fc^lUUtKM
»Induction
PRIMITIVE
CORNEAL ■
EPITHELIUM
Synthesis
Y
— POSTEPITHELIAL L A Y E R !
^Differentiation
,/—rMiqratigir
■ LIMBICMESENCHYMEMigration
/ STROMAL CELLS
f
I
Differentiation
X
STROMA
STROMAL
FIBROBLASTS
Synthesis
I
COLLAGEN
X Polymerization -^-·
COLLAGEN
FIBRILS
■ GLYCOSAMINOGLYCANS
'*■--*» Aggregation
COLLAGEN
FIBERS
* " " * - Orientation
FIBER
"MATRIX
Y
TENSILE
STRENGTH
Packing-*—
FIBRILLAR
L A T T I C E
Dehydration -«—
EXTRAFIBRILLAR
SPACE DECREASES
- I N VOLUME AND
INCREASES IN
REFRACTIVE INDEX
INTERFERENCE
PATTERN M
INTRINSIC
AND FORM
'BIREFRINGENCE
TRANSPARENCY
METACHROMASIA
SWELLING
PROPERTIES
'Comeal
Pump'
THYROXIN
FIG. 1. Schematic flow-sheet of events in the development of the vertebrate cornea,
by experimental work.
>, Hypothetical relationships.
- ►
CORNEAL
EPITHELIUM
I Synthesis
BASEMENT
MEMBRANE
\
MEME
J.
DESCEMET'S
MEMBRANE
Synthesis
POSTERIOR
EPITHELIUM
>-, Influences that are clearlv indicated
to
>
»
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O
O
d
o
»