242
Xenopus
Cell Cycle 12 (24): 3804–3816. https://doi.org/10.4161/
cc.26671 .
Homsy, Jason, Samir Zaidi, Yufeng Shen, James S. Ware, Kaitlin
E. Samocha, Konrad J. Karczewski, Steven R. Depalma,
et al. 2015. “De Novo Mutations in Congenital Heart Disease
with Neurodevelopmental and Other Congenital Anomalies.”
Science 350 (6265): 1262–1266. https://doi.org/10.1126/
science.aac9396 .
Horb, Marko E., and Gerald H. Thomsen. 1999. “Tbx5 Is Essential
for Heart Development.” Development 126 (8): 1739–1751.
Itoh, Go, Shiro Sugino, Masanori Ikeda, Mayumi Mizuguchi, Shin
Ichiro Kanno, Mohammed A. Amin, Kenji Iemura, Akira
Yasui, Toru Hirota, and Kozo Tanaka. 2013. “Nucleoporin
Nup188 Is Required for Chromosome Alignment in Mitosis.”
Cancer Science 104 (7): 871–879. https://doi.org/10.1111/
cas.12159 .
Jin, Sheng Chih, Jason Homsy, Samir Zaidi, Qiongshi Lu,
Sarah Morton, Steven R. Depalma, Xue Zeng, et al. 2017.
“Contribution of Rare Inherited and De Novo Variants in
2,871 Congenital Heart Disease Probands.” Nature Genetics
49 (11): 1593–1601. https://doi.org/10.1038/ng.3970 .
Kee, Hooi Lynn, John F. Dishinger, T. Lynne Blasius, Chia Jen Liu,
Ben Margolis, and Kristen J. Verhey. 2012. “A Size-Exclusion
Permeability Barrier and Nucleoporins Characterize a Ciliary
Pore Complex That Regulates Transport into Cilia.” Nature
Cell Biology 14 (4): 431–437. https://doi.org/10.1038/
ncb2450 .
Kelley, C., H. Blumberg, L. I. Zon, and T. Evans. 1993. “GATA-4
Is a Novel Transcription Factor Expressed in Endocardium
of the Developing Heart.” Development 118 (3): 817–827.
Kioussi, Chrissa, Paola Briata, Sung Hee Baek, David W. Rose,
Natasha S. Hamblet, Thomas Herman, Kenneth A. Ohgi,
et al. 2002. “Identifcation of a Wnt/Dvl/β-Catenin →
Pitx2 Pathway Mediating Cell-Type-Specif c Proliferation
during Development.” Cell 111 (5): 673–685. https://doi.
org/10.1016/S0092-8674(02)01084-X .
Kirk, Edwin P., Margaret Sunde, Mauro W. Costa, Scott A.
Rankin, Orit Wolstein, M. Leticia Castro, Tanya L. Butler,
et al. 2007. “Mutations in Crdiac T-Box Factor Gene
TBX20 Are Associated with Diverse Cardiac Pathologies,
Including Defects of Septation and Valvulogenesis and
Cardiomyopathy.” American Journal of Human Genetics 81
(2): 280–291. https://doi.org/10.1086/519530 .
Krebs, Luke T., Naomi Iwai, Shigenori Nonaka, Ian C. Welsh,
Yu Lan, Rulang Jiang, Yukio Saijoh, Timothy P. O’Brien,
Hiroshi Hamada, and Thomas Gridley. 2003. “Notch
Signaling Regulates Left-Right Asymmetry Determination
by Inducing Nodal Expression.” Genes & Development 17
(10): 1207–1212. https://doi.org/10.1101/gad.1084703 .
Leprince, D., A. Gegonne, J. Coll, C. De Taisne, A. Schneeberger,
C. Lagrou, and D. Stehelin. 1983. “A Putative Second CellDerived Oncogene of the Avian Leukaemia Retrovirus
E26.” Nature 306 (5941): 395–397. https://doi.org/10.1038/
306395a0 .
Lin, Angela E., Sergey Krikov, Tiffany Riehle-Colarusso, Jaime
L. Frías, John Belmont, Marlene Anderka, Tal Geva, Kelly
D. Getz, and Lorenzo D. Botto. 2014. “Laterality Defects in
the National Birth Defects Prevention Study (1998–2007):
Birth Prevalence and Descriptive Epidemiology.” American
Journal of Medical Genetics, Part A 164 (10): 2581–2591.
https://doi.org/10.1002/ajmg.a.36695 .
