334
Xenopus
Halley-Stott, R. P., Pasque, V., Astrand, C., Miyamoto, K., Simeoni,
I., Jullien, J., & Gurdon, J. B. (2010). Mammalian nuclear
transplantation to germinal vesicle stage Xenopus oocytes:
A method for quantitative transcriptional reprogramming.
Methods (San Diego, Calif.), 51(1), 56–65. https://doi.
org/10.1016/j.ymeth.2010.01.035
Hansis, C., Barreto, G., Maltry, N., & Niehrs, C. (2004). Nuclear
reprogramming of human somatic cells by Xenopus egg
extract requires BRG1. Current Biology, 14 (16), 1475–1480.
https://doi.org/10.1016/j.cub.2004.08.031
Hörmanseder, E., Simeone, A., Allen, G. E., Bradshaw, C. R.,
Figlmüller, M., Gurdon, J., & Jullien, J. (2017). H3K4
methylation-dependent memory of somatic cell identity
inhibits reprogramming and development of nuclear transfer embryos. Cell Stem Cell, 21(1), 135–143.e6. https://doi.
org/10.1016/j.stem.2017.03.003
Jullien, J., Astrand, C., Halley-Stott, R. P., Garrett, N., & Gurdon,
J. B. (2010). Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for
pluripotency gene reactivation. Proceedings of the National
Academy of Sciences of the United States of America, 107(12),
5483–5488. https://doi.org/10.1073/pnas.1000599107
Jullien, J., Astrand, C., Szenker, E., Garrett, N., Almouzni, G., &
Gurdon, J. B. (2012). HIRA dependent H3.3 deposition is
required for transcriptional reprogramming following nuclear
transfer to Xenopus oocytes. Epigenetics & Chromatin, 5(1),
17. https://doi.org/10.1186/1756-8935-5-17
Jullien, J., Miyamoto, K., Pasque, V., Allen, G. E., Bradshaw, C.
R., Garrett, N. J., Halley-Stott, R. P., Kimura, H., Ohsumi,
K., & Gurdon, J. B. (2014). Hierarchical molecular events
driven by oocyte-specifc factors lead to rapid and extensive
reprogramming. Molecular Cell, 55(4), 524–536. https://doi.
org/10.1016/j.molcel.2014.06.024
Jullien, J., Vodnala, M., Pasque, V., Oikawa, M., Miyamoto, K.,
Allen, G., David, S. A., Brochard, V., Wang, S., Bradshaw,
C., Koseki, H., Sartorelli, V., Beaujean, N., & Gurdon, J.
(2017). Gene resistance to transcriptional reprogramming
following nuclear transfer is directly mediated by multiple
chromatin-repressive pathways. Molecular Cell, 65 (5), 873–
884.e8. https://doi.org/10.1016/j.molcel.2017.01.030
Kang, Y.-K., Koo, D.-B., Park, J.-S., Choi, Y.-H., Chung, A.-S.,
Lee, K.-K., & Han, Y.-M. (2001). Aberrant methylation of
donor genome in cloned bovine embryos. Nature Genetics,
28 (2), 173–177. https://doi.org/10.1038/88903
King, T. J., & Briggs, R. (1956). Serial transplantation of
embryonic nuclei. Cold Spring Harbor Symposia on
Quantitative Biology, 21, 271–290. https://doi.org/10.1101/
sqb.1956.021.01.022
Kouzarides, T. (2007). Chromatin modifcations and their
function. Cell, 128(4), 693–705. https://doi.org/10.1016/j.
cell.2007.02.005
Laskey, R. A., & Gurdon, J. B. (1970). Genetic content of adult
somatic cells tested by nuclear transplantation from cultured cells. Nature, 228(5278), 1332–1334. https://doi.
org/10.1038/2281332a0
Lemaitre, J. M., Danis, E., Pasero, P., Vassetzky, Y., & Méchali, M.
(2005). Mitotic remodeling of the replicon and chromosome
structure. Cell, 123(5), 787–801. https://doi.org/10.1016/j.
cell.2005.08.045
Lister, R., Pelizzola, M., Kida, Y. S., Hawkins, R. D., Nery, J. R.,
Hon, G., Antosiewicz-Bourget, J., O’Malley, R., Castanon,
R., Klugman, S., Downes, M., Yu, R., Stewart, R., Ren,
B., Thomson, J. A., Evans, R. M., & Ecker, J. R. (2011).
