225
catheter model. Antimicrob Agents Chemother 59(2):1127–1137. https://doi.org/10.1128/
AAC.03786-14
Levy SB, Marshall B (2004) Antibacterial resistance worldwide: causes, challenges and responses.
Nat Med 10(12 Suppl):S122–S129. https://doi.org/10.1038/nm1145
Lindblad W (2008) Considerations for Determining if a Natural Product Is an Effective WoundHealing Agent. The International Journal of Lower Extremity Wounds 7(2):75–81. https://doi.
org/10.1177/1534734608316028
Lv M, Duan B, Lu K, Wu Y, Zhao Y (2017) Synthesis, DNA-binding and antibacterial activity of
the cell-penetrating peptide HIV-1 tat (49-57). Indian J Pharm Sci 79. https://doi.org/10.4172/
pharmaceutical-sciences.1000305
Malik S, Sidhu PK, Rana JS, Nehra K (2019) Managing urinary tract infections through phage
therapy: a novel approach. Folia Microbiol (Praha) 65:217–231. https://doi.org/10.1007/
s12223-019-00750-y
Mantravadi PK, Kalesh KA, Dobson RCJ, Hudson AO, Parthasarathy A (2019) The quest for
novel antimicrobial compounds: emerging trends in research, development, and technologies.
Antibiotics (Basel) 8(1). https://doi.org/10.3390/antibiotics8010008
Mardirossian M, Grzela R, Giglione C, Meinnel T, Gennaro R, Mergaert P, Scocchi M (2014) The
host antimicrobial peptide Bac71-35 binds to bacterial ribosomal proteins and inhibits protein
synthesis. Chem Biol 21(12):1639–1647. https://doi.org/10.1016/j.chembiol.2014.10.009
Mayers D, Sobel J, Ouellette M, Kaye K, Marchaim D (2017) Antimicrobial drug resistance:
mechanisms of drug resistance, volume 1. Springer-Verlag, Berlin Heidelberg
McPhee JB, Tamber S, Brazas MD, Lewenza S, Hancock REW (2009) Antibiotic resistance due to
reduced uptake, pp 97–110. https://doi.org/10.1007/978-1-59745-180-2_9
Meng J, Da F, Ma X, Wang N, Wang Y, Zhang H et al (2015) Antisense growth inhibition of
methicillin- resistant Staphylococcus aureus by locked nucleic acid conjugated with cellpenetrating peptide as a novel FtsZ inhibitor. Antimicrob Agents Chemother 59(2):914–922.
https://doi.org/10.1128/AAC.03781-14
Meyers S, Shih J, Neher JO, Safranek S (2018) Clinical inquiries: how effective and safe is fecal
microbial transplant in preventing C difficile recurrence? J Fam Pract 67(6):386–388
Moller-Olsen C, Ho SFS, Shukla RD, Feher T, Sagona AP (2018) Engineered K1F bacteriophages
kill intracellular Escherichia coli K1 in human epithelial cells. Sci Rep 8(1):17559. https://doi.
org/10.1038/s41598-018-35859-6
Mullish BH, Quraishi MN, Segal JP, McCune VL, Baxter M, Marsden GL et al (2018) The use
of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile
infection and other potential indications: joint British Society of Gastroenterology (BSG) and
Healthcare Infection Society (HIS) guidelines. Gut 67(11):1920–1941. https://doi.org/10.1136/
gutjnl-2018-316818
Munita JM, Arias CA (2016) Mechanisms of antibiotic resistance. Microbiol Spectrosc 4(2).
https://doi.org/10.1128/microbiolspec.VMBF-0016-2015
Nakase I, Akita H, Kogure K, Graslund A, Langel U, Harashima H, Futaki S (2012) Efficient intracellular delivery of nucleic acid pharmaceuticals using cell-penetrating peptides. Acc Chem
Res 45(7):1132–1139. https://doi.org/10.1021/ar200256e
Nan YH, Park IS, Hahm KS, Shin SY (2011) Antimicrobial activity, bactericidal mechanism and
LPS-neutralizing activity of the cell-penetrating peptide pVEC and its analogs. J Pept Sci
17(12):812–817. https://doi.org/10.1002/psc.1408
Narayanan S, Modak JK, Ryan CS, Garcia-Bustos J, Davies JK, Roujeinikova A (2014)
Mechanism of Escherichia coli resistance to Pyrrhocoricin. Antimicrob Agents Chemother
58(5):2754–2762. https://doi.org/10.1128/AAC.02565-13
Okeke IN, Klugman KP, Bhutta ZA, Duse AG, Jenkins P, O’Brien TF et al (2005) Antimicrobial
resistance in developing countries. Part II: strategies for containment. Lancet Infect Dis
5(9):568–580. https://doi.org/10.1016/S1473-3099(05)70217-6
Paik J, Duggan S (2019) Volanesorsen: first global approval. Drugs 79:1349–1354. https://doi.
org/10.1007/s40265-019-01168-z
9 Drug Discovery for Targeting Drug Resistant Bacteria
catheter model. Antimicrob Agents Chemother 59(2):1127–1137. https://doi.org/10.1128/
AAC.03786-14
Levy SB, Marshall B (2004) Antibacterial resistance worldwide: causes, challenges and responses.
