miicus ptws through t h e brtmohial epithelium to the blood vesfiels
where they urc picked up by ttmoebocytes anti accumulate in vacuoles.
Kalk gocs o t i to stlggcst, thtLt thch mucus is then digested in the cell
arid the vanadium tm~umulates on thv vacuolar membrane where an
insolublr cornplcx of vuuadin tri , protein anti sulphate forms coupled
with a cliniigc. of vdrncy from pntavtdeiit to trivalent vanadium. It is
%
Vanadium
Phosphorus
t i t this stagc thtit the signet-ring cell begins to form and the insoluble
comples is deposited in the large vacuole. By a process of ropheocytosis
(Policerd und Bessis, 1958) the granules are reabsorbed into the cytoplasm of the cell where 1 he compartments form and according to Kalk
haemovunadi t i is iiow being synthesized and acid produced resulting in
a solution of liueniovanudin in the compartmwts. Kalk suggests that
the haeniovanadin molecule is made in three strages as follows.
(a) Proteiii grttnules are made by ribosoriies in small vacuoles at
the vesicular mds of Golgi bodies.
(b) Vanadium is transferred from thc compact granules to the
small vacuoles by dispersion of' the grairi~ and solution of their