378
ORGANIC SYNTHESIS—1995
VLA.13-15 Kyziol, J.B. et al., OPP, 26, 337.
R
R
I
1; EtMgBr
I
R ,/%
2: BuON0 2
R /%o 2
40-70 %
VI.A.13-16 Maffre, D. et al., JCR(S), 30; Bulman Page, P.C. et al., TL, 35,
2427; Cuadro, A.M. and Alvarez-Builla, J., T, 50, 10037.
O
O
Boc
R\H
l:BuLi,THF,-78°C
R'^N
I
R ./
K \^
K
2: BocN=NBoc, THF
R·^ >^
V N
-78°C
I
|
R
Boc
33-75 %
VI.A.13-17 Rakitin, O.A. et al., OPP, 26, 331.
P Ss^>S0 2 PI.
^H 2 SQ 4> CHC1 3> A
"S^^
|
z
2:Ph-Me,A
I
Ph
™ 80%
VI.A.13-18 Hutchins, R.O. et al., JOC, 59, 4007.
R3
Pd(PPh 3 ) 4 ,THF,A > Rl/ ^^k N ^P03Et 2
Boc
|
|
J.
R
2
Boc
^
N -
Et 2 0 3 P
Na
19-98 %
ORGANIC SYNTHESIS—1995
VLA.13-15 Kyziol, J.B. et al., OPP, 26, 337.
R
R
I
1; EtMgBr
I
R ,/%
2: BuON0 2
R /%o 2
40-70 %
VI.A.13-16 Maffre, D. et al., JCR(S), 30; Bulman Page, P.C. et al., TL, 35,
2427; Cuadro, A.M. and Alvarez-Builla, J., T, 50, 10037.
O
O
Boc
R\H
l:BuLi,THF,-78°C
R'^N
I
R ./
K \^
K
2: BocN=NBoc, THF
R·^ >^
V N
-78°C
I
|
R
Boc
33-75 %
VI.A.13-17 Rakitin, O.A. et al., OPP, 26, 331.
P Ss^>S0 2 PI.
^H 2 SQ 4> CHC1 3> A
"S^^
|
z
2:Ph-Me,A
I
Ph
™ 80%
VI.A.13-18 Hutchins, R.O. et al., JOC, 59, 4007.
R3
Pd(PPh 3 ) 4 ,THF,A > Rl/ ^^k N ^P03Et 2
Boc
|
|
J.
R
2
Boc
^
N -
Et 2 0 3 P
Na
19-98 %