Hotspots of aberrant epigenomic reprogramming in human
induced pluripotent stem cells. Nature, 471(7336), 68–73.
https://doi.org/10.1038/nature09798
Liu, W., Liu, X., Wang, C., Gao, Y., Gao, R., Kou, X., Zhao, Y.,
Li, J., Wu, Y., Xiu, W., Wang, S., Yin, J., Liu, W., Cai, T.,
Wang, H., Zhang, Y., & Gao, S. (2016). Identif cation of
key factors conquering developmental arrest of somatic cell
cloned embryos by combining embryo biopsy and singlecell sequencing. Cell Discovery, 2(1), 1–15. https://doi.
org/10.1038/celldisc.2016.10
Liu, Z., Cai, Y., Wang, Y., Nie, Y., Zhang, C., Xu, Y., Zhang, X., Lu,
Y., Wang, Z., Poo, M., & Sun, Q. (2018). Cloning of macaque
monkeys by somatic cell nuclear transfer. Cell, 172 (4), 881–
887.e7. https://doi.org/10.1016/j.cell.2018.01.020
Lohka, M. J., & Masui, Y. (1983). Formation in vitro of sperm
pronuclei and mitotic chromosomes induced by amphibian ooplasmic components. Science, 220(4598), 719–721.
https://doi.org/10.1126/science.6601299
Matoba, S., Liu, Y., Lu, F., Iwabuchi, K. A., Shen, L., Inoue, A., &
Zhang, Y. (2014). Embryonic development following somatic
cell nuclear transfer impeded by persisting histone methylation.
Cell, 159 (4), 884–895. https://doi.org/10.1016/j.cell.2014.09.055
Matoba, S., & Zhang, Y. (2018). Somatic cell nuclear transfer reprogramming: Mechanisms and applications. Cell Stem Cell,
23 (4), 471–485. https://doi.org/10.1016/j.stem.2018.06.018
Mikkelsen, T. S., Hanna, J., Zhang, X., Ku, M., Wernig, M.,
Schorderet, P., Bernstein, B. E., Jaenisch, R., Lander, E. S.,
& Meissner, A. (2008). Dissecting direct reprogramming
through integrative genomic analysis. Nature, 454(7200),
49–55. https://doi.org/10.1038/nature07056
Miyamoto, K., Pasque, V., Jullien, J., & Gurdon, J. B. (2011).
Nuclear actin polymerization is required for transcriptional
reprogramming of Oct4 by oocytes. Genes & Development,
25 (9), 946–958. https://doi.org/10.1101/gad.615211
Miyamoto, K., Teperek, M., Yusa, K., Allen, G. E., Bradshaw,
C. R., & Gurdon, J. B. (2013). Nuclear wave1 is required
for reprogramming transcription in oocytes and for normal
development. Science (New York, N.Y.), 341(6149), 1002–
1005. https://doi.org/10.1126/science.1240376
Miyamoto, K., Tsukiyama, T., Yang, Y., Li, N., Minami, N.,
Yamada, M., & Imai, H. (2009). Cell-free extracts from
mammalian oocytes partially induce nuclear reprogramming
in somatic cells. Biology of Reproduction, 80(5), 935–943.
https://doi.org/10.1095/biolreprod.108.073676
Ng, R. K., & Gurdon, J. B. (2005). Epigenetic memory of active
gene transcription is inherited through somatic cell nuclear
transfer. Proceedings of the National Academy of Sciences of
the United States of America, 102(6), 1957–1962. https://doi.
org/10.1073/pnas.0409813102
Ng, R. K., & Gurdon, J. B. (2008). Epigenetic memory of an active
gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription. Nature Cell Biology,
10 (1), 102–109. https://doi.org/10.1038/ncb1674
Pasque, V., Gillich, A., Garrett, N., & Gurdon, J. B. (2011). Histone
variant macroH2A confers resistance to nuclear reprogramming. The EMBO Journal, 30(12), 2373–2387. https://doi.
org/10.1038/emboj.2011.144
Pasque, V., Radzisheuskaya, A., Gillich, A., Halley-Stott, R. P.,
Panamarova, M., Zernicka-Goetz, M., Surani, M. A., &
Silva, J. C. (2012). Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier
to induced pluripotency. Journal of Cell Science, 125 (Pt 24),
6094–6104. https://doi.org/10.1242/jcs.113019
Polejaeva, I. A., Chen, S. H., Vaught, T. D., Page, R. L., Mullins, J.,
Ball, S., Dai, Y., Boone, J., Walker, S., Ayares, D. L., Colman,
Xenopus
Halley-Stott, R. P., Pasque, V., Astrand, C., Miyamoto, K., Simeoni,
I., Jullien, J., & Gurdon, J. B. (2010). Mammalian nuclear
transplantation to germinal vesicle stage Xenopus oocytes:
A method for quantitative transcriptional reprogramming.
