126
Li P, Fung YME, Yin XH, Seneviratne CJ, Che CM, Jin LJ (2018) Controlled cellular redox,
repressive hemin utilization and adaptive stress responses are crucial to metronidazole tolerance of Porphyromonas gingivalis persisters. J Clin Periodontol 45(10):1211–1221. https://doi.
org/10.1111/jcpe.13002
Lilley KS, Friedman DB (2004) All about DIGE: quantification technology for differentialdisplay 2D-gel proteomics. Expert Rev Proteomics 1(4):401–409. https://doi.
org/10.1586/14789450.1.4.401
Ma C, Sim S, Shi W, Du L, Xing D, Zhang Y (2010) Energy production genes sucB and ubiF are
involved in persister survival and tolerance to multiple antibiotics and stresses in Escherichia
coli. FEMS Microbiol Lett 303(1):33–40. https://doi.org/10.1111/j.1574-6968.2009.01857.x
Maglica Z, Ozdemir E, McKinney JD (2015) Single-cell tracking reveals antibiotic-induced changes
in mycobacterial energy metabolism. MBio 6(1). https://doi.org/10.1128/mBio.02236-14
Maisonneuve E, Gerdes K (2014) Molecular mechanisms underlying bacterial persisters. Cell
157(3):539–548. https://doi.org/10.1016/j.cell.2014.02.050
Manina G, Dhar N, McKinney JD (2015) Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms. Cell Host
Microbe 17(1):32–46. https://doi.org/10.1016/j.chom.2014.11.016
Manuel J, Zhanel GG, de Kievit T (2010) Cadaverine suppresses persistence to carboxypenicillins
in Pseudomonas aeruginosa PAO1. Antimicrob Agents Chemother 54(12):5173–5179. https://
doi.org/10.1128/AAC.01751-09
Matilla MA (2018) Shedding light into the mechanisms of formation and resuscitation of persistent
bacterial cells. Environ Microbiol 20(9):3129–3131. https://doi.org/10.1111/1462-2920.14334
Matsumoto S, Kawai Y, Miyagawa S, Iwamoto Y, Okuda S, Sanchez-Gorostiaga A, Vicente M,
Tsuneda S (2018) Unique transcriptional profile of native persisters in Escherichia coli. J
Biosci Bioeng 125(1):15–22. https://doi.org/10.1016/j.jbiosc.2017.07.015
Mazurkiewicz P, Tang CM, Boone C, Holden DW (2006) Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nat Rev Genet 7(12):929–939. https://doi.
org/10.1038/nrg1984
McAdam PR, Holmes A, Templeton KE, Fitzgerald JR (2011) Adaptive evolution of Staphylococcus
aureus during chronic endobronchial infection of a cystic fibrosis patient. PLoS One 6(9).
https://doi.org/10.1371/journal.pone.0024301
Mojsoska B, Cameron DR, Bartell JA, Haagensen JA, Sommer LM, Lewis K, Molin S, Johansen
HK (2019) The high persister phenotype of Pseudomonas aeruginosa is associated with
increased fitness and persistence in cystic fibrosis airways. bioRxiv:561589
Moker N, Dean CR, Tao JS (2010) Pseudomonas aeruginosa increases formation of multidrugtolerant persister cells in response to quorum-sensing signaling molecules. J Bacteriol
192(7):1946–1955. https://doi.org/10.1128/Jb.01231-09
Molina-Quiroz RC, Lazinski DW, Camilli A, Levy SB (2016) Transposon-sequencing analysis
unveils novel genes involved in the generation of persister cells in uropathogenic Escherichia
coli. Antimicrob Agents Chemother 60(11):6907–6910. https://doi.org/10.1128/Aac.01617-16
Moyed HS, Bertrand KP (1983) HipA, a newly recognized gene of Escherichia-coli K-12 that
affects frequency of persistence after inhibition of murein synthesis. J Bacteriol 155(2):768–775
Muller B, Borrell S, Rose G, Gagneux S (2013) The heterogeneous evolution of multidrugresistant Mycobacterium tuberculosis. Trends Genet 29(3):160–169. https://doi.org/10.1016/j.
tig.2012.11.005
Nandakumar M, Nathan C, Rhee KY (2014) Isocitrate lyase mediates broad antibiotic tolerance in
Mycobacterium tuberculosis. Nat Commun 5. https://doi.org/10.1038/ncomms5306
Page R, Peti W (2016) Toxin-antitoxin systems in bacterial growth arrest and persistence. Nat
Chem Biol 12(4):208–214. https://doi.org/10.1038/Nchembio.2044
Paranjape SS, Shashidhar R (2019) Comparison of starvation-induced persister cells with
antibiotic- induced persister cells. Curr Microbiol 76(12):1495–1502. https://doi.org/10.1007/
s00284-019-01777-7
X. Duan et al.
Li P, Fung YME, Yin XH, Seneviratne CJ, Che CM, Jin LJ (2018) Controlled cellular redox,
repressive hemin utilization and adaptive stress responses are crucial to metronidazole tolerance of Porphyromonas gingivalis persisters. J Clin Periodontol 45(10):1211–1221. https://doi.