Nat Med 10(12 Suppl):S122–S129. https://doi.org/10.1038/nm1145
Lindblad W (2008) Considerations for Determining if a Natural Product Is an Effective WoundHealing Agent. The International Journal of Lower Extremity Wounds 7(2):75–81. https://doi.
org/10.1177/1534734608316028
Lv M, Duan B, Lu K, Wu Y, Zhao Y (2017) Synthesis, DNA-binding and antibacterial activity of
the cell-penetrating peptide HIV-1 tat (49-57). Indian J Pharm Sci 79. https://doi.org/10.4172/
pharmaceutical-sciences.1000305
Malik S, Sidhu PK, Rana JS, Nehra K (2019) Managing urinary tract infections through phage
therapy: a novel approach. Folia Microbiol (Praha) 65:217–231. https://doi.org/10.1007/
s12223-019-00750-y
Mantravadi PK, Kalesh KA, Dobson RCJ, Hudson AO, Parthasarathy A (2019) The quest for
novel antimicrobial compounds: emerging trends in research, development, and technologies.
Antibiotics (Basel) 8(1). https://doi.org/10.3390/antibiotics8010008
Mardirossian M, Grzela R, Giglione C, Meinnel T, Gennaro R, Mergaert P, Scocchi M (2014) The
host antimicrobial peptide Bac71-35 binds to bacterial ribosomal proteins and inhibits protein
synthesis. Chem Biol 21(12):1639–1647. https://doi.org/10.1016/j.chembiol.2014.10.009
Mayers D, Sobel J, Ouellette M, Kaye K, Marchaim D (2017) Antimicrobial drug resistance:
mechanisms of drug resistance, volume 1. Springer-Verlag, Berlin Heidelberg
McPhee JB, Tamber S, Brazas MD, Lewenza S, Hancock REW (2009) Antibiotic resistance due to
reduced uptake, pp 97–110. https://doi.org/10.1007/978-1-59745-180-2_9
Meng J, Da F, Ma X, Wang N, Wang Y, Zhang H et al (2015) Antisense growth inhibition of
methicillin- resistant Staphylococcus aureus by locked nucleic acid conjugated with cellpenetrating peptide as a novel FtsZ inhibitor. Antimicrob Agents Chemother 59(2):914–922.
https://doi.org/10.1128/AAC.03781-14
Meyers S, Shih J, Neher JO, Safranek S (2018) Clinical inquiries: how effective and safe is fecal
microbial transplant in preventing C difficile recurrence? J Fam Pract 67(6):386–388
Moller-Olsen C, Ho SFS, Shukla RD, Feher T, Sagona AP (2018) Engineered K1F bacteriophages
kill intracellular Escherichia coli K1 in human epithelial cells. Sci Rep 8(1):17559. https://doi.
org/10.1038/s41598-018-35859-6
Mullish BH, Quraishi MN, Segal JP, McCune VL, Baxter M, Marsden GL et al (2018) The use
of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile
infection and other potential indications: joint British Society of Gastroenterology (BSG) and
Healthcare Infection Society (HIS) guidelines. Gut 67(11):1920–1941. https://doi.org/10.1136/
gutjnl-2018-316818
Munita JM, Arias CA (2016) Mechanisms of antibiotic resistance. Microbiol Spectrosc 4(2).
https://doi.org/10.1128/microbiolspec.VMBF-0016-2015
Nakase I, Akita H, Kogure K, Graslund A, Langel U, Harashima H, Futaki S (2012) Efficient intracellular delivery of nucleic acid pharmaceuticals using cell-penetrating peptides. Acc Chem
Res 45(7):1132–1139. https://doi.org/10.1021/ar200256e
Nan YH, Park IS, Hahm KS, Shin SY (2011) Antimicrobial activity, bactericidal mechanism and
LPS-neutralizing activity of the cell-penetrating peptide pVEC and its analogs. J Pept Sci
17(12):812–817. https://doi.org/10.1002/psc.1408
Narayanan S, Modak JK, Ryan CS, Garcia-Bustos J, Davies JK, Roujeinikova A (2014)
Mechanism of Escherichia coli resistance to Pyrrhocoricin. Antimicrob Agents Chemother
58(5):2754–2762. https://doi.org/10.1128/AAC.02565-13
Okeke IN, Klugman KP, Bhutta ZA, Duse AG, Jenkins P, O’Brien TF et al (2005) Antimicrobial
resistance in developing countries. Part II: strategies for containment. Lancet Infect Dis
5(9):568–580. https://doi.org/10.1016/S1473-3099(05)70217-6
Paik J, Duggan S (2019) Volanesorsen: first global approval. Drugs 79:1349–1354. https://doi.
org/10.1007/s40265-019-01168-z
9 Drug Discovery for Targeting Drug Resistant Bacteria