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Wnt Signaling in Tissue Differentiation
FIGURE 6.1 Nuclear localization of β-Catenin protein in dorsal blastomeres. Embryology, cell biology, and molecular biology come
together in this image of β-Catenin localization in Xenopus laevis blastula (Schneider et al., 1996). (A) view of the prospective ventral
side of blastula (stage 8.5 embryo). (B) view of the prospective dorsal side of the same blastula-stage embryo. Note that β -Catenin localization traces the outlines of the blastomere cells (in A and B, through its molecular association with adherence junctions); additionally,
but only on the prospective dorsal side (B), β-Catenin also localizes to cell nuclei. Detection of nuclear β-Catenin is now established as
the hallmark of activated canonical Wnt signaling.
Source: Images reproduced with permission from Elsevier publishers [Copyright Clearance Center (RightsLink) License Number 4961291291588)].
FIGURE 6.2 Different Wnt signaling pathways as discussed in the text. Left: Canonical, Wnt/b-catenin signaling. Middle: Noncanonical, Wnt/PCP signaling. Right: Non-canonical, Wnt/Ca signaling. Dashed lines indicate selected cross talks of Wnt signaling
with other pathways.
Wnt Signaling in Tissue Differentiation
FIGURE 6.1 Nuclear localization of β-Catenin protein in dorsal blastomeres. Embryology, cell biology, and molecular biology come
together in this image of β-Catenin localization in Xenopus laevis blastula (Schneider et al., 1996). (A) view of the prospective ventral
side of blastula (stage 8.5 embryo). (B) view of the prospective dorsal side of the same blastula-stage embryo. Note that β -Catenin localization traces the outlines of the blastomere cells (in A and B, through its molecular association with adherence junctions); additionally,
but only on the prospective dorsal side (B), β-Catenin also localizes to cell nuclei. Detection of nuclear β-Catenin is now established as
the hallmark of activated canonical Wnt signaling.
Source: Images reproduced with permission from Elsevier publishers [Copyright Clearance Center (RightsLink) License Number 4961291291588)].
FIGURE 6.2 Different Wnt signaling pathways as discussed in the text. Left: Canonical, Wnt/b-catenin signaling. Middle: Noncanonical, Wnt/PCP signaling. Right: Non-canonical, Wnt/Ca signaling. Dashed lines indicate selected cross talks of Wnt signaling
with other pathways.