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99. Boisgard R, Kuhnast B, Vonhoff S et al (2005) In vivo biodistribution and pharmacokinetics
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Med Mol Imaging 32:470–477
100. Dos Santos S, Rodrigues Corrêa C, Branco de Barros A et al (2015) Identification of
Staphylococcus aureus infection by aptamers directly radiolabeled with technetium-99m.
Nucl Med Biol 42:292–298
101. Kryza D, Debordeaux F, Azéma L et al (2016) Ex vivo and in vivo imaging and biodistribution
of aptamers targeting the human matrix metalloprotease-9 in melanomas. PLoS One 11:
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160
V. Calzada
83. Boros E, Gale E, Caravan P (2015) MR imaging probes: design and applications. Dalton Trans
44:4804–4818
84. Dulińska-Litewka J, Łazarczyk A, Hałubiec P et al (2019) Superparamagnetic iron oxide
nanoparticles-current and prospective medical applications. Materials 12:E617
85. Zhang Y, Zhang T, Liu M et al (2018) Aptamer-targeted magnetic resonance imaging contrast
agents and their applications. J Nanosci Nanotechnol 18:3759–3774
86. Wang A, Bagalkot V, Vasilliou C et al (2008) Superparamagnetic iron oxide nanoparticleaptamer bioconjugates for combined prostate cancer imaging and therapy. ChemMedChem
3:1311–1315
87. Yigit M, Mazumdar D, Lu Y (2008) MRI detection of thrombin with aptamer functionalized
superparamagnetic iron oxide nanoparticles. Bioconjug Chem 19:412–417
88. Li J, You J, Wu C et al (2018) T1-T2 molecular magnetic resonance imaging of renal
carcinoma cells based on nano-contrast agents. Int J Nanomedicine 13:4607–4625
89. Yan H, Gao X, Zhang Y et al (2018) Imaging tiny hepatic tumor xenografts via endoglintargeted paramagnetic/optical nanoprobe. ACS Appl Mater Interfaces 10:17047–17057
90. Schutt E, Klein D, Mattrey R et al (2003) Injectable microbubbles as contrast agents for
diagnostic ultrasound imaging: the key role of perfluorochemicals. Angew Chem Int Ed Engl
42:3218–3235
91. Nakatsuka M, Mattrey R, Esener S et al (2012) Aptamer-crosslinked microbubbles: smart
contrast agents for thrombin-activated ultrasound imaging. Adv Mater 24:6010–6016
92. Wang C, Huang Y, Yeh C (2011) Aptamer-conjugated nanobubbles for targeted ultrasound
molecular imaging. Langmuir 27:6971–6976
93. Gu F, Hu C, Xia Q et al (2018) Aptamer-conjugated multi-walled carbon nanotubes as a new
targeted ultrasound contrast agent for the diagnosis of prostate cancer. J Nanopart Res
20:303–323
94. Townsend D (2008) Dual-modality imaging: combining anatomy and function. J Nucl Med
49:938–955
95. Tavitian B, Ducongé F, Boisgard R et al (2009) In vivo imaging of oligonucleotidic aptamers.
Methods Mol Biol 535:241–259
96. Charlton J, Sennello J, Smith D (1997) In vivo imaging of inflammation using an aptamer
inhibitor of human neutrophil elastase. Chem Biol 4:809–816
97. Kim HJ, Park JY, Lee TS (2019) PET imaging of HER2 expression with an 18F-fluoride
labeled aptamer. PLoS One 14:e0211047
98. Gijs M, Becker G, Plenevaux A et al (2016) Biodistribution of novel 68Ga-radiolabelled
HER2 aptamers in mice. J Nucl Med Radiat Ther 7:300
99. Boisgard R, Kuhnast B, Vonhoff S et al (2005) In vivo biodistribution and pharmacokinetics
of 18F-labelled Spiegelmers: a new class of oligonucleotidic radiopharmaceuticals. Eur J Nucl
Med Mol Imaging 32:470–477
100. Dos Santos S, Rodrigues Corrêa C, Branco de Barros A et al (2015) Identification of
Staphylococcus aureus infection by aptamers directly radiolabeled with technetium-99m.
Nucl Med Biol 42:292–298
101. Kryza D, Debordeaux F, Azéma L et al (2016) Ex vivo and in vivo imaging and biodistribution
of aptamers targeting the human matrix metalloprotease-9 in melanomas. PLoS One 11:
e0149387
160
V. Calzada
