180
B. F. Voight
Iyengar SK, Elston RC (2007) The genetic basis of complex traits: rare variants or “common gene,
common disease”? Methods Mol Biol. 376:71–84
Johnson RC, Nelson GW, Troyer JL, Lautenberger JA, Kessing BD, Winkler CA, O’Brien SJ
(2010) Accounting for multiple comparisons in a genome-wide association study (GWAS).
BMC Genomics 11:724–724
Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC,
Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, Li M,
Derohannessian S, de Bakker PI, Bailey SD, Montpetit A, Edmondson AC, Taylor K, Gai X,
Wang SS, Fornage M, Shaikh T, Groop L, Boehnke M, Hall AS, Hattersley AT, Frackelton E,
Patterson N, Chiang CW, Kim CE, Fabsitz RR, Ouwehand W, Price AL, Munroe P, Caulfield
M, Drake T, Boerwinkle E, Reich D, Whitehead AS, Cappola TP, Samani NJ, Lusis AJ, Schadt
E, Wilson JG, Koenig W, McCarthy MI, Kathiresan S, Gabriel SB, Hakonarson H, Anand SS,
Reilly M, Engert JC, Nickerson DA, Rader DJ, Hirschhorn JN, Fitzgerald GA (2008) Concept,
design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale
genomic association studies. PLoS One 3(10):e3583
Kilpeläinen TO, Zillikens MC, Stanákova A, Finucane FM, Ried JS, Langenberg C, Zhang W,
Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U et al (2011) Genetic variation near IRS1
associates with reduced adiposity and an impaired metabolic profile. Nat Genet 43:753–760
Knowler WC, Williams RC, Pettitt DJ, Steinberg AG (1988) Gm3;5,13,14 and type 2 diabetes
mellitus: an association in American Indians with genetic admixture. Am J Hum Genet 43:520–
526
Kruglyak L (1999) Prospects for whole-genome linkage disequilibrium mapping of common
disease genes. Nat Genet 22:139–144
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson
AU, Vedantam S, Raychaudhuri S, Ferreira T et al (2010) Hundreds of variants clustered in
genomic loci and biological pathways affect human height. Nature 467:832–838
Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR (2010) MaCH: using sequence and genotype data
to estimate haplotypes and unobserved genotypes. Genet Epidemiol 34:816–834
Lohmueller KE (2014) The impact of population demography and selection on the genetic
architecture of complex traits. PLoS Genet 10(5):e1004379
Maher B (2008) Personal genomes: the case of the missing heritability. Nature 456:18–21
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos
EM, Cardon LR, Chakravarti A et al (2009) Finding the missing heritability of complex
diseases. Nature 461:747–753
Marchini J, Howie B (2010) Genotype imputation for genome-wide association studies. Nat Rev
Genet 11:499–511
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ,
Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni
S, Kumar A, Lagou V, Langenberg C, Luan J, Lindgren CM, Müller-Nurasyid M, Pechlivanis S,
Rayner NW, Scott LJ, Wiltshire S, Yengo L, Kinnunen L, Rossin EJ, Raychaudhuri S, Johnson
AD, Dimas AS, Loos RJ, Vedantam S, Chen H, Florez JC, Fox C, Liu CT, Rybin D, Couper DJ,
Kao WH, Li M, Cornelis MC, Kraft P, Sun Q, van Dam RM, Stringham HM, Chines PS, Fischer
K, Fontanillas P, Holmen OL, Hunt SE, Jackson AU, Kong A, Lawrence R, Meyer J, Perry JR,
Platou CG, Potter S, Rehnberg E, Robertson N, Sivapalaratnam S, Stanˇ cáková A, Stirrups K,
Thorleifsson G, Tikkanen E, Wood AR, Almgren P, Atalay M, Benediktsson R, Bonnycastle LL,
Burtt N, Carey J, Charpentier G, Crenshaw AT, Doney AS, Dorkhan M, Edkins S, Emilsson
V, Eury E, Forsen T, Gertow K, Gigante B, Grant GB, Groves CJ, Guiducci C, Herder C,
Hreidarsson AB, Hui J, James A, Jonsson A, Rathmann W, Klopp N, Kravic J, Krjutškov K,
Langford C, Leander K, Lindholm E, Lobbens S, Männistö S, Mirza G, Mühleisen TW, Musk
B, Parkin M, Rallidis L, Saramies J, Sennblad B, Shah S, Sigurðsson G, Silveira A, Steinbach G,
Thorand B, Trakalo J, Veglia F, Wennauer R, Winckler W, Zabaneh D, Campbell H, van Duijn C,
Uitterlinden AG, Hofman A, Sijbrands E, Abecasis GR, Owen KR, Zeggini E, Trip MD, Forouhi
NG, Syvänen AC, Eriksson JG, Peltonen L, Nöthen MM, Balkau B, Palmer CN, Lyssenko
B. F. Voight
Iyengar SK, Elston RC (2007) The genetic basis of complex traits: rare variants or “common gene,
common disease”? Methods Mol Biol. 376:71–84
Johnson RC, Nelson GW, Troyer JL, Lautenberger JA, Kessing BD, Winkler CA, O’Brien SJ
(2010) Accounting for multiple comparisons in a genome-wide association study (GWAS).
