GROWTH INDUCED BY DAMAGE
41
specific, requiring damage of the tissue itself for the induction of its
proliferation.
The loss of mass with its attended loss of inhibitor as the stimulus
for damage-induced growth is reviewed. Also the evidence for the release
of stimulating substances or for direct intracellular sublethal damage as
the stimulus mechanism for growth induced by damage is presented. It is
concluded that all hypotheses, to different degrees, have something to
recommend them, but the evidence is not overwhelming for anyone of
them.
Damage-induced growth is compared to growth produced by compensatory hypertrophy and by tumor transplants.
Acknowledgments
The author's work has been supported by grants from the National Science
Foundation, National Institutes of Health, and Ruth Estrin Goldberg Memorial
Foundation for Cancer Research. This review was written while a Special N.I.H.
Fellow at University College, London, 1965-1966.
References
Abercrombie, M. (1957). Symp. Soc. Exptl. Biol. 11, 235.
Abercrombie, M. (1964). Advan. Biol. Skin 5, 95.
Abercrombie, M., and Harkness, R. D. (1951). Proc. Roy. Soc. (London) B138, 544.
Abercrombie, M., and Santler, J. E. (1957). J. Cellular Comp. Physiol. 50, 429.
Allgower, M. (1956). "The Cellular Basis of Wound Repair." Thomas, Springfield,
Illinois.
Arey, L. B. (1936). Physiol. Rev. 16, 327.
Argyris, B. F., and Argyris, T. S. (1959). Exptl. Cell Res. 16, 215.
Argyris, B. F., and Arygris, T. S. (1960). Cancer Res. 20, 325.
Argyris, B. F., and Argyris, T. S. (1961a). Cancer Res. 21, 75.
Argyris, B. F., and Argyris, T. S. (1961b). J. Natl. Cancer Inst. 26, 25.
Argyris, T. S. (1954). Am. J. Anat. 94, 439.
Argyris, T. S. (1956a). AM A. Arch. Pathol. 61, 31.
Argyris, T. S. (1956b). Anat. Record 126, 1.
Argyris, T. S. (1957). Anat. Record 1:27, 697.
Argyris, T. S. (1962). Anat. Record 143, 183.
Argyris, T. S. (1963). Natl. Cancer Inst. Monograph
10, 33.
Argyris, T. S. (1964). Advan. Biol. Skin 5, 231.
Argyris, T. S. (1966a). Advan. Biol. Skin 7, 55.
Argyris, T. S. (1966b). Unpublished observations.
Argyris, T. S., and Argyris, B. F. (1959). Develop. Biol. 1, 269.
Argyris, T. S., and Argyris, B. F. (1962a). Anat. Record 142, 139.
Argyris, T. S., and Argyris, B. F. (1962b). Cancer Res. 22, 73.
Argyris, T. S., and Bell, E. (1959). Anat. Record 134, 153.
Argyris, T. S., and Trimble, M. E. (1964a). Develop. Biol. 9, 230.
41
specific, requiring damage of the tissue itself for the induction of its
proliferation.
The loss of mass with its attended loss of inhibitor as the stimulus
for damage-induced growth is reviewed. Also the evidence for the release
of stimulating substances or for direct intracellular sublethal damage as
the stimulus mechanism for growth induced by damage is presented. It is
concluded that all hypotheses, to different degrees, have something to
recommend them, but the evidence is not overwhelming for anyone of
them.
Damage-induced growth is compared to growth produced by compensatory hypertrophy and by tumor transplants.
Acknowledgments
The author's work has been supported by grants from the National Science
Foundation, National Institutes of Health, and Ruth Estrin Goldberg Memorial
Foundation for Cancer Research. This review was written while a Special N.I.H.
Fellow at University College, London, 1965-1966.
References
Abercrombie, M. (1957). Symp. Soc. Exptl. Biol. 11, 235.
Abercrombie, M. (1964). Advan. Biol. Skin 5, 95.
Abercrombie, M., and Harkness, R. D. (1951). Proc. Roy. Soc. (London) B138, 544.
Abercrombie, M., and Santler, J. E. (1957). J. Cellular Comp. Physiol. 50, 429.
Allgower, M. (1956). "The Cellular Basis of Wound Repair." Thomas, Springfield,
Illinois.
Arey, L. B. (1936). Physiol. Rev. 16, 327.
Argyris, B. F., and Argyris, T. S. (1959). Exptl. Cell Res. 16, 215.
Argyris, B. F., and Arygris, T. S. (1960). Cancer Res. 20, 325.
Argyris, B. F., and Argyris, T. S. (1961a). Cancer Res. 21, 75.
Argyris, B. F., and Argyris, T. S. (1961b). J. Natl. Cancer Inst. 26, 25.
Argyris, T. S. (1954). Am. J. Anat. 94, 439.
Argyris, T. S. (1956a). AM A. Arch. Pathol. 61, 31.
Argyris, T. S. (1956b). Anat. Record 126, 1.
Argyris, T. S. (1957). Anat. Record 1:27, 697.
Argyris, T. S. (1962). Anat. Record 143, 183.
Argyris, T. S. (1963). Natl. Cancer Inst. Monograph
10, 33.
Argyris, T. S. (1964). Advan. Biol. Skin 5, 231.
Argyris, T. S. (1966a). Advan. Biol. Skin 7, 55.
Argyris, T. S. (1966b). Unpublished observations.
Argyris, T. S., and Argyris, B. F. (1959). Develop. Biol. 1, 269.
Argyris, T. S., and Argyris, B. F. (1962a). Anat. Record 142, 139.
Argyris, T. S., and Argyris, B. F. (1962b). Cancer Res. 22, 73.
Argyris, T. S., and Bell, E. (1959). Anat. Record 134, 153.
Argyris, T. S., and Trimble, M. E. (1964a). Develop. Biol. 9, 230.