16. Santi I, McKinney JD (2015) Chromosome
organization and replisome dynamics in Mycobacterium smegmatis. mBio 6:e01999–e01914
17. Wells RM, Jones CM, Xi Z et al (2013) Discovery of a siderophore export system essential
for virulence of Mycobacterium tuberculosis.
PLoS Pathog 9:e1003120
18. Jones CM, Niederweis M (2010) Role of porins in iron uptake by Mycobacterium smegmatis.
J Bacteriol 192:6411–6417
19. MacGilvary NJ, Kevorkian YL, Tan S (2019)
Potassium response and homeostasis in Mycobacterium tuberculosis modulate environmental
adaptation and is important for host colonization. PLoS Pathog 15:e1007591
20. Abramovitch RB, Rohde KH, Hsu FF et al
(2011) aprABC: a Mycobacterium tuberculosis
complex-specific
locus
that
modulates
pH-driven adaptation to the macrophage phagosome. Mol Microbiol l80:678–694
21. Bhaskar A, Chawla M, Mehta M et al (2014)
Reengineering redox sensitive GFP to measure
mycothiol redox potential of Mycobacterium
tuberculosis during infection. PLoS Pathog 10:
e1003902
22. Vandal OH, Pierini LM, Schnappinger D et al
(2008) A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nat Med 14:849–854
23. Huang L, Nazarova EV, Tan S et al (2018)
Growth of Mycobacterium tuberculosis in vivo
segregates with host macrophage metabolism
and ontogeny. J Exp Med 215:1135–1152
24. Zheng H, Colvin CJ, Johnson BK et al (2017)
Inhibitors of Mycobacterium tuberculosis
DosRST signaling and persistence. Nat Chem
Bio l13:218–225
25. Johnson BK, Colvin CJ, Needle DB et al
(2015) The carbonic anhydrase inhibitor
ethoxzolamide inhibits the Mycobacterium
tuberculosis PhoPR regulon and Esx-1 secretion and attenuates virulence. Antimicrob
Agents Chemother 59:4436–4445
26. Liu Y, Tan S, Huang L et al (2016) Immune
activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both
in vitro and in vivo. J Exp Med 213:809–825
27. Lenaerts A, Barry CE 3rd, Dartois V (2015)
Heterogeneity in tuberculosis pathology,
microenvironments and therapeutic responses.
Immunol Rev 264:288–307
28. Lin PL, Ford CB, Coleman MT et al (2014)
Sterilization of granulomas is common in active
and latent tuberculosis despite within-host
variability in bacterial killing. Nat Med
20:75–79
29. Cadena AM, Fortune SM, Flynn JL (2017)
Heterogeneity in tuberculosis. Nat Rev Immunol 17:691–702
30. Manina G, Dhar N, McKinney JD (2015)
Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity
and induce nongrowing metabolically active
forms. Cell Host Microbe 17:32–46
31. Marakalala MJ, Martinez FO, Pluddemann A
et al (2018) Macrophage heterogeneity in the
immunopathogenesis of tuberculosis. Front
Microbiol 9:1028
32. Irwin SM, Prideaux B, Lyon ER et al (2016)
Bedaquiline and pyrazinamide treatment
responses are affected by pulmonary lesion heterogeneity in Mycobacterium tuberculosis
infected C3HeB/FeJ mice. ACS Infect Dis
2:251–267
33. Carroll P, Schreuder LJ, Muwanguzi-Karugaba
J et al (2010) Sensitive detection of gene
expression in mycobacteria under replicating
and non-replicating conditions using optimized far-red reporters. PLoS One 5:e9823
34. Schreuder LJ, Carroll P, Muwanguzi-Karugaba
J et al (2015) Mycobacterium tuberculosis
H37Rv has a single nucleotide polymorphism
in PhoR which affects cell wall hydrophobicity
and
gene
expression.
Microbiology
161:765–773
35. Shell SS, Wang J, Lapierre P et al (2015) Leaderless transcripts and small proteins are common features of the mycobacterial translational
landscape. PLoS Genet 11:e1005641
36. Cronan MR, Rosenberg AF, Oehlers SH et al
(2015) CLARITY and PACT-based imaging of
adult zebrafish and mouse for whole-animal
analysis of infections. Dis Models Mech
8:1643–1650
Exploiting Fluorescent Reporter M. tuberculosis Strains
383
organization and replisome dynamics in Mycobacterium smegmatis. mBio 6:e01999–e01914
17. Wells RM, Jones CM, Xi Z et al (2013) Discovery of a siderophore export system essential
for virulence of Mycobacterium tuberculosis.
