CARBON-CARBON BOND FORMING REACTIONS
57
I.A.7.b.2-2 Yamamoto, Y. et al., CC, 2003.
A Chemical Scale for Electron-Transfer Ability of
Methylcopper Reagents
I.A.7.b.2-3 Overman, L.E. et al., JOC, 59, 1946.
RMgX, Cui
M e 0 2 C v ^ ^ . C 0 2 M e
► Me0 2 C. > s ^ XCsMe
^ ^ \ /
TMSCI, THF
2 ^ ^ ^ ^
2
■78°C to rt
77-85%
I.A.7.b.2-4 Kanai, M. and Tomioka, K., TL 35, 895; Tanaka, K. et al.,
SL, 351; van Koten, G. et al., TL, 35, 6135.
CuCN, LiBr, Et 2 0
// + RLi
1=^
►
9r
CO'Bu
PPh 2
90-99%, 68-95% ee
chiral alkoxydimethylcuprate & arenethiolato copper(I) catalysts
used for similar transformations
57
I.A.7.b.2-2 Yamamoto, Y. et al., CC, 2003.
A Chemical Scale for Electron-Transfer Ability of
Methylcopper Reagents
I.A.7.b.2-3 Overman, L.E. et al., JOC, 59, 1946.
RMgX, Cui
M e 0 2 C v ^ ^ . C 0 2 M e
► Me0 2 C. > s ^ XCsMe
^ ^ \ /
TMSCI, THF
2 ^ ^ ^ ^
2
■78°C to rt
77-85%
I.A.7.b.2-4 Kanai, M. and Tomioka, K., TL 35, 895; Tanaka, K. et al.,
SL, 351; van Koten, G. et al., TL, 35, 6135.
CuCN, LiBr, Et 2 0
// + RLi
1=^
►
9r
CO'Bu
PPh 2
90-99%, 68-95% ee
chiral alkoxydimethylcuprate & arenethiolato copper(I) catalysts
used for similar transformations