161. Du Y, Li B, Wei H, Wang Y, Wang E (2008) Multifunctional label-free electrochemical
biosensor based on an integrated aptamer. Anal Chem 80(13):5110–5117. https://doi.org/10.
1021/ac800303c
162. Yurkovetsky ZR, Linkov FY, Malehorn DE, Lokshin AE (2006) Multiple biomarker panels
for early detection of ovarian cancer. Future Oncol 2(6):733–741. https://doi.org/10.2217/
14796694.2.6.733
163. Komarova E, Reber K, Aldissi M, Bogomolova A (2010) New multispecific array as a tool for
electrochemical impedance spectroscopy-based biosensing. Biosens Bioelectron 25
(6):1389–1394. https://doi.org/10.1016/j.bios.2009.10.034
164. Lee J, Cho S, Lee J, Ryu H, Park J, Lim S, Oh B, Lee C, Huang W, Busnaina A, Lee H (2013)
Wafer-scale nanowell array patterning based electrochemical impedimetric immunosensor.
J Biotechnol 168(4):584–588. https://doi.org/10.1016/j.jbiotec.2013.08.029
165. Periyakaruppan A, Arumugam PU, Meyyappan M, Koehne JE (2011) Detection of ricin using
a carbon nanofiber based biosensor. Biosens Bioelectron 28(1):428–433. https://doi.org/10.
1016/j.bios.2011.07.061
166. Qureshi A, Gurbuz Y, Niazi JH (2010) Label-free detection of cardiac biomarker using
aptamer based capacitive biosensor. Procedia Eng 5:828–830. https://doi.org/10.1016/j.
proeng.2010.09.236
167. Lim T, Lee SY, Yang J, Hwang SY, Ahn Y (2016) Microfluidic biochips for simple
impedimetric detection of thrombin based on label-free DNA aptamers. Biochip J 11
(2):109–115. https://doi.org/10.1007/s13206-016-1203-7
168. Lum J, Wang R, Hargis B, Tung S, Bottje W, Lu H, Li Y (2015) An impedance aptasensor
with microfluidic chips for specific detection of H5N1 avian influenza virus. Sensors 15
(8):18565–18578. https://doi.org/10.3390/s150818565
169. Wang Y, Ye Z, Ping J, Jing S, Ying Y (2014) Development of an aptamer-based impedimetric
bioassay using microfluidic system and magnetic separation for protein detection. Biosens
Bioelectron 59:106–111. https://doi.org/10.1016/j.bios.2014.03.015
170. Zubtsov DA, Ivanov SM, Rubina AY, Dementieva EI, Chechetkin VR, Zasedatelev AS (2006)
Effect of mixing on reaction–diffusion kinetics for protein hydrogel-based microchips.
J Biotechnol 122(1):16–27. https://doi.org/10.1016/j.jbiotec.2005.08.010
171. Feng S, Chen C, Wang W, Que L (2018) An aptamer nanopore-enabled microsensor for
detection of theophylline. Biosens Bioelectron 105:36–41. https://doi.org/10.1016/j.bios.
2018.01.016
172. Liao W, Cui XT (2007) Reagentless aptamer based impedance biosensor for monitoring a
neuro-inflammatory cytokine PDGF. Biosens Bioelectron 23(2):218–224. https://doi.org/10.
1016/j.bios.2007.04.004
173. Keefe AD, Cload ST (2008) SELEX with modified nucleotides. Curr Opin Chem Biol 12
(4):448–456. https://doi.org/10.1016/j.cbpa.2008.06.028
174. The Eyetech Study Group (2003) Anti-vascular endothelial growth factor therapy for
subfoveal choroidal neovascularization secondary to age-related macular degeneration:
phase II study results. Ophthalmology 110(5):979–986. https://doi.org/10.1016/S0161-6420
(03)00085-X
175. González-Fernández E, de-los-Santos-Álvarez N, Lobo-Castañón MJ, Miranda-Ordieres AJ,
Tuñón-Blanco P (2011) Impedimetric aptasensor for tobramycin detection in human serum.
Biosens Bioelectron 26(5):2354–2360. https://doi.org/10.1016/j.bios.2010.10.011
176. Rowe AA, Miller EA, Plaxco KW (2010) Reagentless measurement of aminoglycoside
antibiotics in blood serum via an electrochemical, ribonucleic acid aptamer-based biosensor.
