Fig. 6
Different designs of aptamer-modified mesoporous silica nanoparticles. Drug release can be prevented by blocking of drug-containing pores with
complementary DNA and aptamer upon target binding (a), or with aptamer-modified gold nanoparticles, that bind on targets with lower binding strength next to
the drug-containing pores upon competitive displacement by the targets (b). By using electrostatic interactions for drug binding inside the pores, drug can be
released by pH shift (c) (according to [103–105])
180
A. Eilers et al.
Different designs of aptamer-modified mesoporous silica nanoparticles. Drug release can be prevented by blocking of drug-containing pores with
complementary DNA and aptamer upon target binding (a), or with aptamer-modified gold nanoparticles, that bind on targets with lower binding strength next to
the drug-containing pores upon competitive displacement by the targets (b). By using electrostatic interactions for drug binding inside the pores, drug can be
released by pH shift (c) (according to [103–105])
180
A. Eilers et al.