BMC Genomics 11:724–724
Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC,
Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, Li M,
Derohannessian S, de Bakker PI, Bailey SD, Montpetit A, Edmondson AC, Taylor K, Gai X,
Wang SS, Fornage M, Shaikh T, Groop L, Boehnke M, Hall AS, Hattersley AT, Frackelton E,
Patterson N, Chiang CW, Kim CE, Fabsitz RR, Ouwehand W, Price AL, Munroe P, Caulfield
M, Drake T, Boerwinkle E, Reich D, Whitehead AS, Cappola TP, Samani NJ, Lusis AJ, Schadt
E, Wilson JG, Koenig W, McCarthy MI, Kathiresan S, Gabriel SB, Hakonarson H, Anand SS,
Reilly M, Engert JC, Nickerson DA, Rader DJ, Hirschhorn JN, Fitzgerald GA (2008) Concept,
design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale
genomic association studies. PLoS One 3(10):e3583
Kilpeläinen TO, Zillikens MC, Stanákova A, Finucane FM, Ried JS, Langenberg C, Zhang W,
Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U et al (2011) Genetic variation near IRS1
associates with reduced adiposity and an impaired metabolic profile. Nat Genet 43:753–760
Knowler WC, Williams RC, Pettitt DJ, Steinberg AG (1988) Gm3;5,13,14 and type 2 diabetes
mellitus: an association in American Indians with genetic admixture. Am J Hum Genet 43:520–
526
Kruglyak L (1999) Prospects for whole-genome linkage disequilibrium mapping of common
disease genes. Nat Genet 22:139–144
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson
AU, Vedantam S, Raychaudhuri S, Ferreira T et al (2010) Hundreds of variants clustered in
genomic loci and biological pathways affect human height. Nature 467:832–838
Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR (2010) MaCH: using sequence and genotype data
to estimate haplotypes and unobserved genotypes. Genet Epidemiol 34:816–834
Lohmueller KE (2014) The impact of population demography and selection on the genetic
architecture of complex traits. PLoS Genet 10(5):e1004379
Maher B (2008) Personal genomes: the case of the missing heritability. Nature 456:18–21
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos
EM, Cardon LR, Chakravarti A et al (2009) Finding the missing heritability of complex
diseases. Nature 461:747–753
Marchini J, Howie B (2010) Genotype imputation for genome-wide association studies. Nat Rev
Genet 11:499–511
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ,
Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni
S, Kumar A, Lagou V, Langenberg C, Luan J, Lindgren CM, Müller-Nurasyid M, Pechlivanis S,
Rayner NW, Scott LJ, Wiltshire S, Yengo L, Kinnunen L, Rossin EJ, Raychaudhuri S, Johnson
AD, Dimas AS, Loos RJ, Vedantam S, Chen H, Florez JC, Fox C, Liu CT, Rybin D, Couper DJ,
Kao WH, Li M, Cornelis MC, Kraft P, Sun Q, van Dam RM, Stringham HM, Chines PS, Fischer
K, Fontanillas P, Holmen OL, Hunt SE, Jackson AU, Kong A, Lawrence R, Meyer J, Perry JR,
Platou CG, Potter S, Rehnberg E, Robertson N, Sivapalaratnam S, Stanˇ cáková A, Stirrups K,
Thorleifsson G, Tikkanen E, Wood AR, Almgren P, Atalay M, Benediktsson R, Bonnycastle LL,
Burtt N, Carey J, Charpentier G, Crenshaw AT, Doney AS, Dorkhan M, Edkins S, Emilsson
V, Eury E, Forsen T, Gertow K, Gigante B, Grant GB, Groves CJ, Guiducci C, Herder C,
Hreidarsson AB, Hui J, James A, Jonsson A, Rathmann W, Klopp N, Kravic J, Krjutškov K,
Langford C, Leander K, Lindholm E, Lobbens S, Männistö S, Mirza G, Mühleisen TW, Musk
B, Parkin M, Rallidis L, Saramies J, Sennblad B, Shah S, Sigurðsson G, Silveira A, Steinbach G,
Thorand B, Trakalo J, Veglia F, Wennauer R, Winckler W, Zabaneh D, Campbell H, van Duijn C,
Uitterlinden AG, Hofman A, Sijbrands E, Abecasis GR, Owen KR, Zeggini E, Trip MD, Forouhi
NG, Syvänen AC, Eriksson JG, Peltonen L, Nöthen MM, Balkau B, Palmer CN, Lyssenko