199
Ralstonia solanacearum Phc cell density sensing system. Mol Microbiol 38:359–367. https://
doi.org/10.1046/j.1365-2958.2000.02131.x
Giménez-Bastida JA, Truchado P, Larrosa M, Espín JC, Tomás-Barberán FA, Allende A, GarcíaConesa MT (2012) Urolithins, ellagitannin metabolites produced by colon microbiota, inhibit
quorum-sensing in Yersinia enterocolitica: phenotypic response and associated molecular
changes. Food Chem 132:1465–1474. https://doi.org/10.1016/J.FOODCHEM.2011.12.003
Gominet M, Slamti L, Gilois N, Rose M, Lereclus D (2001) Oligopeptide permease is required
for expression of the Bacillus thuringiensis plcR regulon and for virulence. Mol Microbiol
40:963–975. https://doi.org/10.1046/j.1365-2958.2001.02440.x
González Barrios AF, Zuo R, Hashimoto Y, Yang L, Bentley WE, Wood TK (2006) Autoinducer 2
controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022). J Bacteriol 188:305–316. https://doi.org/10.1128/JB.188.1.305-316.2006
Gordon CP, Williams P, Chan WC (2013) Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective. J Med Chem 56:1389–1404. https://doi.org/10.1021/
jm3014635
Harjai K, Kumar R, Singh S (2010) Garlic blocks quorum-sensing and attenuates the virulence of
Pseudomonas aeruginosa. FEMS Immunology & Medical Microbiology 58:161–168. https://
doi.org/10.1111/j.1574-695X.2009.00614.x
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Cámara M (2011) Quinolones:
from antibiotics to autoinducers. FEMS Microbiol Rev 35:247–274. https://doi.
org/10.1111/j.1574-6976.2010.00247.x
Hraiech S, Hiblot J, Lafleur J, Lepidi H, Papazian L, Rolain J-M, Raoult D, Elias M, Silby MW,
Bzdrenga J, Bregeon F, Chabriere E (2014) Inhaled Lactonase reduces Pseudomonas aeruginosa quorum-sensing and mortality in rat pneumonia. PLoS One 9:e107125. https://doi.
org/10.1371/journal.pone.0107125
Ishige K, Nagasawa S, Tokishita S, Mizuno T (1994) A novel device of bacterial signal transducers. EMBO J 13:5195–5202. https://doi.org/10.1002/j.1460-2075.1994.tb06850.x
Jakobsen TH, Bragason SK, Phipps RK, Christensen LD, van Gennip M, Alhede M, Skindersoe M,
Larsen TO, Høiby N, Bjarnsholt T, Givskov M (2012a) Food as a source for quorum- sensing
inhibitors: Iberin from horseradish revealed as a quorum-sensing inhibitor of Pseudomonas
aeruginosa. Appl Environ Microbiol 78:2410–2421. https://doi.org/10.1128/AEM.05992-11
Jakobsen TH, van Gennip M, Phipps RK, Shanmugham MS, Christensen LD, Alhede M,
Skindersoe ME, Rasmussen TB, Friedrich K, Uthe F, Jensen PØ, Moser C, Nielsen KF, Eberl
L, Larsen TO, Tanner D, Høiby N, Bjarnsholt T, Givskov M (2012b) Ajoene, a Sulfur-rich molecule from garlic, inhibits genes controlled by quorum-sensing. Antimicrob Agents Chemother
56:2314–2325. https://doi.org/10.1128/AAC.05919-11
Jiang Q, Chen J, Yang C, Yin Y, Yao K (2019) Quorum-sensing: a prospective therapeutic target for
bacterial diseases. Biomed Res Int 2019:1–15. https://doi.org/10.1155/2019/2015978
Kaplan F, Badri DV, Zachariah C, Ajredini R, Sandoval FJ, Roje S, Levine LH, Zhang F, Robinette
SL, Alborn HT, Zhao W, Stadler M, Nimalendran R, Dossey AT, Brüschweiler R, Vivanco
JM, Edison AS (2009) Bacterial attraction and quorum-sensing inhibition in Caenorhabditis
elegans exudates. J Chem Ecol 35:878–892. https://doi.org/10.1007/s10886-009-9670-0
Kaplan HB, Greenberg EP (1985) Diffusion of autoinducer is involved in regulation of the Vibrio
fischeri luminescence system. J Bacteriol 163:1210–1214
Kendall MM, Sperandio V (2007) Quorum-sensing by enteric pathogens. Curr Opin Gastroenterol
23:10–15. https://doi.org/10.1097/MOG.0b013e3280118289
Keshavan ND, Chowdhary PK, Haines DC, Gonzalez JE (2005) L-Canavanine made by Medicago
sativa interferes with quorum-sensing in Sinorhizobium meliloti. J Bacteriol 187:8427–8436.
