CARBON-CARBON BOND FORMING REACTIONS
5
I.A.2. Alkvlations of Nitriles. Acids and Acid Derivatives
I.A.2-1 Melikyan, G.G. et al., JOU, 30, 222.
O
+
A„
+
AA
Mn(OAc) 3
JOAc
HO
OAc
I.A.2-2 Jenkins, P.R. et al., TL, 35, 5501; see also: Mclntosh, J.M.,
Ager, DJ. et al., T, 50, 1967 and 1975; see also: Costa, P.R.R. et al., TA,
5, 1219.
C0 2 -(+)-Men υ LDA , _ 25 °C \—>
■■"CO,H
2)
.Cl
\>
C
°2-(+)Men
r'V-iCOaH
+
96%, 4.9:1
other chiral auxiliaries used similarly
~V*C0 2 -(+
C \-iC0 2 H
)-Men
5
I.A.2. Alkvlations of Nitriles. Acids and Acid Derivatives
I.A.2-1 Melikyan, G.G. et al., JOU, 30, 222.
O
+
A„
+
AA
Mn(OAc) 3
JOAc
HO
OAc
I.A.2-2 Jenkins, P.R. et al., TL, 35, 5501; see also: Mclntosh, J.M.,
Ager, DJ. et al., T, 50, 1967 and 1975; see also: Costa, P.R.R. et al., TA,
5, 1219.
C0 2 -(+)-Men υ LDA , _ 25 °C \—>
■■"CO,H
2)
.Cl
\>
C
°2-(+)Men
r'V-iCOaH
+
96%, 4.9:1
other chiral auxiliaries used similarly
~V*C0 2 -(+
C \-iC0 2 H
)-Men