pH. We are continuing to investigate the photophysical properties of resorufin in different solid matrices with a goal of
preventing leaching and optimising pH response.
5. ACKNOWLEDGEMENTS:
The work was funded by grants from the Irish Higher Education Authority, under its Programme for Research in Third
Level Institutions (Cycle 1), a Millennium Research Fund grant (MF9/98/M) from NUI-Galway, and a Research Innovation
Fund Grant (IF/2001/061) from Enterprise Ireland.
6. REFERENCES:
1 M.J.P. Leiner, and O.S. Wolfbeis. Fiber optic pH sensors. In: Fiber optic chemical sensors and biosensors. O.S. Wolfbeis,
editor, pp. 359-384, CRC Press Inc., Boca Raton, Florida, 1991.
2 J.R. Lakowicz, Fluorescence Sensing. In: Principles of fluorescence spectroscopy. p.531-572, Kluwer Acasemic/Plenum
Publishers, New York, 1999.
3 H. Szmacinski and J. R. Lakowicz, Lifetime-Based Sensing. In: Topics in fluorescence spectroscopy: volume 4 Probe design
and chemical sensing, J. R. Lakowicz editor, p.295, Plenum Press, New York, 1994.
4 J.R. Lakowicz, F.N. Castellano, J.D. Dattelbaum, L. Tolosa, G. Rao, and I. Gryczynski. “Low frequency modulation sensors
using nanosecond fluorophores,” Anal. Chem. 70, 5115-5121, 1998.
5 O.S. Wolfbeis, I. Klimant, T. Werner, C. Huber, U. Kosch, C. Krause, G. Neurauter, and A. Durkop. “Set of luminescence
decay time based chemical sensors for clinical applications.” Sens. Actuators B, 51, 17-24, 1998.
6 R. Sanders, A. Draaijer, H.C. Gerritsen, P.M. Houpt, and Y.K. Levine. “Quantitative pH imaging in cells using confocal
fluorescence lifetime imaging microscopy.” Anal. Biochem. 227, 302-302, 1995.
7 R.B. Thompson, J.R. Lakowicz. “Fiber optic pH sensor based on phase fluorescence lifetimes.” Anal. Chem. 65, :853-856,
1993.
8 H. Szmacinski, and J. R. Lakowicz, “Optical measurements of pH using fluorescence lifetimes and phase-modulation
fluorometry, Anal. Chem. 65, 1668-1674, 1993.
9 S. Draxler, M.E. Lippitsch. “Optical pH sensors using fluorescence decay time,” Sens. Actuators B, 11, pp. 421-424, 1993.
10 M. Cajlakovic, A. Lobnik, and T. Werner. “Stability of a new optical pH sensing material based on cross-linked poly(vinyl
alcohol) copolymer”. Anal. Chim. Acta. 455, pp. 207-213, 2002.
11 C. Rottman and D. Avnir. “Getting a library of activities from a single compound: Tunability and very large shifts in acidity
constants induced by sol-gel entrapped micelles,” J. Am. Chem. Soc. 123, pp. 5730-5734, 2001.
12 C. Rottman, G. Grader, Y. De Hazen, S. Melchior, and D. Avnir. “Surfactant-induced modification of dopants reactivity in solgel matrixes.” J. Am. Chem. Soc. 121, pp. 8533-8543, 1999.
13 A.G. Ryder, T.J. Glynn, M. Feely, and A.J.G. Barwise. “Characterization of crude oils using fluorescence lifetime data,”
Spectrochim. Acta (A), 58, pp. 1025-1038, 2002.
14 A.G. Ryder, S. Power, T.J. Glynn, and J.J. Morrison. “Time-domain measurement of fluorescence lifetime variation with pH,”
Proc. SPIE vol. 4259, pp. 102-109, 2001.
15 S. Power, Ph.D. Thesis, National University of Ireland-Galway, 2002.
16 E.F. Gudgin Templeton, and G.A. Kenney-Wallace. “Picosecond laser spectroscopic study of orientational dynamics of probe
molecules in the Me 2 -H 2 O system.” J. Phys. Chem. 90, pp. 2896-2900, 1986.
17 J. O'Brien, I. Wilson, T. Orton, and F. Pognan. “Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment
of mammalian cytotoxicity.” Eur. J. Biochem. 267, pp. 5421-5426, 2000.
preventing leaching and optimising pH response.