Anal Chem 82(17):7090–7095. https://doi.org/10.1021/ac101491d
Impedimetric Aptamer-Based Biosensors: Applications
91
biosensor based on an integrated aptamer. Anal Chem 80(13):5110–5117. https://doi.org/10.
1021/ac800303c
162. Yurkovetsky ZR, Linkov FY, Malehorn DE, Lokshin AE (2006) Multiple biomarker panels
for early detection of ovarian cancer. Future Oncol 2(6):733–741. https://doi.org/10.2217/
14796694.2.6.733
163. Komarova E, Reber K, Aldissi M, Bogomolova A (2010) New multispecific array as a tool for
electrochemical impedance spectroscopy-based biosensing. Biosens Bioelectron 25
(6):1389–1394. https://doi.org/10.1016/j.bios.2009.10.034
164. Lee J, Cho S, Lee J, Ryu H, Park J, Lim S, Oh B, Lee C, Huang W, Busnaina A, Lee H (2013)
Wafer-scale nanowell array patterning based electrochemical impedimetric immunosensor.
J Biotechnol 168(4):584–588. https://doi.org/10.1016/j.jbiotec.2013.08.029
165. Periyakaruppan A, Arumugam PU, Meyyappan M, Koehne JE (2011) Detection of ricin using
a carbon nanofiber based biosensor. Biosens Bioelectron 28(1):428–433. https://doi.org/10.
1016/j.bios.2011.07.061
166. Qureshi A, Gurbuz Y, Niazi JH (2010) Label-free detection of cardiac biomarker using
aptamer based capacitive biosensor. Procedia Eng 5:828–830. https://doi.org/10.1016/j.
proeng.2010.09.236
167. Lim T, Lee SY, Yang J, Hwang SY, Ahn Y (2016) Microfluidic biochips for simple
impedimetric detection of thrombin based on label-free DNA aptamers. Biochip J 11
(2):109–115. https://doi.org/10.1007/s13206-016-1203-7
168. Lum J, Wang R, Hargis B, Tung S, Bottje W, Lu H, Li Y (2015) An impedance aptasensor
with microfluidic chips for specific detection of H5N1 avian influenza virus. Sensors 15
(8):18565–18578. https://doi.org/10.3390/s150818565
169. Wang Y, Ye Z, Ping J, Jing S, Ying Y (2014) Development of an aptamer-based impedimetric
bioassay using microfluidic system and magnetic separation for protein detection. Biosens
Bioelectron 59:106–111. https://doi.org/10.1016/j.bios.2014.03.015
170. Zubtsov DA, Ivanov SM, Rubina AY, Dementieva EI, Chechetkin VR, Zasedatelev AS (2006)
Effect of mixing on reaction–diffusion kinetics for protein hydrogel-based microchips.
J Biotechnol 122(1):16–27. https://doi.org/10.1016/j.jbiotec.2005.08.010
171. Feng S, Chen C, Wang W, Que L (2018) An aptamer nanopore-enabled microsensor for
detection of theophylline. Biosens Bioelectron 105:36–41. https://doi.org/10.1016/j.bios.
2018.01.016
172. Liao W, Cui XT (2007) Reagentless aptamer based impedance biosensor for monitoring a
neuro-inflammatory cytokine PDGF. Biosens Bioelectron 23(2):218–224. https://doi.org/10.
1016/j.bios.2007.04.004
173. Keefe AD, Cload ST (2008) SELEX with modified nucleotides. Curr Opin Chem Biol 12
(4):448–456. https://doi.org/10.1016/j.cbpa.2008.06.028
174. The Eyetech Study Group (2003) Anti-vascular endothelial growth factor therapy for
subfoveal choroidal neovascularization secondary to age-related macular degeneration:
phase II study results. Ophthalmology 110(5):979–986. https://doi.org/10.1016/S0161-6420
(03)00085-X
175. González-Fernández E, de-los-Santos-Álvarez N, Lobo-Castañón MJ, Miranda-Ordieres AJ,
Tuñón-Blanco P (2011) Impedimetric aptasensor for tobramycin detection in human serum.
Biosens Bioelectron 26(5):2354–2360. https://doi.org/10.1016/j.bios.2010.10.011
176. Rowe AA, Miller EA, Plaxco KW (2010) Reagentless measurement of aminoglycoside
antibiotics in blood serum via an electrochemical, ribonucleic acid aptamer-based biosensor.
Anal Chem 82(17):7090–7095. https://doi.org/10.1021/ac101491d
Impedimetric Aptamer-Based Biosensors: Applications
91