99
© Springer Nature Switzerland AG 2021
K. Dhusia et al. (eds.), Fungal Siderophores, Fungal Biology,
https://doi.org/10.1007/978-3-030-53077-8_7
Chapter 7
Contrasting Role of Fungal Siderophore
in Metal Ion Complex Formation
Snigdha Bhardwaj, Shaminder Singh, and Sonam Bhatia
Contents
7.1
Introduction
100
7.2
Siderophore-Mediated Iron Transport
100
7.3
Fungal Iron Regulation
102
7.3.1 Iron (Fe
3+ ) Uptake Through Siderophore
102
7.3.2 Reductive Iron Assimilation (RIA)
102
7.3.3 Heme Uptake
102
7.3.4 Low-Affinity Iron Uptake
103
7.4 Types of Siderophore
103
7.4.1 Hydroxamate Siderophores
104
7.4.2 Carboxylate Siderophores
104
7.4.3 Catecholate Siderophore
105
7.4.4 Mixed Ligand Siderophores
105
7.5
Mechanism of Binding of Iron in Cell
105
7.6
Binding Sites in Siderophores
107
7.7
Metal Ion Complex Formation with Siderophore
108
7.8
Biological Functions of Siderophore
111
7.8.1 An Iron-Scavenging Compound
111
7.8.2 Virulence Factor
111
7.8.3 Intracellular Iron Storage
112
7.9 Applications of Siderophore
112
7.10 Conclusion
114
References
114
S. Bhardwaj · S. Bhatia (*)
Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences
(SIHAS), FHS, SHUATS, Naini, Prayagraj, Uttar Pradesh, India
e-mail: sonam.bhatia@shiats.edu.in
S. Singh
Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India