016) Harnessing the power of fungal siderophores
for the imaging and treatment of human diseases. Coord Chem Rev 327:84–109
Thieken A, Winkelmann G (1992) Rhizoferrin: a complexone type siderophore of the mocorales and entomophthorales (Zygomycetes). FEMS Microbiol Lett 94:37–41. https://doi.
org/10.1016/0378-1097(92)90579-D
Varma A, Giang PH, Das A, et al (2007) Fungal siderophores: structure, functions and regulation. In: Microbial Siderophores. A. Varma, S.B. Chincholkar (Eds.) Springer-Verlag, Berlin,
Heidelberg. p.1–42.
Walter K-S (1963) Uber die Konstitution von Ferrirubin, Ferrirhodin und Ferrichrom A. Helv
Chim Acta 46:1920–1929
Walter K-S, Deér A (1963) Zur Konstitution von Ferrichrysin und Ferricrocin. Helv Chim Acta
46:1907–1920
Wencewicz TA, Miller MJ (2013) Biscatecholate-monohydroxamate mixed ligand siderophorecarbacephalosporin conjugates are selective sideromycin antibiotics that target Acinetobacter
baumannii. J Med Chem 56:4044–4052. https://doi.org/10.1021/jm400265k
Wencewicz TA, Long TE, Möllmann U, Miller MJ (2013) Trihydroxamate siderophorefluoroquinolone conjugates are selective sideromycin antibiotics that target staphylococcus
aureus. Bioconjug Chem 24:473–486. https://doi.org/10.1021/bc300610f
8 Chemistry and Biomedical Applications of Fungal Siderophores
Nudelman R, Ardon O, Hadar Y et al (1998) Modular fluorescent-labeled siderophore analogues.
J Med Chem 41:1671–1678. https://doi.org/10.1021/jm970581b
Origa R, Bina P, Agus A et al (2005) Combined therapy with deferiprone and desferrioxamine in
thalassemia major. Haematologica 90(10):1309–1314.
Ouchetto H, Dias M, Mornet R et al (2005) A new route to trihydroxamate-containing artificial
siderophores and synthesis of a new fluorescent probe. Bioorganic Med Chem 13:1799–1803.
https://doi.org/10.1016/j.bmc.2004.11.053
Palanché T, Marmolle F, Abdallah MA et al (1999) Fluorescent siderophore-based chemosensors:
Iron(III) quantitative determinations. J Biol Inorg Chem 4:188–198. https://doi.org/10.1007/
s007750050304
Petrik M, Haas H, Dobrozemsky G et al (2010) 68Ga-siderophores for PET imaging of invasive
pulmonary aspergillosis: proof of principle. J Nucl Med. 51:639–645 https://doi.org/10.2967/
jnumed.109.072462
Petrik M, Haas H, Schrettl M et al (2012) In vitro and in vivo evaluation of selected
68Ga-siderophores for infection imaging. Nucl Med Biol 39:361–369. https://doi.org/10.1016/j.
nucmedbio.2011.09.012
Petrik M, Haas H, Laverman P et al (2014) 68Ga-triacetylfusarinine C and 68Ga-ferrioxamine e
for aspergillus infection imaging: uptake specificity in various microorganisms. Mol Imaging
Biol 16:102–108. https://doi.org/10.1007/s11307-013-0654-7
Petrik M, Zhai C, Haas H, Decristoforo C (2017) Siderophores for molecular imaging applications. Clin Transl Imaging 5(1):15–27
Philpott CC, Protchenko O (2008) Response to iron deprivation in Saccharomyces cerevisiae.
Eukaryot Cell 7(1):20–27
Pidacks C, Whitehill AR, Pruess LM et al (1953) Coprogen, the isolation of a new growth factor
required by Pilobolus species. J Am Chem Soc 75:6064–6065
Renshaw JC, Robson GD, Trinci APJ et al (2002) Fungal siderophores: structures, functions and
applications. Mycol Res 106:1123–1142
Scarrow RC, Raymond KN (1985) Ferric ion sequencing agents. 14. 1-Hydroxy-2(1H)-pyridinone
complex: properties and structure of a novel Fe-Fe dimer. J Am Chem Soc 107:6540–6546
Schalk IJ (2018) A Trojan-horse strategy including a bacterial suicide action for the efficient use
of a specific gram-positive antibiotic on gram-negative bacteria. J Med Chem 61:3842–3844
Smith SN, Eaton KA, Sumner CA et al (2016) Siderophore vaccine conjugates protect against
uropathogenic Escherichia coli urinary tract infection. Proc Natl Acad Sci 113:13468–13473.
https://doi.org/10.1073/pnas.1606324113
Szebesczyk A, Olshvang E, Shanzer A et al (2016) Harnessing the power of fungal siderophores
for the imaging and treatment of human diseases. Coord Chem Rev 327:84–109
Thieken A, Winkelmann G (1992) Rhizoferrin: a complexone type siderophore of the mocorales and entomophthorales (Zygomycetes). FEMS Microbiol Lett 94:37–41. https://doi.
org/10.1016/0378-1097(92)90579-D
Varma A, Giang PH, Das A, et al (2007) Fungal siderophores: structure, functions and regulation. In: Microbial Siderophores. A. Varma, S.B. Chincholkar (Eds.) Springer-Verlag, Berlin,
Heidelberg. p.1–42.
Walter K-S (1963) Uber die Konstitution von Ferrirubin, Ferrirhodin und Ferrichrom A. Helv
Chim Acta 46:1920–1929
Walter K-S, Deér A (1963) Zur Konstitution von Ferrichrysin und Ferricrocin. Helv Chim Acta
46:1907–1920
Wencewicz TA, Miller MJ (2013) Biscatecholate-monohydroxamate mixed ligand siderophorecarbacephalosporin conjugates are selective sideromycin antibiotics that target Acinetobacter
baumannii. J Med Chem 56:4044–4052. https://doi.org/10.1021/jm400265k
Wencewicz TA, Long TE, Möllmann U, Miller MJ (2013) Trihydroxamate siderophorefluoroquinolone conjugates are selective sideromycin antibiotics that target staphylococcus
aureus. Bioconjug Chem 24:473–486. https://doi.org/10.1021/bc300610f
8 Chemistry and Biomedical Applications of Fungal Siderophores