5. ACKNOWLEDGEMENTS:
The work was funded by grants from the Irish Higher Education Authority, under its Programme for Research in Third
Level Institutions (Cycle 1), a Millennium Research Fund grant (MF9/98/M) from NUI-Galway, and a Research Innovation
Fund Grant (IF/2001/061) from Enterprise Ireland.
6. REFERENCES:
1 M.J.P. Leiner, and O.S. Wolfbeis. Fiber optic pH sensors. In: Fiber optic chemical sensors and biosensors. O.S. Wolfbeis,
editor, pp. 359-384, CRC Press Inc., Boca Raton, Florida, 1991.
2 J.R. Lakowicz, Fluorescence Sensing. In: Principles of fluorescence spectroscopy. p.531-572, Kluwer Acasemic/Plenum
Publishers, New York, 1999.
3 H. Szmacinski and J. R. Lakowicz, Lifetime-Based Sensing. In: Topics in fluorescence spectroscopy: volume 4 Probe design
and chemical sensing, J. R. Lakowicz editor, p.295, Plenum Press, New York, 1994.
4 J.R. Lakowicz, F.N. Castellano, J.D. Dattelbaum, L. Tolosa, G. Rao, and I. Gryczynski. “Low frequency modulation sensors
using nanosecond fluorophores,” Anal. Chem. 70, 5115-5121, 1998.
5 O.S. Wolfbeis, I. Klimant, T. Werner, C. Huber, U. Kosch, C. Krause, G. Neurauter, and A. Durkop. “Set of luminescence
decay time based chemical sensors for clinical applications.” Sens. Actuators B, 51, 17-24, 1998.
6 R. Sanders, A. Draaijer, H.C. Gerritsen, P.M. Houpt, and Y.K. Levine. “Quantitative pH imaging in cells using confocal
fluorescence lifetime imaging microscopy.” Anal. Biochem. 227, 302-302, 1995.
7 R.B. Thompson, J.R. Lakowicz. “Fiber optic pH sensor based on phase fluorescence lifetimes.” Anal. Chem. 65, :853-856,
1993.
8 H. Szmacinski, and J. R. Lakowicz, “Optical measurements of pH using fluorescence lifetimes and phase-modulation
fluorometry, Anal. Chem. 65, 1668-1674, 1993.
9 S. Draxler, M.E. Lippitsch. “Optical pH sensors using fluorescence decay time,” Sens. Actuators B, 11, pp. 421-424, 1993.
10 M. Cajlakovic, A. Lobnik, and T. Werner. “Stability of a new optical pH sensing material based on cross-linked poly(vinyl
alcohol) copolymer”. Anal. Chim. Acta. 455, pp. 207-213, 2002.
11 C. Rottman and D. Avnir. “Getting a library of activities from a single compound: Tunability and very large shifts in acidity
constants induced by sol-gel entrapped micelles,” J. Am. Chem. Soc. 123, pp. 5730-5734, 2001.
12 C. Rottman, G. Grader, Y. De Hazen, S. Melchior, and D. Avnir. “Surfactant-induced modification of dopants reactivity in solgel matrixes.” J. Am. Chem. Soc. 121, pp. 8533-8543, 1999.
13 A.G. Ryder, T.J. Glynn, M. Feely, and A.J.G. Barwise. “Characterization of crude oils using fluorescence lifetime data,”
Spectrochim. Acta (A), 58, pp. 1025-1038, 2002.
14 A.G. Ryder, S. Power, T.J. Glynn, and J.J. Morrison. “Time-domain measurement of fluorescence lifetime variation with pH,”
Proc. SPIE vol. 4259, pp. 102-109, 2001.
15 S. Power, Ph.D. Thesis, National University of Ireland-Galway, 2002.
16 E.F. Gudgin Templeton, and G.A. Kenney-Wallace. “Picosecond laser spectroscopic study of orientational dynamics of probe
molecules in the Me 2 -H 2 O system.” J. Phys. Chem. 90, pp. 2896-2900, 1986.
17 J. O'Brien, I. Wilson, T. Orton, and F. Pognan. “Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment
of mammalian cytotoxicity.” Eur. J. Biochem. 267, pp. 5421-5426, 2000.
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