Figure 9.3
186
Bacterial Cellulose
for. Testing. and. Materials. (ASTM). International,. Subcommittee. F04.42. and.
have.been.published.as.a.“Guide.for.Characterization.of.Hydrogels.Used.in.
Regenerative.Medicine”.(Industry.Codes.2011).
Medical Implants from BNC
Its. specific. structure. and. properties. render. BNC. highly. suitable. as. a. biomaterial. for. a. wide. spectrum. of. medical. implants,. comprising. fleeces. and.
films.for.inlays,.patches.and.hollow.cylinders.for.cardiovascular.and.other.
tubular.grafts,.and.complex.shapes.for.the.replacement.of.complicated.3D.
organ.structures..In.the.following.two.sections,.examples.are.described.for.
the. development. of. flat. BNC. implants. for. joint. cartilage. repair,. and. tubular.BNC.materials.for.application.as.a.blood.vessel.substitute..The.examples.
include.current.work.ranging.from.initial.in.vitro.experiments.to.preclinical.
studies.in.large.animals.
BNC as an implant Material for the regeneration of Chondral Defects
The. specific. properties. of. BNC. discussed. previously. make. this. special. cellulose.hydrogel.a.promising.candidate.for.the.regeneration.of.joint.cartilage..
The. nanofiber. network. of. BNC. can. be. colonized. by. cartilage. cells. without.
problems..Figure 9.3.shows.cartilage.cells.on.a.BNC.implant..The.focus.of.the.
last.few.years.has.been.to.develop.bioactive.biomaterials.for.the.repair.and.
Figure 9.3
Scanning.electron.micrograph.of.human.chondrocytes.on.the.surface.of.BNC.after.24.h.cell.
seeding..(Scale.bar.=.10.μm.)
186
Bacterial Cellulose
for. Testing. and. Materials. (ASTM). International,. Subcommittee. F04.42. and.
have.been.published.as.a.“Guide.for.Characterization.of.Hydrogels.Used.in.
Regenerative.Medicine”.(Industry.Codes.2011).
Medical Implants from BNC
Its. specific. structure. and. properties. render. BNC. highly. suitable. as. a. biomaterial. for. a. wide. spectrum. of. medical. implants,. comprising. fleeces. and.
films.for.inlays,.patches.and.hollow.cylinders.for.cardiovascular.and.other.
tubular.grafts,.and.complex.shapes.for.the.replacement.of.complicated.3D.
organ.structures..In.the.following.two.sections,.examples.are.described.for.
the. development. of. flat. BNC. implants. for. joint. cartilage. repair,. and. tubular.BNC.materials.for.application.as.a.blood.vessel.substitute..The.examples.
include.current.work.ranging.from.initial.in.vitro.experiments.to.preclinical.
studies.in.large.animals.
BNC as an implant Material for the regeneration of Chondral Defects
The. specific. properties. of. BNC. discussed. previously. make. this. special. cellulose.hydrogel.a.promising.candidate.for.the.regeneration.of.joint.cartilage..
The. nanofiber. network. of. BNC. can. be. colonized. by. cartilage. cells. without.
problems..Figure 9.3.shows.cartilage.cells.on.a.BNC.implant..The.focus.of.the.
last.few.years.has.been.to.develop.bioactive.biomaterials.for.the.repair.and.
Figure 9.3
Scanning.electron.micrograph.of.human.chondrocytes.on.the.surface.of.BNC.after.24.h.cell.
seeding..(Scale.bar.=.10.μm.)