109
mis) independently of cell proliferation. It is later required for
NCC survival during neurulation, and cell autonomously
for their initial migration ( Vega-López et al., 2015 ).
Hashimoto, 2009). In these studies, either a mixture of hes4.L
MO + hes4.S MO ( Nagatomo and Hashimoto, 2007 ;
Nichane et al., 2008b ; Maharana and Schlosser, 2018 ),
hes4.L MO alone ( Vega-López et al., 2015 ; Murato et al.,
2007 ), or hes4.S MO alone ( Murato et al., 2007 ) were used.
hes4.L MO but not hes4.S MO affected NCC development
( Murato et al., 2007 ).
GR-DN-hes4.S, GR-DN-hes4.L (Dex NF11) +/− HUA, pH3;
GR-hes4.S-E1A, GR-hes4.L-E1A (Dex NF12.5) : Hes4 acts
as a transcriptional repressor, promoting NCC specif cation
at neural plate/epidermis fates’ expense, independently of
cell proliferation. It is later required for NCC survival
during neurulation and cell-autonomously for their initial
migration ( Vega-López et al., 2015 ).
GR-hes4 DBM (Dex NF11.5–12): same results as GR-hes4
(Dex NF11.5–12) , except that it did not affect soxd and
msx1 ( Nichane et al., 2008b ).
hes5.6
hes5.4
Anterior PPE (neural plate stage); otic vesicle; olfactory,
See Table 7.8 .
See Table 7.8 .
epibranchial, and lateral line placodes (tailbud stage)
( Riddiford and Schlosser, 2016 ).
Anterior PPE (neural plate stage); otic vesicle; olfactory,
epibranchial, and lateral line placodes (tailbud stage)
( Riddiford and Schlosser, 2016 ).
Notch Signaling in Early Embryogenesis