CO
CD
T A B L E I
Properties o f tissue acid mucopolysaccharides
Action of
hyaluronidase
Cone, of
ethanol
to ppt.
C a + + salt
Principal
tissue source
Some examples of mucopolysaccharide
production in Tissue Culture by:
Mucopolysaccharide
Composition
Testicular
Pneumococcal
Rotation
Cone, of
ethanol
to ppt.
C a + + salt
Principal
tissue source
Cells
Explants
Chondroitin
jV-acetylgalactosamine
Glucuronic acid
(1)
(1)
+
+
- 20° to - 37°
~
Cornea
-
-
Hyaluronic
acid ( H A )
JV-acetylglucosamine
Glucuronic acid
(1)
(1)
+
- 5 1 ° to - 9 7 °
3 0 %
Vitreous humour.
Synovial fluid.
Umbilical cord.
Rheumatic
nodules. Rooster
comb. Embryonic
skin
Rat dermal fibroblasts. H u m a n
synovial cells.
Human tendon
cells. Osteogenic
fibroblasts
Pig embryonic skin.
H u m a n bone. H u m a n
tendon. H u m a n aorta.
Human pericardium.
H u m a n synovial
membrane. Walker
tumour 256
Chondroitin
sulphate A
(CSA-A)
^-acetylgalactosamine
Glucuronic acid
Sulphate
(1)
(1)
(1)
+
- 28° to - 32°
3 0 - 4 0 %
Cartilage. Bone.
Aorta. Cornea.
Ligamentum
nuchae. Nasal
septa
Fibroblasts
Chondroitin
sulphate B
(CSA-B)
.^-acetylgalactosamine
Iduronic acid
Sulphate
(1)
(1)
(1)
- 55° to - 63°
1 8 - 2 5 %
Aorta. Heart valves.
Ligamentum
nuchae. Skin.
Tendon
Fibroblasts
Pig embryonic skin
Chondroitin
sulphate C (CSA-C)
JV-acetylgalactosamine
Glucuronic acid
Sulphate
(1)
(1)
(1)
+
- 12° to - 2 2 °
4 0 - 5 0 %
Cartilage. Nucleus
pulposus. Tendon.
Heart valve
Fibroblasts
Pig embryonic skin.
H u m a n skin
Heparitin sulphate
Glucosamine
Glucuronic acid
Sulphate
Acetyl
(1)
(1)
(1)
(0-5)
+ 39° to + 6 9 °
Aorta
Amyloid
—
Keratosulphate
JV-acetylglucosamine
Galactose
Sulphate
(1)
(1)
(1)
+
+
+ 4-5°
5 0 %
Cornea
Bone
Cartilage
Nucleus pulposus
J. T. D I N G L E A N D M. W E B B