268
MAURICE WELSCH
H 8 C
CH S
Amicetin
(XV)
3-hydroxy-8methylcoumarin
OH
4-hydroxy-3(3-methylbutenyl)
benzamide
Novobiocin
(XVI)
HO,
S-CH 2 — CH 2 —o-co—Ρ
y
H s Cj NHI
[-CO^D
OH
N^
I
CH 3
CH 2 —O—CH 3
Celesticetin I
(XVII)
HK
I
CH.
I
CHNH 2 HO'
I
CH 2
CH 2
I
2
CH 2 NH 2
Y
NH
™
1
OH
o^o
CH 2 —CH 2 —0-CH 2 —CHOH—CH 3
Racemomycin Ο
(XVIII)
° In amicetin A: R = CO—CNH 2 —CH 2 OH (α-methyl-D-serine). In amicetin Β:
I
R = H. Bamicetin is the same as amicetin A with a CH 2 less in the furan moiety.
MAURICE WELSCH
H 8 C
CH S
Amicetin
(XV)
3-hydroxy-8methylcoumarin
OH
4-hydroxy-3(3-methylbutenyl)
benzamide
Novobiocin
(XVI)
HO,
S-CH 2 — CH 2 —o-co—Ρ
y
H s Cj NHI
[-CO^D
OH
N^
I
CH 3
CH 2 —O—CH 3
Celesticetin I
(XVII)
HK
I
CH.
I
CHNH 2 HO'
I
CH 2
CH 2
I
2
CH 2 NH 2
Y
NH
™
1
OH
o^o
CH 2 —CH 2 —0-CH 2 —CHOH—CH 3
Racemomycin Ο
(XVIII)
° In amicetin A: R = CO—CNH 2 —CH 2 OH (α-methyl-D-serine). In amicetin Β:
I
R = H. Bamicetin is the same as amicetin A with a CH 2 less in the furan moiety.