THE STIMULUS TO HYPERTROPHIC GROWTH
BRIAN POOLE
1
The Rockefeller University, New York, New York
I. Introduction
93
A. The Problem
93
B. Use of Terms
94
C. The Process Controlled
95
II. Theories
96
A. Feedback Inhibition
96
B. Other Theories
100
C. Experimental Analysis
100
III. Experimental Methods and Difficulties
100
A. Measurement of Growth Rate
100
B. Injection of Tissue Extracts
102
C. The Interpretation of Results
102
IV. Hypertrophic Liver Growth
103
A. A Morphological and Biochemical Description
103
B. Factors Influencing the Hypertrophic Response
105
C. Attempted Demonstration of a Humoral Stimulus
107
D. The Importance of the Hepatic Blood Supply
110
E. Summary
Ill
V. Compensatory Renal Hypertrophy
Ill
A. Description of the Process
Ill
B. Factors Modifying the Hypertrophic Response
112
C. Experiments Concerning the Stimulus to Hypertrophy .
.
113
D. Summary
114
VI. Conclusion
114
A. Similarity of Growth Control in Liver and Kidney .
114
B. The Possibility of Humoral Feedback
115
C. The Response Threshold
116
D. Summary
HO
References
I. Introduction
A. The Problem
One of the outstanding unsolved problems of Developmental Biology
is the mechanism of growth control which keeps the relative sizes of organs
'Graduate Fellow of the Rockefeller University.
93