Contents
Part I Population Genetic Theory
1 Coalescent Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . .
3
John Wakeley
2 Linkage Disequilibrium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . 31
Montgomery Slatkin
3 Analysis of Population Structure .. . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . 47
Per Sjödin, Lucie Gattepaille, Pontus Skoglund, Carina Schlebusch,
and Mattias Jakobsson
4 Types of Natural Selection and Tests of Selection . . . .. . . . . . . . . . . . . . . . . . . . 69
David Enard
Part II Association Studies and Medical Genetics
5 Methods for Association Studies . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . 89
Rebecca E. Graff, Caroline G. Tai, Linda Kachuri, and John S. Witte
6 Identity by Descent in the Mapping of Genetic Traits . . . . . . . . . . . . . . . . . . . 123
Elizabeth A. Thompson
7 What Have We Learned from GWAS? . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . 159
Benjamin F. Voight
Part III Human Evolutionary Population Genetics
8 Inferring Human Demographic History from Genetic Data .. . . . . . . . . . . 187
Jeffrey D. Wall
9 Natural Selection, Genetic Variation, and Human Diversity .. . . . . . . . . . . 205
Leslie S. Emery and Joshua M. Akey
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