org/10.1111/jcpe.13002
Lilley KS, Friedman DB (2004) All about DIGE: quantification technology for differentialdisplay 2D-gel proteomics. Expert Rev Proteomics 1(4):401–409. https://doi.
org/10.1586/14789450.1.4.401
Ma C, Sim S, Shi W, Du L, Xing D, Zhang Y (2010) Energy production genes sucB and ubiF are
involved in persister survival and tolerance to multiple antibiotics and stresses in Escherichia
coli. FEMS Microbiol Lett 303(1):33–40. https://doi.org/10.1111/j.1574-6968.2009.01857.x
Maglica Z, Ozdemir E, McKinney JD (2015) Single-cell tracking reveals antibiotic-induced changes
in mycobacterial energy metabolism. MBio 6(1). https://doi.org/10.1128/mBio.02236-14
Maisonneuve E, Gerdes K (2014) Molecular mechanisms underlying bacterial persisters. Cell
157(3):539–548. https://doi.org/10.1016/j.cell.2014.02.050
Manina G, Dhar N, McKinney JD (2015) Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms. Cell Host
Microbe 17(1):32–46. https://doi.org/10.1016/j.chom.2014.11.016
Manuel J, Zhanel GG, de Kievit T (2010) Cadaverine suppresses persistence to carboxypenicillins
in Pseudomonas aeruginosa PAO1. Antimicrob Agents Chemother 54(12):5173–5179. https://
doi.org/10.1128/AAC.01751-09
Matilla MA (2018) Shedding light into the mechanisms of formation and resuscitation of persistent
bacterial cells. Environ Microbiol 20(9):3129–3131. https://doi.org/10.1111/1462-2920.14334
Matsumoto S, Kawai Y, Miyagawa S, Iwamoto Y, Okuda S, Sanchez-Gorostiaga A, Vicente M,
Tsuneda S (2018) Unique transcriptional profile of native persisters in Escherichia coli. J
Biosci Bioeng 125(1):15–22. https://doi.org/10.1016/j.jbiosc.2017.07.015
Mazurkiewicz P, Tang CM, Boone C, Holden DW (2006) Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nat Rev Genet 7(12):929–939. https://doi.
org/10.1038/nrg1984
McAdam PR, Holmes A, Templeton KE, Fitzgerald JR (2011) Adaptive evolution of Staphylococcus
aureus during chronic endobronchial infection of a cystic fibrosis patient. PLoS One 6(9).
https://doi.org/10.1371/journal.pone.0024301
Mojsoska B, Cameron DR, Bartell JA, Haagensen JA, Sommer LM, Lewis K, Molin S, Johansen
HK (2019) The high persister phenotype of Pseudomonas aeruginosa is associated with
increased fitness and persistence in cystic fibrosis airways. bioRxiv:561589
Moker N, Dean CR, Tao JS (2010) Pseudomonas aeruginosa increases formation of multidrugtolerant persister cells in response to quorum-sensing signaling molecules. J Bacteriol
192(7):1946–1955. https://doi.org/10.1128/Jb.01231-09
Molina-Quiroz RC, Lazinski DW, Camilli A, Levy SB (2016) Transposon-sequencing analysis
unveils novel genes involved in the generation of persister cells in uropathogenic Escherichia
coli. Antimicrob Agents Chemother 60(11):6907–6910. https://doi.org/10.1128/Aac.01617-16
Moyed HS, Bertrand KP (1983) HipA, a newly recognized gene of Escherichia-coli K-12 that
affects frequency of persistence after inhibition of murein synthesis. J Bacteriol 155(2):768–775
Muller B, Borrell S, Rose G, Gagneux S (2013) The heterogeneous evolution of multidrugresistant Mycobacterium tuberculosis. Trends Genet 29(3):160–169. https://doi.org/10.1016/j.
tig.2012.11.005
Nandakumar M, Nathan C, Rhee KY (2014) Isocitrate lyase mediates broad antibiotic tolerance in
Mycobacterium tuberculosis. Nat Commun 5. https://doi.org/10.1038/ncomms5306
Page R, Peti W (2016) Toxin-antitoxin systems in bacterial growth arrest and persistence. Nat
Chem Biol 12(4):208–214. https://doi.org/10.1038/Nchembio.2044
Paranjape SS, Shashidhar R (2019) Comparison of starvation-induced persister cells with
antibiotic- induced persister cells. Curr Microbiol 76(12):1495–1502. https://doi.org/10.1007/
s00284-019-01777-7
X. Duan et al.