PLoS Pathog 9:e1003120
18. Jones CM, Niederweis M (2010) Role of porins in iron uptake by Mycobacterium smegmatis.
J Bacteriol 192:6411–6417
19. MacGilvary NJ, Kevorkian YL, Tan S (2019)
Potassium response and homeostasis in Mycobacterium tuberculosis modulate environmental
adaptation and is important for host colonization. PLoS Pathog 15:e1007591
20. Abramovitch RB, Rohde KH, Hsu FF et al
(2011) aprABC: a Mycobacterium tuberculosis
complex-specific
locus
that
modulates
pH-driven adaptation to the macrophage phagosome. Mol Microbiol l80:678–694
21. Bhaskar A, Chawla M, Mehta M et al (2014)
Reengineering redox sensitive GFP to measure
mycothiol redox potential of Mycobacterium
tuberculosis during infection. PLoS Pathog 10:
e1003902
22. Vandal OH, Pierini LM, Schnappinger D et al
(2008) A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nat Med 14:849–854
23. Huang L, Nazarova EV, Tan S et al (2018)
Growth of Mycobacterium tuberculosis in vivo
segregates with host macrophage metabolism
and ontogeny. J Exp Med 215:1135–1152
24. Zheng H, Colvin CJ, Johnson BK et al (2017)
Inhibitors of Mycobacterium tuberculosis
DosRST signaling and persistence. Nat Chem
Bio l13:218–225
25. Johnson BK, Colvin CJ, Needle DB et al
(2015) The carbonic anhydrase inhibitor
ethoxzolamide inhibits the Mycobacterium
tuberculosis PhoPR regulon and Esx-1 secretion and attenuates virulence. Antimicrob
Agents Chemother 59:4436–4445
26. Liu Y, Tan S, Huang L et al (2016) Immune
activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both
in vitro and in vivo. J Exp Med 213:809–825
27. Lenaerts A, Barry CE 3rd, Dartois V (2015)
Heterogeneity in tuberculosis pathology,
microenvironments and therapeutic responses.
Immunol Rev 264:288–307
28. Lin PL, Ford CB, Coleman MT et al (2014)
Sterilization of granulomas is common in active
and latent tuberculosis despite within-host
variability in bacterial killing. Nat Med
20:75–79
29. Cadena AM, Fortune SM, Flynn JL (2017)
Heterogeneity in tuberculosis. Nat Rev Immunol 17:691–702
30. Manina G, Dhar N, McKinney JD (2015)
Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity
and induce nongrowing metabolically active
forms. Cell Host Microbe 17:32–46
31. Marakalala MJ, Martinez FO, Pluddemann A
et al (2018) Macrophage heterogeneity in the
immunopathogenesis of tuberculosis. Front
Microbiol 9:1028
32. Irwin SM, Prideaux B, Lyon ER et al (2016)
Bedaquiline and pyrazinamide treatment
responses are affected by pulmonary lesion heterogeneity in Mycobacterium tuberculosis
infected C3HeB/FeJ mice. ACS Infect Dis
2:251–267
33. Carroll P, Schreuder LJ, Muwanguzi-Karugaba
J et al (2010) Sensitive detection of gene
expression in mycobacteria under replicating
and non-replicating conditions using optimized far-red reporters. PLoS One 5:e9823
34. Schreuder LJ, Carroll P, Muwanguzi-Karugaba
J et al (2015) Mycobacterium tuberculosis
H37Rv has a single nucleotide polymorphism
in PhoR which affects cell wall hydrophobicity
and
gene
expression.
Microbiology
161:765–773
35. Shell SS, Wang J, Lapierre P et al (2015) Leaderless transcripts and small proteins are common features of the mycobacterial translational
landscape. PLoS Genet 11:e1005641
36. Cronan MR, Rosenberg AF, Oehlers SH et al
(2015) CLARITY and PACT-based imaging of
adult zebrafish and mouse for whole-animal
analysis of infections. Dis Models Mech
8:1643–1650
Exploiting Fluorescent Reporter M. tuberculosis Strains
383