186
F. Ε.
LEHMANN
References
Begg, R. W. (1958). 'Advances in Cancer Research,' (J. P. Greenstein and A.
Haddow, eds.), 5, pp. 2-55. Academic Press Inc., New York.
Benz, G. (1957). Rev. Suisse Zool. 64, 337.
Benz, G. (1958). Rev. Suisse Zool. 65, 294.
Benz, G. (1959). Oncología 12, 128.
Benz, G., and Lehmann, F. Ε. (1959). Helv.physiol. acta. 17, 380-420.
Biesele, J. J. (1958). 'Mitotic poisons and the cancer problem.' Elsevier Publ.
Company.
Boell, E. J., and Shen, S. C. (1954). Exp. Cell. Res. 7, 147.
Borsook, H., and Keighley, G. L. (1935). Proc. Roy. Soc. (London) Β 118, 488-521.
Campbell, P. N. (1958). 'Advances in Cancer Research,' (J. P. Greenstein and
A. Haddow, eds.), 5, pp. 98-156. Academic Press Inc., New York.
Dettelbach, H. R. (1952). Rev. Suisse Zool. 59, 339.
Deuchar, Ε. M., Weber, R., and Lehmann, F. Ε. (1957). Helv. physiol. acta 15, 212.
Domagk, G. (1956). Dtsch. med. Wschr. 81, Nr. 21.
Druckrey, H., Schmähl, D., and Dischler, W. (1958). Dtsch. med. Wschr. 83,
489-492.
Glinos, A. D. (1958). 'The Chemical Basis of Development,' (W. D. McElroy and
B. Glass, eds.), pp. 813-842. Johns Hopkins Press, Baltimore.
Farber, S., Tock, R., Sears, Ε. M., and Pinkel, D. (1956). 'Advances in Cancer
Research,' (J. P. Greenstein and A. Haddow, eds.) 4, Acad. Press Inc.
Publ., New York.
Finkenstaedt, J. T. (1957). Proc. Soc. exp. Biol. (N.Y.) 95, 302-304.
for tumour growth disappears. Now the situation is brought about in
which a tendency to tumour regression can be induced. Probably single
morphostatic substances have created similar situations in some experiments {Domagk, 1956; Druckrey et ah, 1958; Sträuli, 1959). In these
cases a biological self-degradation is to be assumed. It is not yet clear
how far such processes depend permanently upon the presence of
morphostatic substances. In some cases the role of cathepsins which had
been activated over longer periods seems to be decisive and this needs
further investigation. It seems likely that such cathepsin activators
exert a strong inhibitory action on the development of a hyaloplasm
which is biochemically and structurally very efficient.
All our results seem to demonstrate that systematic inhibition of
regenerating tissues and tumour cells is possible by combinations of
morphostatic substances and this leads to what appears to be an interesting relationship with protein metabolism. This relationship is open to
further biochemical investigation. Protein metabolism seems to take
part in the development of a functionally efficient cytoplasm which is
indispensable for growth and mitosis. Investigations, in this field, by
biochemical research and observations on fine structure can be expected
to contribute greatly to the biology of development and tumours.
F. Ε.
LEHMANN
References
Begg, R. W. (1958). 'Advances in Cancer Research,' (J. P. Greenstein and A.
Haddow, eds.), 5, pp. 2-55. Academic Press Inc., New York.
Benz, G. (1957). Rev. Suisse Zool. 64, 337.
Benz, G. (1958). Rev. Suisse Zool. 65, 294.
Benz, G. (1959). Oncología 12, 128.
Benz, G., and Lehmann, F. Ε. (1959). Helv.physiol. acta. 17, 380-420.
Biesele, J. J. (1958). 'Mitotic poisons and the cancer problem.' Elsevier Publ.
Company.
Boell, E. J., and Shen, S. C. (1954). Exp. Cell. Res. 7, 147.
Borsook, H., and Keighley, G. L. (1935). Proc. Roy. Soc. (London) Β 118, 488-521.
Campbell, P. N. (1958). 'Advances in Cancer Research,' (J. P. Greenstein and
A. Haddow, eds.), 5, pp. 98-156. Academic Press Inc., New York.
Dettelbach, H. R. (1952). Rev. Suisse Zool. 59, 339.
Deuchar, Ε. M., Weber, R., and Lehmann, F. Ε. (1957). Helv. physiol. acta 15, 212.
Domagk, G. (1956). Dtsch. med. Wschr. 81, Nr. 21.
Druckrey, H., Schmähl, D., and Dischler, W. (1958). Dtsch. med. Wschr. 83,
489-492.
Glinos, A. D. (1958). 'The Chemical Basis of Development,' (W. D. McElroy and
B. Glass, eds.), pp. 813-842. Johns Hopkins Press, Baltimore.
Farber, S., Tock, R., Sears, Ε. M., and Pinkel, D. (1956). 'Advances in Cancer
Research,' (J. P. Greenstein and A. Haddow, eds.) 4, Acad. Press Inc.
Publ., New York.
Finkenstaedt, J. T. (1957). Proc. Soc. exp. Biol. (N.Y.) 95, 302-304.
for tumour growth disappears. Now the situation is brought about in
which a tendency to tumour regression can be induced. Probably single
morphostatic substances have created similar situations in some experiments {Domagk, 1956; Druckrey et ah, 1958; Sträuli, 1959). In these
cases a biological self-degradation is to be assumed. It is not yet clear
how far such processes depend permanently upon the presence of
morphostatic substances. In some cases the role of cathepsins which had
been activated over longer periods seems to be decisive and this needs
further investigation. It seems likely that such cathepsin activators
exert a strong inhibitory action on the development of a hyaloplasm
which is biochemically and structurally very efficient.
All our results seem to demonstrate that systematic inhibition of
regenerating tissues and tumour cells is possible by combinations of
morphostatic substances and this leads to what appears to be an interesting relationship with protein metabolism. This relationship is open to
further biochemical investigation. Protein metabolism seems to take
part in the development of a functionally efficient cytoplasm which is
indispensable for growth and mitosis. Investigations, in this field, by
biochemical research and observations on fine structure can be expected
to contribute greatly to the biology of development and tumours.