Methods (San Diego, Calif.), 51(1), 56–65. https://doi.
org/10.1016/j.ymeth.2010.01.035
Hansis, C., Barreto, G., Maltry, N., & Niehrs, C. (2004). Nuclear
reprogramming of human somatic cells by Xenopus egg
extract requires BRG1. Current Biology, 14 (16), 1475–1480.
https://doi.org/10.1016/j.cub.2004.08.031
Hörmanseder, E., Simeone, A., Allen, G. E., Bradshaw, C. R.,
Figlmüller, M., Gurdon, J., & Jullien, J. (2017). H3K4
methylation-dependent memory of somatic cell identity
inhibits reprogramming and development of nuclear transfer embryos. Cell Stem Cell, 21(1), 135–143.e6. https://doi.
org/10.1016/j.stem.2017.03.003
Jullien, J., Astrand, C., Halley-Stott, R. P., Garrett, N., & Gurdon,
J. B. (2010). Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for
pluripotency gene reactivation. Proceedings of the National
Academy of Sciences of the United States of America, 107(12),
5483–5488. https://doi.org/10.1073/pnas.1000599107
Jullien, J., Astrand, C., Szenker, E., Garrett, N., Almouzni, G., &
Gurdon, J. B. (2012). HIRA dependent H3.3 deposition is
required for transcriptional reprogramming following nuclear
transfer to Xenopus oocytes. Epigenetics & Chromatin, 5(1),
17. https://doi.org/10.1186/1756-8935-5-17
Jullien, J., Miyamoto, K., Pasque, V., Allen, G. E., Bradshaw, C.
R., Garrett, N. J., Halley-Stott, R. P., Kimura, H., Ohsumi,
K., & Gurdon, J. B. (2014). Hierarchical molecular events
driven by oocyte-specifc factors lead to rapid and extensive
reprogramming. Molecular Cell, 55(4), 524–536. https://doi.
org/10.1016/j.molcel.2014.06.024
Jullien, J., Vodnala, M., Pasque, V., Oikawa, M., Miyamoto, K.,
Allen, G., David, S. A., Brochard, V., Wang, S., Bradshaw,
C., Koseki, H., Sartorelli, V., Beaujean, N., & Gurdon, J.
(2017). Gene resistance to transcriptional reprogramming
following nuclear transfer is directly mediated by multiple
chromatin-repressive pathways. Molecular Cell, 65 (5), 873–
884.e8. https://doi.org/10.1016/j.molcel.2017.01.030
Kang, Y.-K., Koo, D.-B., Park, J.-S., Choi, Y.-H., Chung, A.-S.,
Lee, K.-K., & Han, Y.-M. (2001). Aberrant methylation of
donor genome in cloned bovine embryos. Nature Genetics,
28 (2), 173–177. https://doi.org/10.1038/88903
King, T. J., & Briggs, R. (1956). Serial transplantation of
embryonic nuclei. Cold Spring Harbor Symposia on
Quantitative Biology, 21, 271–290. https://doi.org/10.1101/
sqb.1956.021.01.022
Kouzarides, T. (2007). Chromatin modifcations and their
function. Cell, 128(4), 693–705. https://doi.org/10.1016/j.
cell.2007.02.005
Laskey, R. A., & Gurdon, J. B. (1970). Genetic content of adult
somatic cells tested by nuclear transplantation from cultured cells. Nature, 228(5278), 1332–1334. https://doi.
org/10.1038/2281332a0
Lemaitre, J. M., Danis, E., Pasero, P., Vassetzky, Y., & Méchali, M.
(2005). Mitotic remodeling of the replicon and chromosome
structure. Cell, 123(5), 787–801. https://doi.org/10.1016/j.
cell.2005.08.045
Lister, R., Pelizzola, M., Kida, Y. S., Hawkins, R. D., Nery, J. R.,
Hon, G., Antosiewicz-Bourget, J., O’Malley, R., Castanon,
R., Klugman, S., Downes, M., Yu, R., Stewart, R., Ren,
B., Thomson, J. A., Evans, R. M., & Ecker, J. R. (2011).
