Table 4
Examples of aptamer-based targeted drug delivery systems
Nanomaterial
Aptamer
Target
Drug
Possible application
Reference
Au
sgc8
Protein tyrosine kinase
7 (PTK 7)
Doxorubicin
Leukemia treatment
[7]
Au
sgc8 and AS1411
PTK 7 and nucleolin
Daunorubicin
Leukemia treatment
[86]
Liposome
sgc8
Protein tyrosine kinase
7 (PTK 7)
FITC-dextran (model
drug)
Leukemia treatment
[91]
Liposome
AS1411
Nucleolin
siRNA (anti BRAF)
Treatment of malignant
melanoma
[92]
PEG-PCL
S15 and S6
A549 cells
Paclitaxel
Lung cancer treatment
[6]
PEG-PCL
AS1411
Nucleolin
Docetaxel
Brain glioma treatment
[95]
PLGA-b-PEG
A10
Prostate-specific membrane
antigen (PSMA)
Docetaxel
Prostate cancer treatment
[81]
PLGA-b-PEG
A10
Prostate-specific membrane
antigen (PSMA)
Cisplatin
Prostate cancer treatment
[82]
PLGA-b-PEG
A10
Prostate-specific membrane
antigen (PSMA)
Doxorubicin + docetaxel Prostate cancer treatment
[84]
PLGA-PEG
A10
Prostate-specific membrane
antigen (PSMA)
Cisplatin + docetaxel
Prostate cancer treatment
[97]
CA-PLGA-b-TPGS AS1411
Nucleolin
Docetaxel
Breast cancer treatment
[98]
PLA-PEG-COOH
A10
Prostate-specific membrane
antigen (PSMA)
Rhodamine-dextran
(model)
Prostate cancer treatment
[108]
PEG-PLA
FB4
bEND5 cells
Flurbiprofen
Alzheimer’s disease treatment
[80]
PLGA
AS1411
Nucleolin
Paclitaxel
Glial cancer treatment
[100]
PLGA
S2.2
MUC1
Paclitaxel
Breast cancer treatment
[101]
PEI-citrate
CD 30 aptamer
CD 30
siRNA
Anaplastic large-cell lymphoma (ALCL) treatment
[102]
Mesoporous silica
nanoparticle
AS1411
Nucleolin
Doxorubicin
Breast cancer treatment
[104]
(continued)
Aptamer-Modified Nanoparticles in Medical Applications
173