188
database, there are 1382 entries of 182 unique QSSMs from 215 organisms. It
includes the biological information like genes, identification assays, preliminary
bioassays, and applications as well as chemical details of QSSMs such as SMILES,
IUPAC names, and structures. The database provides easy data retrieval and comparison of different signaling molecules due to the user friendly graphical user interface. SigMol is helpful to the scientific community associated with the field of
quorum sensing and their pharmacological applications (Rajput et al. 2016).
8.5.2 Quorumpeps Database
Owing to advancements in this field and numerous successful reports for quorum
sensing usage, a public database such as Quorumpeps, was urgently needed.
Quorumpeps (http://quorumpeps.ugent.be) is a database of experimentally proved
quorum sensing signaling peptides. The browser of the database is user friendly
with several search field options including sequence, trivial name, smiles, molecular
formula, receptor, method, origin, literature, etc. Quorumpeps database provides the
chemical information of QSSMs such as IUPAC names, structures, molecular formulas, trivial names, and smiles. In addition to that, it also provides the related
information of QSSMs like the origin of microbial species, functionality related to
method, result, and receptor, peptide links and chemical characteristics (3D-structurederived physicochemical properties). The chemical diversity of quorum sensing signaling molecules can be used to develop the new therapeutically significant
molecules. Quorumpeps database can be a valuable tool to study the quantitative
structure-property relationships of quorum sensing signaling molecules. This database is updated quarterly by the authors to ensure up-to-date information to the
researchers (Wynendaele et al. 2013).
8.6 Role of Quorum Sensing Inhibitors in Mitigation
of Antimicrobial Resistance
Quorum sensing is particularly involved in the regulation of the expression of virulence factors, biofilm formation, the disruption of bacterial communication, production of siderophores and protease in response to the population density of
microorganisms. The autoinducing peptides in Gram positive bacteria are strains
and species specific such as Staphylococcus spp., Clostridium spp., or Enterococcus
spp. employ different peptides for signaling (Monnet et al. 2014). Gram negative
bacteria including Acinetobacter spp., Burkholderia spp., Enterobacteria spp.,
Pseudomonas spp., etc. use the different class of signaling molecules as described
in the above sections. In addition to acyl homoserine lactones, bacteria such as
Legionella spp. and Vibrio spp. also, employ signaling molecules such as ketones
S. Kumar et al.
database, there are 1382 entries of 182 unique QSSMs from 215 organisms. It
includes the biological information like genes, identification assays, preliminary
bioassays, and applications as well as chemical details of QSSMs such as SMILES,
IUPAC names, and structures. The database provides easy data retrieval and comparison of different signaling molecules due to the user friendly graphical user interface. SigMol is helpful to the scientific community associated with the field of
quorum sensing and their pharmacological applications (Rajput et al. 2016).
8.5.2 Quorumpeps Database
Owing to advancements in this field and numerous successful reports for quorum
sensing usage, a public database such as Quorumpeps, was urgently needed.
Quorumpeps (http://quorumpeps.ugent.be) is a database of experimentally proved
quorum sensing signaling peptides. The browser of the database is user friendly
with several search field options including sequence, trivial name, smiles, molecular
formula, receptor, method, origin, literature, etc. Quorumpeps database provides the
chemical information of QSSMs such as IUPAC names, structures, molecular formulas, trivial names, and smiles. In addition to that, it also provides the related
information of QSSMs like the origin of microbial species, functionality related to
method, result, and receptor, peptide links and chemical characteristics (3D-structurederived physicochemical properties). The chemical diversity of quorum sensing signaling molecules can be used to develop the new therapeutically significant
molecules. Quorumpeps database can be a valuable tool to study the quantitative
structure-property relationships of quorum sensing signaling molecules. This database is updated quarterly by the authors to ensure up-to-date information to the
researchers (Wynendaele et al. 2013).
8.6 Role of Quorum Sensing Inhibitors in Mitigation
of Antimicrobial Resistance
Quorum sensing is particularly involved in the regulation of the expression of virulence factors, biofilm formation, the disruption of bacterial communication, production of siderophores and protease in response to the population density of
microorganisms. The autoinducing peptides in Gram positive bacteria are strains
and species specific such as Staphylococcus spp., Clostridium spp., or Enterococcus
spp. employ different peptides for signaling (Monnet et al. 2014). Gram negative
bacteria including Acinetobacter spp., Burkholderia spp., Enterobacteria spp.,
Pseudomonas spp., etc. use the different class of signaling molecules as described
in the above sections. In addition to acyl homoserine lactones, bacteria such as
Legionella spp. and Vibrio spp. also, employ signaling molecules such as ketones
S. Kumar et al.