PROTECTING GROUPS
V.A. Hvdroxvl Protecting Groups
V.A-l Lee, S.G. et al., JCS(Pl), 2621 and TL, 35, 9737.
OMe
NHCbz
Dowex 50W-8X
aq MeOH
*· HO
HO
OMe
NHCbz
O
Regioselective Hydrolysis
95%
V.A-2 Niculescu-Duvaz, I. and Springer, C.J., JCR(S), 242; Hodgetts, K.J.
and Wallace, T.W., SC, 24, 1151.
O
OH
EWGF ^ ^ O A d , pyr
O
A
O
Ad
F
42-94 %
V
EWGTFA
F
54-95 %
315
V.A. Hvdroxvl Protecting Groups
V.A-l Lee, S.G. et al., JCS(Pl), 2621 and TL, 35, 9737.
OMe
NHCbz
Dowex 50W-8X
aq MeOH
*· HO
HO
OMe
NHCbz
O
Regioselective Hydrolysis
95%
V.A-2 Niculescu-Duvaz, I. and Springer, C.J., JCR(S), 242; Hodgetts, K.J.
and Wallace, T.W., SC, 24, 1151.
O
OH
EWGF ^ ^ O A d , pyr
O
A
O
Ad
F
42-94 %
V
EWGTFA
F
54-95 %
315