CARBON-CARBON BOND FORMING REACTIONS
71
I.B.1-4 Lawrence, N.J. and Muhammad, F., TL, 35, 5903.
Br"
Ph' Ph
R
1
TMP, NBS
CHC1 3 , rt*
R
R
1
56-94%
E:Z = 1:1-4
I.B.1-5 Lawrence, J. et al., TL, 35, 6733
1. BuLi
RCH 2 P(0)Ph 2
" ,
»
R - ^ -
R
2. R
! CHO
K
62-99%
I.B.1-6 Mikolajczyk, M. and Mikina, M., JOC, 59, 6760; Amat-Guerri,
F. et al., TL, 35, 5907; Bonadier, F. et al., TL, 35, 3385.
.0
(RO) 2 P
O
(RO) 2 P*
O
k ^ O DCH-18-CI--6
//
r--KJ
K 2 CO 3 _ ( R O ^ p ^ r ^
//
Ph-H
reflux, 12h
O
25-90%
LB.1-7 Burton, DJ. et al., JOC, 59, 7085; see also: Zhao, K. et al.,
TL, 35, 2827.
O
M F
(EtO) 2 P.
1. CICOC0 2 Me
M e 0 r
F
X 0 2 E t
THF
M e ü 2 C F
2. AlkMgX
*~
/ \
-78°C->rt
A , k
C0 2 Et
48-55%
E:Z = 24-100:1
71
I.B.1-4 Lawrence, N.J. and Muhammad, F., TL, 35, 5903.
Br"
Ph' Ph
R
1
TMP, NBS
CHC1 3 , rt*
R
R
1
56-94%
E:Z = 1:1-4
I.B.1-5 Lawrence, J. et al., TL, 35, 6733
1. BuLi
RCH 2 P(0)Ph 2
" ,
»
R - ^ -
R
2. R
! CHO
K
62-99%
I.B.1-6 Mikolajczyk, M. and Mikina, M., JOC, 59, 6760; Amat-Guerri,
F. et al., TL, 35, 5907; Bonadier, F. et al., TL, 35, 3385.
.0
(RO) 2 P
O
(RO) 2 P*
O
k ^ O DCH-18-CI--6
//
r--KJ
K 2 CO 3 _ ( R O ^ p ^ r ^
//
Ph-H
reflux, 12h
O
25-90%
LB.1-7 Burton, DJ. et al., JOC, 59, 7085; see also: Zhao, K. et al.,
TL, 35, 2827.
O
M F
(EtO) 2 P.
1. CICOC0 2 Me
M e 0 r
F
X 0 2 E t
THF
M e ü 2 C F
2. AlkMgX
*~
/ \
-78°C->rt
A , k
C0 2 Et
48-55%
E:Z = 24-100:1