Hotspots of aberrant epigenomic reprogramming in human
induced pluripotent stem cells. Nature, 471(7336), 68–73.
https://doi.org/10.1038/nature09798
Liu, W., Liu, X., Wang, C., Gao, Y., Gao, R., Kou, X., Zhao, Y.,
Li, J., Wu, Y., Xiu, W., Wang, S., Yin, J., Liu, W., Cai, T.,
Wang, H., Zhang, Y., & Gao, S. (2016). Identif cation of
key factors conquering developmental arrest of somatic cell
cloned embryos by combining embryo biopsy and singlecell sequencing. Cell Discovery, 2(1), 1–15. https://doi.
org/10.1038/celldisc.2016.10
Liu, Z., Cai, Y., Wang, Y., Nie, Y., Zhang, C., Xu, Y., Zhang, X., Lu,
Y., Wang, Z., Poo, M., & Sun, Q. (2018). Cloning of macaque
monkeys by somatic cell nuclear transfer. Cell, 172 (4), 881–
887.e7. https://doi.org/10.1016/j.cell.2018.01.020
Lohka, M. J., & Masui, Y. (1983). Formation in vitro of sperm
pronuclei and mitotic chromosomes induced by amphibian ooplasmic components. Science, 220(4598), 719–721.
https://doi.org/10.1126/science.6601299
Matoba, S., Liu, Y., Lu, F., Iwabuchi, K. A., Shen, L., Inoue, A., &
Zhang, Y. (2014). Embryonic development following somatic
cell nuclear transfer impeded by persisting histone methylation.
Cell, 159 (4), 884–895. https://doi.org/10.1016/j.cell.2014.09.055
Matoba, S., & Zhang, Y. (2018). Somatic cell nuclear transfer reprogramming: Mechanisms and applications. Cell Stem Cell,
23 (4), 471–485. https://doi.org/10.1016/j.stem.2018.06.018
Mikkelsen, T. S., Hanna, J., Zhang, X., Ku, M., Wernig, M.,
Schorderet, P., Bernstein, B. E., Jaenisch, R., Lander, E. S.,
& Meissner, A. (2008). Dissecting direct reprogramming
through integrative genomic analysis. Nature, 454(7200),
49–55. https://doi.org/10.1038/nature07056
Miyamoto, K., Pasque, V., Jullien, J., & Gurdon, J. B. (2011).
Nuclear actin polymerization is required for transcriptional
reprogramming of Oct4 by oocytes. Genes & Development,
25 (9), 946–958. https://doi.org/10.1101/gad.615211
Miyamoto, K., Teperek, M., Yusa, K., Allen, G. E., Bradshaw,
C. R., & Gurdon, J. B. (2013). Nuclear wave1 is required
for reprogramming transcription in oocytes and for normal
development. Science (New York, N.Y.), 341(6149), 1002–
1005. https://doi.org/10.1126/science.1240376
Miyamoto, K., Tsukiyama, T., Yang, Y., Li, N., Minami, N.,
Yamada, M., & Imai, H. (2009). Cell-free extracts from
mammalian oocytes partially induce nuclear reprogramming
in somatic cells. Biology of Reproduction, 80(5), 935–943.
https://doi.org/10.1095/biolreprod.108.073676
Ng, R. K., & Gurdon, J. B. (2005). Epigenetic memory of active
gene transcription is inherited through somatic cell nuclear
transfer. Proceedings of the National Academy of Sciences of
the United States of America, 102(6), 1957–1962. https://doi.
org/10.1073/pnas.0409813102
Ng, R. K., & Gurdon, J. B. (2008). Epigenetic memory of an active
gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription. Nature Cell Biology,
10 (1), 102–109. https://doi.org/10.1038/ncb1674
Pasque, V., Gillich, A., Garrett, N., & Gurdon, J. B. (2011). Histone
variant macroH2A confers resistance to nuclear reprogramming. The EMBO Journal, 30(12), 2373–2387. https://doi.
org/10.1038/emboj.2011.144
Pasque, V., Radzisheuskaya, A., Gillich, A., Halley-Stott, R. P.,
Panamarova, M., Zernicka-Goetz, M., Surani, M. A., &
Silva, J. C. (2012). Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier
to induced pluripotency. Journal of Cell Science, 125 (Pt 24),
6094–6104. https://doi.org/10.1242/jcs.113019
Polejaeva, I. A., Chen, S. H., Vaught, T. D., Page, R. L., Mullins, J.,
Ball, S., Dai, Y., Boone, J., Walker, S., Ayares, D. L., Colman,