205
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2020
H. Panwar et al. (eds.), Sustainable Agriculture Reviews 46, Sustainable
Agriculture Reviews 46, https://doi.org/10.1007/978-3-030-53024-2_9
Chapter 9
Drug Discovery for Targeting Drug
Resistant Bacteria
Aikaterini Valsamatzi-Panagiotou, Katya B. Popova, and Robert Penchovsky
Abstract The alternative approaches for antibacterial drug discovery have a huge
potential to develop novel antibacterial agents against multi drug resistant human
pathogenic bacteria that are much needed to tackle the urgent threats of multi drug
resistant human pathogenic bacteria. We may be able to develop much faster novel
antibiotics against multi drug resistant human pathogenic bacteria using these alternative methods than that based on small molecule drug discovery. The alternative
methods for antibacterial drug discovery can be used to target new molecules in
pathogenic bacteria such as bacterial riboswitches. The combination of novel mechanisms of antibacterial drug action, with novel molecules targets, can result in the
development of novel antibiotics against which bacteria have yet not developed any
kind of resistance.
In this book chapter, we present novel methods for antibacterial drug discovery
against antimicrobial resistant bacteria based on alternative strategies for antibacterial drug discovery. These include the application of antisense oligonucleotides as
antibacterial agents, fecal microbiota transplantation, and antimicrobial peptides
and cell penetrating peptides with antibacterial activity. We also present the main
ways of antibiotics misuse that lead to the development of antimicrobial resistance.
Keywords Drug discovery · Antimicrobial resistance: Riboswitches · Antisense
oligonucleotides · Antibiotics
Aikaterini Valsamatzi-Panagiotou and Katya B. Popova contributed equally with all other
contributors.
A. Valsamatzi-Panagiotou · K. B. Popova · R. Penchovsky (*)
Department of Genetics, Faculty of Biology, Sofia University “St. Kliment Ohridski”,
Sofia, Bulgaria
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2020
H. Panwar et al. (eds.), Sustainable Agriculture Reviews 46, Sustainable
Agriculture Reviews 46, https://doi.org/10.1007/978-3-030-53024-2_9
Chapter 9
Drug Discovery for Targeting Drug
Resistant Bacteria
Aikaterini Valsamatzi-Panagiotou, Katya B. Popova, and Robert Penchovsky
Abstract The alternative approaches for antibacterial drug discovery have a huge
potential to develop novel antibacterial agents against multi drug resistant human
pathogenic bacteria that are much needed to tackle the urgent threats of multi drug
resistant human pathogenic bacteria. We may be able to develop much faster novel
antibiotics against multi drug resistant human pathogenic bacteria using these alternative methods than that based on small molecule drug discovery. The alternative
methods for antibacterial drug discovery can be used to target new molecules in
pathogenic bacteria such as bacterial riboswitches. The combination of novel mechanisms of antibacterial drug action, with novel molecules targets, can result in the
development of novel antibiotics against which bacteria have yet not developed any
kind of resistance.
In this book chapter, we present novel methods for antibacterial drug discovery
against antimicrobial resistant bacteria based on alternative strategies for antibacterial drug discovery. These include the application of antisense oligonucleotides as
antibacterial agents, fecal microbiota transplantation, and antimicrobial peptides
and cell penetrating peptides with antibacterial activity. We also present the main
ways of antibiotics misuse that lead to the development of antimicrobial resistance.
Keywords Drug discovery · Antimicrobial resistance: Riboswitches · Antisense
oligonucleotides · Antibiotics
Aikaterini Valsamatzi-Panagiotou and Katya B. Popova contributed equally with all other
contributors.
A. Valsamatzi-Panagiotou · K. B. Popova · R. Penchovsky (*)
Department of Genetics, Faculty of Biology, Sofia University “St. Kliment Ohridski”,
Sofia, Bulgaria