6
THOMAS S. ARGYRIS
1) and undergo a complete transformation into cords of enlarged basophilic cells. This mass modulation of hair follicle cells occurs irrespective
of whether the follicles are in the growing or resting stage at the time
of injury. In Fig. 1, 5 shows the transformation of resting hair follicles
into cords of cells; 7 and 8 show a growing hair follicle in the process of
transforming into a cord of cells. A single sebaceous cell, all that is left of
the sebaceous gland, is seen in 7. The hair follicle cells above the level of
the sebaceous cell have been transformed into enlarged basophilic cells.
But, the hair follicle cells below the level of the sebaceous cell have not,
as yet, changed into enlarged basophilic cells [Fig. 1 (8)]. Moreover, the
hair follicle cells that undergo keratinization are not transformed into
enlarged basophilic cells. Just when in the process of keratinization a hah
follicle cell loses its ability to change into an enlarged basophilic cell in
response to damage is unknown. This problem deserves attention.
The conversion of hair follicles into hyperplastic cords of enlarged
cells is not limited to surgical wounds. Any kind of damage, be it
mechanical, radiative, or chemical, so long as it is of a critical intensity,
results in the transformation of the hair follicles into hyperplastic cords
of enlarged basophilic cells (Argyris, 1954, 1956a,b; 1957; Argyris and
Bell, 1959).
b. The Response of Hair Follicles beyond 1 mm from the Wound, (i)
Resting hair follicles. Hair follicles distant from the wound, respond
differently to damage depending on whether or not they are in the resting
or growing stage of the hair growth cycle at the time of injury.
Cutting stimulates the growth of resting hair follicles in a variety of
mammals (Fig. 2) (T. S. Argyris and B. F. Argyris, 1959, 1962a; Argyris
and Trimble, 1964a; Borum, 1954; Chase, 1958; Ghadially, 1958; Roney
et al. } 1953). The stimulation of growth of resting hair follicles has also
been observed after X-irradiation or ultraviolet treatment (T. S. Argyris
and B. F. Argyris, 1959; Jolles and Greening, 1958; Turusov, 1966), after
chemically induced damage (Argyris, 1957), and after damage induced
by the intradermal injection of bacteria (Hopkins et al., 1951). Thus,
the stimulation of the growth of resting hair follicles surrounding a wound
is probably a nonspecific response requiring only a critical amount of
damage (Argyris, 1964).
The stimulation of growth of resting hair follicles in wound healing is
different from the growth-promoting effects of damage on the epidermis
and connective tissue, since the growth initiated is normal. This is in
contrast to the induced epidermal and connective tissue proliferation
which is abnormal. Moreover, the resting hair follicle is a complex struc-
THOMAS S. ARGYRIS
1) and undergo a complete transformation into cords of enlarged basophilic cells. This mass modulation of hair follicle cells occurs irrespective
of whether the follicles are in the growing or resting stage at the time
of injury. In Fig. 1, 5 shows the transformation of resting hair follicles
into cords of cells; 7 and 8 show a growing hair follicle in the process of
transforming into a cord of cells. A single sebaceous cell, all that is left of
the sebaceous gland, is seen in 7. The hair follicle cells above the level of
the sebaceous cell have been transformed into enlarged basophilic cells.
But, the hair follicle cells below the level of the sebaceous cell have not,
as yet, changed into enlarged basophilic cells [Fig. 1 (8)]. Moreover, the
hair follicle cells that undergo keratinization are not transformed into
enlarged basophilic cells. Just when in the process of keratinization a hah
follicle cell loses its ability to change into an enlarged basophilic cell in
response to damage is unknown. This problem deserves attention.
The conversion of hair follicles into hyperplastic cords of enlarged
cells is not limited to surgical wounds. Any kind of damage, be it
mechanical, radiative, or chemical, so long as it is of a critical intensity,
results in the transformation of the hair follicles into hyperplastic cords
of enlarged basophilic cells (Argyris, 1954, 1956a,b; 1957; Argyris and
Bell, 1959).
b. The Response of Hair Follicles beyond 1 mm from the Wound, (i)
Resting hair follicles. Hair follicles distant from the wound, respond
differently to damage depending on whether or not they are in the resting
or growing stage of the hair growth cycle at the time of injury.
Cutting stimulates the growth of resting hair follicles in a variety of
mammals (Fig. 2) (T. S. Argyris and B. F. Argyris, 1959, 1962a; Argyris
and Trimble, 1964a; Borum, 1954; Chase, 1958; Ghadially, 1958; Roney
et al. } 1953). The stimulation of growth of resting hair follicles has also
been observed after X-irradiation or ultraviolet treatment (T. S. Argyris
and B. F. Argyris, 1959; Jolles and Greening, 1958; Turusov, 1966), after
chemically induced damage (Argyris, 1957), and after damage induced
by the intradermal injection of bacteria (Hopkins et al., 1951). Thus,
the stimulation of the growth of resting hair follicles surrounding a wound
is probably a nonspecific response requiring only a critical amount of
damage (Argyris, 1964).
The stimulation of growth of resting hair follicles in wound healing is
different from the growth-promoting effects of damage on the epidermis
and connective tissue, since the growth initiated is normal. This is in
contrast to the induced epidermal and connective tissue proliferation
which is abnormal. Moreover, the resting hair follicle is a complex struc-