Liu, Yan, Narendra Pathak, Albrecht Kramer-Zucker, and Iain
A. Drummond. 2007. “Notch Signaling Controls the
Differentiation of Transporting Epithelia and Multiciliated
Cells in the Zebrafsh Pronephros.” Development 134 (6):
1111–1122. https://doi.org/10.1242/dev.02806 .
Loïodice, Isabelle, Annabelle Alves, Gwénaël Rabut, Megan
van Overbeek, Jan Ellenberg, Jean-Baptiste Sibarita, and
Valérie Doye. 2004. “The Entire Nup107–160 Complex,
Including Three New Members, Is Targeted as One Entity to
Kinetochores in Mitosis.” Molecular Biology of the Cell 15
(7): 3333–3344. https://doi.org/10.1091/mbc.e03-12-0878 .
Ma, Ming, and Yun Jin Jiang. 2007. “Jagged2a-Notch Signaling
Mediates Cell Fate Choice in the Zebrafsh Pronephric Duct.”
PLoS Genetics 3 (1): 0133–145. https://doi.org/10.1371/
journal.pgen.0030018 .
Mai, Cara T., Jennifer L. Isenburg, Mark A. Canfeld, Robert E.
Meyer, Adolfo Correa, Clinton J. Alverson, Philip J. Lupo,
et al. 2019. “National Population-Based Estimates for Major
Birth Defects, 2010–2014.” Birth Defects Research 111 (18):
1420–1435. https://doi.org/10.1002/bdr2.1589 .
Maj, Ewa, Lutz Künneke, Elisabeth Loresch, Anita Grund,
Juliane Melchert, Tomas Pieler, Timo Aspelmeier, and
Annette Borchers. 2016. “Controlled Levels of Canonical
Wnt Signaling Are Required for Neural Crest Migration.”
Developmental Biology 417 (1): 77–90. https://doi.org/10.
1016/j.ydbio.2016.06.022 .
Marino, Bradley S., P. H. Lipkin, Jane W. Newburger, Georgina
Peacock, Marsha Gerdes, J. William Gaynor, Kathleen A.
Mussatto, et al. 2012. “Neurodevelopmental Outcomes in
Children with Congenital Heart Disease: Evaluation and
Management a Scientifc Statement from the American Heart
Association.” Circulation 126 (9): 1143–1172. https://doi.
org/10.1161/CIR.0b013e318265ee8a .
Marquez, Jonathan, June Criscione, Rebekah M. Charney,
Maneeshi S. Prasad, Woong Y. Hwang, Emily K. Mis, Martín
I. García-Castro, and Mustafa K. Khokha. 2020. “Disrupted
ER Membrane Protein Complex-Mediated Topogenesis
Drives Congenital Neural Crest Defects.” Journal of Clinical
Investigation 130 (2): 813–826. https://doi.org/10.1172/
JCI129308 .
Mcdermott, Deborah A., Michael C. Bressan, Jie He, Joseph S. Lee,
Salim Aftimos, Martina Brueckner, Fred Gilbert, et al. 2005.
“TBX5 Genetic Testing Validates Strict Clinical Criteria for
Holt-Oram Syndrome.” Pediatric Research 58 (5): 981–986.
https://doi.org/10.1203/01.PDR.0000182593.95441.64 .
McGrath, James, Stefan Somlo, Svetlana Makova, Xin Tian,
and Martina Brueckner. 2003. “Two Populations of Node
Monocilia Initiate Left-Right Asymmetry in the Mouse.”
Cell 114 (1): 61–73. https://doi.org/10.1016/S0092-8674
(03)00511-7 .
Meyer, D., M. Durliat, F. Senan, M. Wolff, M. Andre, J. Hourdry,
and P. Remy. 1997. “Ets-1 and Ets-2 Proto-Oncogenes
Exhibit Differential and Restricted Expression Patterns during Xenopus laevis Oogenesis and Embryogenesis.” Edited by
Derek Stemple. The International Journal of Developmental
Biology 41 (4): 607–620. https://doi.org/10.1371/journal.
pbio.0040010 .
Minegishi, Katsura, Masakazu Hashimoto, Rieko Ajima,
Katsuyoshi Takaoka, Kyosuke Shinohara, Yayoi Ikawa,
Hiromi Nishimura, et al. 2017. “A Wnt5 Activity Asymmetry
and Intercellular Signaling via PCP Proteins Polarize Node
Cells for Left-Right Symmetry Breaking.” Developmental
Cell 40 (5): 439–452.e4. https://doi.org/10.1016/j.devcel.
2017.02.010.
Mussatto, Kathleen A., Raymond G. Hoffmann, George M.
Hoffman, James S. Tweddell, Laurel Bear, Yumei Cao, and
Cheryl Brosig. 2014. “Risk and Prevalence of Developmental
Xenopus
Cell Cycle 12 (24): 3804–3816. https://doi.org/10.4161/
cc.26671 .
