Index
347
genome sequencing, 158
half embryos, self-organizing properties, 48
homeologous chromosomes, designation,
158
model organism, usage, 290–291
natural size polymorphism, relationship, 318
nuclear reprogramming process, molecular
insights, 329–332
pkd1 (CRISPR knockout), 215
subgenomes, gene organization (details),
163, 165
Xenopus laevis (XLA) embryos
developmental stages, workf ow schematic,
201
images, 261
research, 48
Xenopus laevis (XLA) genomes
assembly, 157–158
notch signaling responsiveness, 82
sequencing, 44, 157–158
Xenopus laevis (XLA)/Xenopus tropicalis
chromosomal relationships, 160–161
comparison, 158
contrast, 200–201
Xenopus notch pathway
components, 81
hes1-7/hey genes, responsiveness
(experimental evidence), 83–87
Xenopus oocytes
endogenous ion channels, usage, 145–146
usage, 143–144
vegetal pole mRNAs, cell-free translation, 26
Xenopus oocytes, usage, 143
past observations, 143–144
present status, 144–147
Xenopus tadpole
immunostaining, usage, 5
Smit illustration, 5
Xenopus tropicalis (XTR)
biomedical research usage, 315
cancer modeling methodologies, 307–308
cancer models, applications, 306
chromosomes, 164
CRISPR/Cas9 cancer modeling, 305
development, chromatin state maps
(genome browser view), 175
F 0 X. tropicalis tumor, crispants (presence),
304
forward genetic screens, usage, 210–211
genetic research, diploid genome (impact), 302
genome sequencing, 157
hes1-7/hey groups genes, notch signaling
responsiveness, 82
Xenopus laevis, chromosomal relationships,
160–161
Xenopus laevis, comparison, 158
Xenopus laevis, contrast, 200–201
Xic1, modif cation, 19
XLA2Lq32-33, W-specif c/Z-specifc regions, 162
XLA3L, 165
XLA9_10, chromosome fusion sites
(identif cation), 158
Xvent1/2, function, 45
Y
Yamada, Tsuneo, 8
Yamanaka, Shinya, 325
YAP (Hippo signaling pathway component), 71
Yong, Ed, 6
Z
Zebraf sh (Danio rerio)
biomedical research usage, 315
DNA methylation, oocyte/sperm patterns
(differences), 181
larvae/immunocompromised adults,
xenotransplantation recipient usage,
307–308
SCI response, 295
Zebrafsh, histone modifcation dynamics, 179
Zebrafish International Resource Center
(ZIRC), donor vector procurement,
208
Zinc Finger Nucleases (ZFNs), usage, 212,
301
Z-specifc regions, 161, 162
Zwarenstein, Harry, 7
Zwischenstrang, 126
Zygotic genome activation (ZGA), 187
maternal Wnt signaling, relationship, 70
onset, chromatin assembly (relationship),
177
Zygotic transcription factors, identif cation, 30
Zygotic Wnt8/beta-catenin, action, 265
347
genome sequencing, 158
half embryos, self-organizing properties, 48
homeologous chromosomes, designation,
158
model organism, usage, 290–291
natural size polymorphism, relationship, 318
nuclear reprogramming process, molecular
insights, 329–332
pkd1 (CRISPR knockout), 215
subgenomes, gene organization (details),
163, 165
Xenopus laevis (XLA) embryos
developmental stages, workf ow schematic,
201
images, 261
research, 48
Xenopus laevis (XLA) genomes
assembly, 157–158
notch signaling responsiveness, 82
sequencing, 44, 157–158
Xenopus laevis (XLA)/Xenopus tropicalis
chromosomal relationships, 160–161
comparison, 158
contrast, 200–201
Xenopus notch pathway
components, 81
hes1-7/hey genes, responsiveness
(experimental evidence), 83–87
Xenopus oocytes
endogenous ion channels, usage, 145–146
usage, 143–144
vegetal pole mRNAs, cell-free translation, 26
Xenopus oocytes, usage, 143
past observations, 143–144
present status, 144–147
Xenopus tadpole
immunostaining, usage, 5
Smit illustration, 5
Xenopus tropicalis (XTR)
biomedical research usage, 315
cancer modeling methodologies, 307–308
cancer models, applications, 306
chromosomes, 164
CRISPR/Cas9 cancer modeling, 305
development, chromatin state maps
(genome browser view), 175
F 0 X. tropicalis tumor, crispants (presence),
304
forward genetic screens, usage, 210–211
genetic research, diploid genome (impact), 302
genome sequencing, 157
hes1-7/hey groups genes, notch signaling
responsiveness, 82
Xenopus laevis, chromosomal relationships,
160–161
Xenopus laevis, comparison, 158
Xenopus laevis, contrast, 200–201
Xic1, modif cation, 19
XLA2Lq32-33, W-specif c/Z-specifc regions, 162
XLA3L, 165
XLA9_10, chromosome fusion sites
(identif cation), 158
Xvent1/2, function, 45
Y
Yamada, Tsuneo, 8
Yamanaka, Shinya, 325
YAP (Hippo signaling pathway component), 71
Yong, Ed, 6
Z
Zebraf sh (Danio rerio)
biomedical research usage, 315
DNA methylation, oocyte/sperm patterns
(differences), 181
larvae/immunocompromised adults,
xenotransplantation recipient usage,
307–308
SCI response, 295
Zebrafsh, histone modifcation dynamics, 179
Zebrafish International Resource Center
(ZIRC), donor vector procurement,
208
Zinc Finger Nucleases (ZFNs), usage, 212,
301
Z-specifc regions, 161, 162
Zwarenstein, Harry, 7
Zwischenstrang, 126
Zygotic genome activation (ZGA), 187
maternal Wnt signaling, relationship, 70
onset, chromatin assembly (relationship),
177
Zygotic transcription factors, identif cation, 30
Zygotic Wnt8/beta-catenin, action, 265