Fig. 1
Lateral
flow assay with aptamer-modified gold nanoparticles. (a) Competitive assay format, cOligo on test zone, control oligo on control zone (binds,
e.g., part of aptamer on spacer sequence, which doesn’t interact with target/is free to bind even when target binds). (b) Sandwich format, aptamer on test zone
which binds target, conjugated AuNPs bind target as well. AuNP sizes from CP/AP and NZ differ for better visualization
Aptamer-Modified Nanoparticles in Medical Applications
167
Lateral
flow assay with aptamer-modified gold nanoparticles. (a) Competitive assay format, cOligo on test zone, control oligo on control zone (binds,
e.g., part of aptamer on spacer sequence, which doesn’t interact with target/is free to bind even when target binds). (b) Sandwich format, aptamer on test zone
which binds target, conjugated AuNPs bind target as well. AuNP sizes from CP/AP and NZ differ for better visualization
Aptamer-Modified Nanoparticles in Medical Applications
167