Homsy, Jason, Samir Zaidi, Yufeng Shen, James S. Ware, Kaitlin
E. Samocha, Konrad J. Karczewski, Steven R. Depalma,
et al. 2015. “De Novo Mutations in Congenital Heart Disease
with Neurodevelopmental and Other Congenital Anomalies.”
Science 350 (6265): 1262–1266. https://doi.org/10.1126/
science.aac9396 .
Horb, Marko E., and Gerald H. Thomsen. 1999. “Tbx5 Is Essential
for Heart Development.” Development 126 (8): 1739–1751.
Itoh, Go, Shiro Sugino, Masanori Ikeda, Mayumi Mizuguchi, Shin
Ichiro Kanno, Mohammed A. Amin, Kenji Iemura, Akira
Yasui, Toru Hirota, and Kozo Tanaka. 2013. “Nucleoporin
Nup188 Is Required for Chromosome Alignment in Mitosis.”
Cancer Science 104 (7): 871–879. https://doi.org/10.1111/
cas.12159 .
Jin, Sheng Chih, Jason Homsy, Samir Zaidi, Qiongshi Lu,
Sarah Morton, Steven R. Depalma, Xue Zeng, et al. 2017.
“Contribution of Rare Inherited and De Novo Variants in
2,871 Congenital Heart Disease Probands.” Nature Genetics
49 (11): 1593–1601. https://doi.org/10.1038/ng.3970 .
Kee, Hooi Lynn, John F. Dishinger, T. Lynne Blasius, Chia Jen Liu,
Ben Margolis, and Kristen J. Verhey. 2012. “A Size-Exclusion
Permeability Barrier and Nucleoporins Characterize a Ciliary
Pore Complex That Regulates Transport into Cilia.” Nature
Cell Biology 14 (4): 431–437. https://doi.org/10.1038/
ncb2450 .
Kelley, C., H. Blumberg, L. I. Zon, and T. Evans. 1993. “GATA-4
Is a Novel Transcription Factor Expressed in Endocardium
of the Developing Heart.” Development 118 (3): 817–827.
Kioussi, Chrissa, Paola Briata, Sung Hee Baek, David W. Rose,
Natasha S. Hamblet, Thomas Herman, Kenneth A. Ohgi,
et al. 2002. “Identifcation of a Wnt/Dvl/β-Catenin →
Pitx2 Pathway Mediating Cell-Type-Specif c Proliferation
during Development.” Cell 111 (5): 673–685. https://doi.
org/10.1016/S0092-8674(02)01084-X .
Kirk, Edwin P., Margaret Sunde, Mauro W. Costa, Scott A.
Rankin, Orit Wolstein, M. Leticia Castro, Tanya L. Butler,
et al. 2007. “Mutations in Crdiac T-Box Factor Gene
TBX20 Are Associated with Diverse Cardiac Pathologies,
Including Defects of Septation and Valvulogenesis and
Cardiomyopathy.” American Journal of Human Genetics 81
(2): 280–291. https://doi.org/10.1086/519530 .
Krebs, Luke T., Naomi Iwai, Shigenori Nonaka, Ian C. Welsh,
Yu Lan, Rulang Jiang, Yukio Saijoh, Timothy P. O’Brien,
Hiroshi Hamada, and Thomas Gridley. 2003. “Notch
Signaling Regulates Left-Right Asymmetry Determination
by Inducing Nodal Expression.” Genes & Development 17
(10): 1207–1212. https://doi.org/10.1101/gad.1084703 .
Leprince, D., A. Gegonne, J. Coll, C. De Taisne, A. Schneeberger,
C. Lagrou, and D. Stehelin. 1983. “A Putative Second CellDerived Oncogene of the Avian Leukaemia Retrovirus
E26.” Nature 306 (5941): 395–397. https://doi.org/10.1038/
306395a0 .
Lin, Angela E., Sergey Krikov, Tiffany Riehle-Colarusso, Jaime
L. Frías, John Belmont, Marlene Anderka, Tal Geva, Kelly
D. Getz, and Lorenzo D. Botto. 2014. “Laterality Defects in
the National Birth Defects Prevention Study (1998–2007):
Birth Prevalence and Descriptive Epidemiology.” American
Journal of Medical Genetics, Part A 164 (10): 2581–2591.
https://doi.org/10.1002/ajmg.a.36695 .