https://doi.org/10.1128/JB.187.24.8427-8436.2005
de Kievit TR, Iglewski BH (2000) Bacterial quorum-sensing in pathogenic relationships. Infect
Immun 68:4839–4849. https://doi.org/10.1128/IAI.68.9.4839-4849.2000
8 Intrusion of Bacterial Quorum-Sensing for Antimicrobial Resistance Mitigation…
Ralstonia solanacearum Phc cell density sensing system. Mol Microbiol 38:359–367. https://
doi.org/10.1046/j.1365-2958.2000.02131.x
Giménez-Bastida JA, Truchado P, Larrosa M, Espín JC, Tomás-Barberán FA, Allende A, GarcíaConesa MT (2012) Urolithins, ellagitannin metabolites produced by colon microbiota, inhibit
quorum-sensing in Yersinia enterocolitica: phenotypic response and associated molecular
changes. Food Chem 132:1465–1474. https://doi.org/10.1016/J.FOODCHEM.2011.12.003
Gominet M, Slamti L, Gilois N, Rose M, Lereclus D (2001) Oligopeptide permease is required
for expression of the Bacillus thuringiensis plcR regulon and for virulence. Mol Microbiol
40:963–975. https://doi.org/10.1046/j.1365-2958.2001.02440.x
González Barrios AF, Zuo R, Hashimoto Y, Yang L, Bentley WE, Wood TK (2006) Autoinducer 2
controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022). J Bacteriol 188:305–316. https://doi.org/10.1128/JB.188.1.305-316.2006
Gordon CP, Williams P, Chan WC (2013) Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective. J Med Chem 56:1389–1404. https://doi.org/10.1021/
jm3014635
Harjai K, Kumar R, Singh S (2010) Garlic blocks quorum-sensing and attenuates the virulence of
Pseudomonas aeruginosa. FEMS Immunology & Medical Microbiology 58:161–168. https://
doi.org/10.1111/j.1574-695X.2009.00614.x
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Cámara M (2011) Quinolones:
from antibiotics to autoinducers. FEMS Microbiol Rev 35:247–274. https://doi.
org/10.1111/j.1574-6976.2010.00247.x
Hraiech S, Hiblot J, Lafleur J, Lepidi H, Papazian L, Rolain J-M, Raoult D, Elias M, Silby MW,
Bzdrenga J, Bregeon F, Chabriere E (2014) Inhaled Lactonase reduces Pseudomonas aeruginosa quorum-sensing and mortality in rat pneumonia. PLoS One 9:e107125. https://doi.
org/10.1371/journal.pone.0107125
Ishige K, Nagasawa S, Tokishita S, Mizuno T (1994) A novel device of bacterial signal transducers. EMBO J 13:5195–5202. https://doi.org/10.1002/j.1460-2075.1994.tb06850.x
Jakobsen TH, Bragason SK, Phipps RK, Christensen LD, van Gennip M, Alhede M, Skindersoe M,
Larsen TO, Høiby N, Bjarnsholt T, Givskov M (2012a) Food as a source for quorum- sensing
inhibitors: Iberin from horseradish revealed as a quorum-sensing inhibitor of Pseudomonas
aeruginosa. Appl Environ Microbiol 78:2410–2421. https://doi.org/10.1128/AEM.05992-11
Jakobsen TH, van Gennip M, Phipps RK, Shanmugham MS, Christensen LD, Alhede M,
Skindersoe ME, Rasmussen TB, Friedrich K, Uthe F, Jensen PØ, Moser C, Nielsen KF, Eberl
L, Larsen TO, Tanner D, Høiby N, Bjarnsholt T, Givskov M (2012b) Ajoene, a Sulfur-rich molecule from garlic, inhibits genes controlled by quorum-sensing. Antimicrob Agents Chemother
56:2314–2325. https://doi.org/10.1128/AAC.05919-11
Jiang Q, Chen J, Yang C, Yin Y, Yao K (2019) Quorum-sensing: a prospective therapeutic target for
bacterial diseases. Biomed Res Int 2019:1–15. https://doi.org/10.1155/2019/2015978
Kaplan F, Badri DV, Zachariah C, Ajredini R, Sandoval FJ, Roje S, Levine LH, Zhang F, Robinette
SL, Alborn HT, Zhao W, Stadler M, Nimalendran R, Dossey AT, Brüschweiler R, Vivanco
JM, Edison AS (2009) Bacterial attraction and quorum-sensing inhibition in Caenorhabditis
elegans exudates. J Chem Ecol 35:878–892. https://doi.org/10.1007/s10886-009-9670-0
Kaplan HB, Greenberg EP (1985) Diffusion of autoinducer is involved in regulation of the Vibrio
fischeri luminescence system. J Bacteriol 163:1210–1214
Kendall MM, Sperandio V (2007) Quorum-sensing by enteric pathogens. Curr Opin Gastroenterol
23:10–15. https://doi.org/10.1097/MOG.0b013e3280118289
Keshavan ND, Chowdhary PK, Haines DC, Gonzalez JE (2005) L-Canavanine made by Medicago
sativa interferes with quorum-sensing in Sinorhizobium meliloti. J Bacteriol 187:8427–8436.
https://doi.org/10.1128/JB.187.24.8427-8436.2005
de Kievit TR, Iglewski BH (2000) Bacterial quorum-sensing in pathogenic relationships. Infect
Immun 68:4839–4849. https://doi.org/10.1128/IAI.68.9.4839-4849.2000
8 Intrusion of Bacterial Quorum-Sensing for Antimicrobial Resistance Mitigation…