CARBON-CARBON BOND FORMING REACTIONS
111
I.E.1-29 Haynes, R.K., King, G.R. and Vonwiller, S.C., JOC, 59,
4743.
Cu(OTf) 2
O
HO
MeCN, -20°C
42%
I.E.1-30 Posner, G.H. et al., TL, 35, 7541; Mikami, K. et al., JACS,
116, 2812; Ishihara, K. and Yamamoto, H., JACS, 116, 1561; Kobayashi,
S. et al., T, 50, 11623.
L-l
(R)-(+)-BINOL-TiCl 2 ('PrO) 2
O
OR
Ph-Me, -30°C, 12-24h
OR
O r
CO,Me
86-90%
e.e. = 95-98%
I.E.1-31 Yamamoto, I. and Narasaka, K., BCJ, 67, 3327; Yamamoto,
H. T, 50, 8983; Kobayashi, S. et al., JOC, 59, 3758; Oh, T. and Reilly,
M., TL, 35, 7209; Itsuno, S. et al., TA, 5, 523; Cativiela, C. et al., JOC,
59, 7774.
OAc
, Β ^
O
O
O
r\
T'Y
0
° o
Ph
Ph
£
OH
AcÔ
OH
p h
82%
e.e. = 94%