GROWTH
INDUCED
BY DAMAGE
I. Introduction
1
II. Nature of the Tissue Response to Damage
2
A. Introduction
2
B. The Response of the Skin Tissues to Damage
2
III. The Specificity of the Growth-Promoting Effects of Damage
.
.
.
13
IV. The Mechanism of Initiation of Damage-Induced Growth
.
.
.
.
18
A. The Biological Basis for the Mechanism of the Initiation of DamageInduced Growth
18
B. The Molecular Basis for the Mechanism of Damage-Induced Growth .
31
V. The Relationship of Damage-Induced Growth to Compensatory Hypertrophy, to Tumor-Induced Growth, and to Embryonic Development
.
36
VI. Summary
40
References
41
I. Introduction
Growth induced by damage is a well known, but still poorly understood
biological problem. Many reviews have appeared on this subject recently,
but they are usually principally concerned with the process of wound
healing itself, rather than wound healing as an experimental model for
the study of growth and its control (Arey, 1936; Allgower, 1956; Russell
and Billingham, 1962; Stoner, 1960; Needham, 1960; Washburn, 1960;
Williamson, 1957). When the emphasis has been to discuss damageinduced growth as a model for growth control, the conclusion has been
reached that it is the local loss of mass (Bullough, 1962, 1964, 1965; Goss,
1964, 1965), resulting in a loss of an inhibitor, that is responsible for the
induction of growth (Bullough, 1962, 1964, 1965; Feingold, 1965).
Bullough (1962) furthermore has actually isolated an epidermal inhibitor. In addition it has been usually concluded that the mechanism of
initiation of growth induced by damage is the same as that which is
responsible for the initiation of growth in compensatory hypertrophy
(Bullough, 1964, 1965).
It is the primary purpose of this paper to review some of the recent
evidence that suggests that the loss of mass with its attendant loss of
1
THOMAS S. ARGYRIS
Department
of Zoology, Syracuse University, Syracuse, New York
INDUCED
BY DAMAGE
I. Introduction
1
II. Nature of the Tissue Response to Damage
2
A. Introduction
2
B. The Response of the Skin Tissues to Damage
2
III. The Specificity of the Growth-Promoting Effects of Damage
.
.
.
13
IV. The Mechanism of Initiation of Damage-Induced Growth
.
.
.
.
18
A. The Biological Basis for the Mechanism of the Initiation of DamageInduced Growth
18
B. The Molecular Basis for the Mechanism of Damage-Induced Growth .
31
V. The Relationship of Damage-Induced Growth to Compensatory Hypertrophy, to Tumor-Induced Growth, and to Embryonic Development
.
36
VI. Summary
40
References
41
I. Introduction
Growth induced by damage is a well known, but still poorly understood
biological problem. Many reviews have appeared on this subject recently,
but they are usually principally concerned with the process of wound
healing itself, rather than wound healing as an experimental model for
the study of growth and its control (Arey, 1936; Allgower, 1956; Russell
and Billingham, 1962; Stoner, 1960; Needham, 1960; Washburn, 1960;
Williamson, 1957). When the emphasis has been to discuss damageinduced growth as a model for growth control, the conclusion has been
reached that it is the local loss of mass (Bullough, 1962, 1964, 1965; Goss,
1964, 1965), resulting in a loss of an inhibitor, that is responsible for the
induction of growth (Bullough, 1962, 1964, 1965; Feingold, 1965).
Bullough (1962) furthermore has actually isolated an epidermal inhibitor. In addition it has been usually concluded that the mechanism of
initiation of growth induced by damage is the same as that which is
responsible for the initiation of growth in compensatory hypertrophy
(Bullough, 1964, 1965).
It is the primary purpose of this paper to review some of the recent
evidence that suggests that the loss of mass with its attendant loss of
1
THOMAS S. ARGYRIS
Department
of Zoology, Syracuse University, Syracuse, New York