PROBLEMS IN CORNEAL MORPHOGENESIS
93
E
2 0 h
10
0·8
0-6
0·5
0-4
0-3
-o— Dry weight
- · — Wet weight
-A— % Transmission
iM-Htffî
; - »
90
h s o , ,
o
'05
70 |
Φ
c
60 H
50·
10
8
6
5
4
40
Hatching
'9 10 II 12 13 14
21 22 23 24
H 0-8
0-6
-\ 0-5
0-4
S
* σ»
- 4a>
"5
a>
c
o
o
c
σ
a>
15 16 17 18
Age (days)
FIG. 2. Semi-log plots of corneal dry weight, wet weight, and light transmission as
functions of embryonic age. Each point represents the mean of measurements on ten
corneas. The vertical lines represent twice the standard deviation.
in the electrolyte population of the stroma as well as in its failure to
vascularize (Ashton, 1960). The healthy cornea does not contain blood
vessels. Since vascular elements are present in the limbic area early in
the development of most vertebrates, it is clear that the substances and
conditions that prevent their growth into the cornea must exist at these
stages, and that substances and conditions which appear later in development are not necessary to the phenomenon or can, at best, play a
supplementary role. For this reason a detailed study of the composition
and molecular architecture of the immature cornea might aid in unravelling
the physical basis of its failure to vascularize.
D
A.M.4
93
E
2 0 h
10
0·8
0-6
0·5
0-4
0-3
-o— Dry weight
- · — Wet weight
-A— % Transmission
iM-Htffî
; - »
90
h s o , ,
o
'05
70 |
Φ
c
60 H
50·
10
8
6
5
4
40
Hatching
'9 10 II 12 13 14
21 22 23 24
H 0-8
0-6
-\ 0-5
0-4
S
* σ»
- 4a>
"5
a>
c
o
o
c
σ
a>
15 16 17 18
Age (days)
FIG. 2. Semi-log plots of corneal dry weight, wet weight, and light transmission as
functions of embryonic age. Each point represents the mean of measurements on ten
corneas. The vertical lines represent twice the standard deviation.
in the electrolyte population of the stroma as well as in its failure to
vascularize (Ashton, 1960). The healthy cornea does not contain blood
vessels. Since vascular elements are present in the limbic area early in
the development of most vertebrates, it is clear that the substances and
conditions that prevent their growth into the cornea must exist at these
stages, and that substances and conditions which appear later in development are not necessary to the phenomenon or can, at best, play a
supplementary role. For this reason a detailed study of the composition
and molecular architecture of the immature cornea might aid in unravelling
the physical basis of its failure to vascularize.
D
A.M.4