1. THE PITUITARY GLAND
23
Fig. 15. Anguilla anguilla. ACTH cells in a surgically interrenalectomized eel.
Compare with control (Fig. 14) and note complete degradation and vacuolation,
with marked nuclear and nucleolar hypertrophy. PbH-PAS, X1100. For details, see
Olivereau and Olivereau ( 1968 ) .
This identscation has been further strengthened by studies in the eel
of the responses of the c cells to a variety of other treatments designed to
alter ACTH-interrenal function; the cells were activated by treatment
with reserpine (Olivereau, 1963c), aldactone ( Olivereau, 1964a),
op’DDD ( Olivereau, 1964b), and inactivated by treatment with cortisol
(Olivereau, 1966c, 1967a) or ACTH (Olivereau, unpublished, quoted in
Olivereau, 1967a). Aldactone also activates these cells in golash
(Olivereau, 1964a), and a heavy infection of the kidney, which partly
destroyed the interrenal, was associated with c cell activation in a Pacific
salmon (Olivereau, 1964a). In Hippocampus, as in the eel, ACTH inactivates the c cells (Boisseau, 1967).