Liu, Yan, Narendra Pathak, Albrecht Kramer-Zucker, and Iain
A. Drummond. 2007. “Notch Signaling Controls the
Differentiation of Transporting Epithelia and Multiciliated
Cells in the Zebrafsh Pronephros.” Development 134 (6):
1111–1122. https://doi.org/10.1242/dev.02806 .
Loïodice, Isabelle, Annabelle Alves, Gwénaël Rabut, Megan
van Overbeek, Jan Ellenberg, Jean-Baptiste Sibarita, and
Valérie Doye. 2004. “The Entire Nup107–160 Complex,
Including Three New Members, Is Targeted as One Entity to
Kinetochores in Mitosis.” Molecular Biology of the Cell 15
(7): 3333–3344. https://doi.org/10.1091/mbc.e03-12-0878 .
Ma, Ming, and Yun Jin Jiang. 2007. “Jagged2a-Notch Signaling
Mediates Cell Fate Choice in the Zebrafsh Pronephric Duct.”
PLoS Genetics 3 (1): 0133–145. https://doi.org/10.1371/
journal.pgen.0030018 .
Mai, Cara T., Jennifer L. Isenburg, Mark A. Canfeld, Robert E.
Meyer, Adolfo Correa, Clinton J. Alverson, Philip J. Lupo,
et al. 2019. “National Population-Based Estimates for Major
Birth Defects, 2010–2014.” Birth Defects Research 111 (18):
1420–1435. https://doi.org/10.1002/bdr2.1589 .
Maj, Ewa, Lutz Künneke, Elisabeth Loresch, Anita Grund,
Juliane Melchert, Tomas Pieler, Timo Aspelmeier, and
Annette Borchers. 2016. “Controlled Levels of Canonical
Wnt Signaling Are Required for Neural Crest Migration.”
Developmental Biology 417 (1): 77–90. https://doi.org/10.
1016/j.ydbio.2016.06.022 .
Marino, Bradley S., P. H. Lipkin, Jane W. Newburger, Georgina
Peacock, Marsha Gerdes, J. William Gaynor, Kathleen A.
Mussatto, et al. 2012. “Neurodevelopmental Outcomes in
Children with Congenital Heart Disease: Evaluation and
Management a Scientifc Statement from the American Heart
Association.” Circulation 126 (9): 1143–1172. https://doi.
org/10.1161/CIR.0b013e318265ee8a .
Marquez, Jonathan, June Criscione, Rebekah M. Charney,
Maneeshi S. Prasad, Woong Y. Hwang, Emily K. Mis, Martín
I. García-Castro, and Mustafa K. Khokha. 2020. “Disrupted
ER Membrane Protein Complex-Mediated Topogenesis
Drives Congenital Neural Crest Defects.” Journal of Clinical
Investigation 130 (2): 813–826. https://doi.org/10.1172/
JCI129308 .
Mcdermott, Deborah A., Michael C. Bressan, Jie He, Joseph S. Lee,
Salim Aftimos, Martina Brueckner, Fred Gilbert, et al. 2005.
“TBX5 Genetic Testing Validates Strict Clinical Criteria for
Holt-Oram Syndrome.” Pediatric Research 58 (5): 981–986.
https://doi.org/10.1203/01.PDR.0000182593.95441.64 .
McGrath, James, Stefan Somlo, Svetlana Makova, Xin Tian,
and Martina Brueckner. 2003. “Two Populations of Node
Monocilia Initiate Left-Right Asymmetry in the Mouse.”
Cell 114 (1): 61–73. https://doi.org/10.1016/S0092-8674
(03)00511-7 .
Meyer, D., M. Durliat, F. Senan, M. Wolff, M. Andre, J. Hourdry,
and P. Remy. 1997. “Ets-1 and Ets-2 Proto-Oncogenes
Exhibit Differential and Restricted Expression Patterns during Xenopus laevis Oogenesis and Embryogenesis.” Edited by
Derek Stemple. The International Journal of Developmental
Biology 41 (4): 607–620. https://doi.org/10.1371/journal.
pbio.0040010 .
Minegishi, Katsura, Masakazu Hashimoto, Rieko Ajima,
Katsuyoshi Takaoka, Kyosuke Shinohara, Yayoi Ikawa,
Hiromi Nishimura, et al. 2017. “A Wnt5 Activity Asymmetry
and Intercellular Signaling via PCP Proteins Polarize Node
Cells for Left-Right Symmetry Breaking.” Developmental
Cell 40 (5): 439–452.e4. https://doi.org/10.1016/j.devcel.
2017.02.010.
Mussatto, Kathleen A., Raymond G. Hoffmann, George M.
Hoffman, James S. Tweddell, Laurel Bear, Yumei Cao, and
Cheryl Brosig. 2014. “Risk and Prevalence of Developmental