tlic. (.as(, wit 11 i ~ ~ \ l c ' t ' t ( ' l ) l . i ~ t ( ~
i I I I ~ I O I I I . ? '1'111~ ~l(~s(*ri])tion of' tlw ~norpliologi(:i~l fin(lingh is oI)viol~hl,v ill 111111~~1~stoo(l ;III(I t/lt~~'(> is 111111'11 S(~OI)C lirre
fbr c~xt)c~rir~~c~r~t;~tior, in ;rt, ; l t f t , t ~ 1 ) 1 to sc>pi~t';~t c3 ~ I ' ~ L I I I I I ~ L
t'L'o111 i~if'(~tiolls.
rept~ritt ivc. o l ~~c~opI:~st~i(a l(~sio~~s. kli~rsli1)itrg~r rt (81. ( 1 !)7 1 ) 11oted the
efkcts of' " Nitroso " c~olt~pou~~ds o t ~ thc cn~ytisli Proc.rottbar~~s clnrkii
(Girard, 1852) whicsh, i ~ t
c.oncc~~trations of I00 and 200 p.p.tn., cailsed
cleg(a11erz~tion of' the i ~ t i t ~ l ~ t ~ i ~ l
glt~rld i~tid hyperplasia of the tubular cells
of the h ~ p i ~ t o - \ ) i ~ ~ ~ c ' ~ ' ( \ i ~ s .
One is tttrnp ted to speculate whet her the
hyl)eq~li~sit~ of tllc I t ( ' l ) i ~ t o - l ) : ~ ~ ~ ~ ' r ( a i ~ ~
ttliglit h i ~ v ~
hc~c~ornr neoplastic
(Fig. 2) if' tllc. c*o~tc*c.~~tr-i~tio~~s of' tllct c.ort~l~or~ntl Iiacl 1)c.c:n krigh(.r or the
period of' thcb c>xl)c~rilnc.r~t inc.r.c.ssc~cl. I'~LI~IcY ( I!ftil)) has tvrittc.n ii uscf'ul
criticit1 rrvic~w on llcO[)l2trtii~ i r ~ rrlollrrnc~n, with some 7 3 rr~fi,rc.rtc.c.s.
Farlcy (I!)(i!)) i l l ;I f i ~ ~ ~ t i l ~ t i ~ '
f'e:it of' looki~ig at i~p~)r(~xirr~:it(.ly YO 000
oystcrs ovcr sc.vc11 Y(>:II-S, ~ O L I I I ~
six (li~('ilne(1 oystcr~ i n wt1ic.h thcrc. WiLS
mirroscol~ict~l invirsion hy Q,pical irnrnat ure harn~atoc.ytc~s (f"ig. 9 ) .
These Iiut~n~afoc.ytcs wcw cxtrrmchly active allti rnitotic. figures were
cot111ti011. Th(. aetiologj of this rol~tlitio~~ is unicnowrrl. A ~ i ~ . i i l
artiology
nlll~t t t I w i ~ s I)fb ~011sid('rf~d wII(A~(' the possible [ ) r e ~ ( ~ ~ ~ c . e
of' a c.urc.inogcn
in (.st 11itriue witttlrs, uc.c.ori1pt~11ic.d 1)y biological c.onccsntrtltion within the
ttni~nitl, t1111st L ) c . c~ontc~1nplirt~t1 (('iilititt~ittitl ittlff K U ~ ~ ~ ~ S I I I I < J .
1957).
i I I I ~ I O I I I . ? '1'111~ ~l(~s(*ri])tion of' tlw ~norpliologi(:i~l fin(lingh is oI)viol~hl,v ill 111111~~1~stoo(l ;III(I t/lt~~'(> is 111111'11 S(~OI)C lirre
fbr c~xt)c~rir~~c~r~t;~tior, in ;rt, ; l t f t , t ~ 1 ) 1 to sc>pi~t';~t c3 ~ I ' ~ L I I I I I ~ L
t'L'o111 i~if'(~tiolls.
rept~ritt ivc. o l ~~c~opI:~st~i(a l(~sio~~s. kli~rsli1)itrg~r rt (81. ( 1 !)7 1 ) 11oted the
efkcts of' " Nitroso " c~olt~pou~~ds o t ~ thc cn~ytisli Proc.rottbar~~s clnrkii
(Girard, 1852) whicsh, i ~ t
c.oncc~~trations of I00 and 200 p.p.tn., cailsed
cleg(a11erz~tion of' the i ~ t i t ~ l ~ t ~ i ~ l
glt~rld i~tid hyperplasia of the tubular cells
of the h ~ p i ~ t o - \ ) i ~ ~ ~ c ' ~ ' ( \ i ~ s .
One is tttrnp ted to speculate whet her the
hyl)eq~li~sit~ of tllc I t ( ' l ) i ~ t o - l ) : ~ ~ ~ ~ ' r ( a i ~ ~
ttliglit h i ~ v ~
hc~c~ornr neoplastic
(Fig. 2) if' tllc. c*o~tc*c.~~tr-i~tio~~s of' tllct c.ort~l~or~ntl Iiacl 1)c.c:n krigh(.r or the
period of' thcb c>xl)c~rilnc.r~t inc.r.c.ssc~cl. I'~LI~IcY ( I!ftil)) has tvrittc.n ii uscf'ul
criticit1 rrvic~w on llcO[)l2trtii~ i r ~ rrlollrrnc~n, with some 7 3 rr~fi,rc.rtc.c.s.
Farlcy (I!)(i!)) i l l ;I f i ~ ~ ~ t i l ~ t i ~ '
f'e:it of' looki~ig at i~p~)r(~xirr~:it(.ly YO 000
oystcrs ovcr sc.vc11 Y(>:II-S, ~ O L I I I ~
six (li~('ilne(1 oystcr~ i n wt1ic.h thcrc. WiLS
mirroscol~ict~l invirsion hy Q,pical irnrnat ure harn~atoc.ytc~s (f"ig. 9 ) .
These Iiut~n~afoc.ytcs wcw cxtrrmchly active allti rnitotic. figures were
cot111ti011. Th(. aetiologj of this rol~tlitio~~ is unicnowrrl. A ~ i ~ . i i l
artiology
nlll~t t t I w i ~ s I)fb ~011sid('rf~d wII(A~(' the possible [ ) r e ~ ( ~ ~ ~ c . e
of' a c.urc.inogcn
in (.st 11itriue witttlrs, uc.c.ori1pt~11ic.d 1)y biological c.onccsntrtltion within the
ttni~nitl, t1111st L ) c . c~ontc~1nplirt~t1 (('iilititt~ittitl ittlff K U ~ ~ ~ ~ S I I I I < J .
1957).