145
Oocytes and Receptors and Channels
TABLE 9.1
Endogenous Ion Channels in the Xenopus Oocyte
Ion Current or
Pharmacology
Associated
Characteristics
Associated Diseases
References
Receptor
Gene Found in of the Channel
Oocytes
Voltage-activated Amiloride
scnn1b, scnn1g Epithelial sodium Liddle syndrome
( Peshkin et al. 2019 ; Yang et al. 2014 ;
sodium-current
sensitive
channel (ENaC)
Parker and Miledi 1987 ) Xenbase
Voltage-activated Ba 2+ sensitive,
Kcnj5
Activation of
Familial hyperaldosteronism
( Parker and Miledi 1988 ; Peshkin et al.
potassium-current hyperpolarization
protein kinase C, type III and type of long QT
2019 ) Xenbase
activated inward
ATP sensitive
syndrome 1 and 13
current
Ba 2+ and
Kcnn2
Small K + channel Long QT syndrome 1
( Parker and Miledi 1988 ; Peshkin et al. 2019 ;
chlof lium
Kcnq1
IsK, minK
Jervell and Lange-Nielsen
Dixit, et al. 2020 ; Sun et al. 2015 ) Xenbase
sensitive
syndrome
______
Kcnk7
twik channel
_______
( Peshkin et al. 2019 ) Xenbase
Voltage-activated Blocked by
Cacna1s
L-type calcium
Periodic paralysis
( Peshkin et al. 2019 ) Xenbase
calcium-current
dihydropyridines, Cacnb1
channel
hypokalemic 1
benzothiazepines
Malignant hyperthermia 5
Thyrotoxic periodic paralysis1
Malignant hyperthermia
Blocked by Cd 2+ , Cacna1h
T type calcium
Childhood absence epilepsy
( Peshkin et al. 2019 ) Xenbase
inactivation by
Cacna1i (Crata) channel
Idiopathic generalized epilepsy
injection of AMPc Cachd1
Blocked by
Cacna2d1,
P type calcium
Familial short QT syndrome
( Peshkin et al. 2019 ; Antzelevitch et al.
bioallethrin
Cacna2d2
channel
Short QT syndrome
2007 ; Pippucci et al. 2013 ) Xenbase
Mechano_______
Trpc4ap
Short transient
_______
( Peshkin et al. 2019 ) Xenbase
sensitive
receptor
current
Blocked by SET2 Trpv2
Activated by
_______
( Peshkin et al. 2019 ) Xenbase
temperature and
chemical,
mechanic stimuli
Blocked by
Trpv4
Activated by
Brachyolmia|Charcot-Marie
( Peshkin et al. 2019 ; Rosenbaum et al.
amiloride,
temperature and tooth disease axonal type 2C
2020 ; McCray et al. 2014 ) Xenbase
gentamicin, Gd 3+ ,
chemical
Metatropic dysplasia
ruthenium red
mechanic stimuli Parastremmatic dwarf sm
Spondyloepiphyseal dysplasia
Maroteaux type
spondylometaphysea
ldysplasia Kozlowski type
Activated by
Trpm4
Melastatin 4,
_______
( Wang, et al. 2018 ; Gao and Liao 2019 ;
intracellular Ca 2+
ATP-binding
Peshkin et al. 2019 )
Xenbase
Nonselective
Current reduced
Gj1a, Gja4,
gj1a(Cxc43),
Oculodentodigital dysplasia
( Oshima 2014 ; Kim et al. 2019 ; Kelly
ion-current
by Ca 2+ and Mg 2+ Gj1b
gja4(Cxc37),
Heart malformations
et al. 2016 ; Macari et al. 2000 ; Peshkin
and negative
gj1b(Cxc32)
Cancers
et al. 2019 ) Xenbase
voltage membrane
Erythorokeratodermia
variabilis et progressive 1
Myocardial infarction
Charcot Marie tooth neuropathy
Chloride ion
Activated by
Tmem16A
Ca 2+ activated
Frontal sinus squamous cell
( Miledi 1982 ; Miledi and Parker 1984 ;
channels
intracellular Ca 2+ , (Ano1)
(CaCC)
carcinoma
Peshkin et al. 2019 ) Xenbase
(Cl - )
blocked by
Frontal sinus cancer
nif umic acid,
DIDS
_______
Clic1
Intracellular
Gallbladder cancer
( Peshkin et al. 2019 ) Xenbase
Clic3
receptor
Pnicilliosis
Gallbladder cancer
(Continued)